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Phenotypic Changes in Cell Culture

  • Chapter
Genomic Adaptability in Somatic Cell Specialization

Part of the book series: Developmental Biology ((DEBO,volume 6))

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Abstract

The history and evolution of cell populations in vitro stem initially from characteristics of the tissues or organs used for explantation. As developmental products, each of these carries a spectrum of identifying markers: distinctive patterns of enzyme activities or unique metabolic products, diagnostic cytoarchitecture or elements of fine structure, and other specificities recognizable microscopically or biochemically. Phenotypic changes in early cultures of animal cells thus commonly derive from forward or retrograde shifts in state of differentiation, rather than from alterations at the genetic level.

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Authors and Affiliations

  1. Department of Zoology, University of California-Berkeley, Berkeley, California, 94720, USA

    Morgan Harris

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© 1989 Plenum Press, New York

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Harris, M. (1989). Phenotypic Changes in Cell Culture. In: Genomic Adaptability in Somatic Cell Specialization. Developmental Biology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6820-9_5

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  • DOI: https://doi.org/10.1007/978-1-4615-6820-9_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6822-3

  • Online ISBN: 978-1-4615-6820-9

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