Abstract
Initially during myocardial hypoxia or ischemia, development of contractile force declines. Ultimately the myocardial cell fails completely to develop contractile force and is usually fully relaxed at this stage [1]. With continued impairment of adenosine triphosphate (ATP) synthesis, the ischemic myocardial cell begins to develop an increase in resting tension. This increase in resting tension could be due to a rise in cytosolic free Ca2+ ion concentration, [Ca2+]i, or a fall in ATP concentration, which could produce rigor due to failure of actin-myosin cross-bridge dissociation [2].
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© 1987 Martinus Nijhoff Publishing
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Barry, W.H. (1987). Is Ischemic Contracture Preceded by a Rise in Free Calcium?. In: Grossman, W., Lorell, B.H. (eds) Diastolic Relaxation of the Heart. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6832-2_5
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DOI: https://doi.org/10.1007/978-1-4615-6832-2_5
Publisher Name: Springer, Boston, MA
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