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Genomic Imprinting in the Mouse

  • Chapter
Genomic Adaptability in Somatic Cell Specialization

Part of the book series: Developmental Biology ((DEBO,volume 6))

Abstract

In retrospect, perhaps it is not surprising that in mammals the two parental genomes have different influences on the developing embryo. However, it is only recently that the functional nonequivalence of the maternal and paternal genomes has been established conclusively and so has commanded a considerable amount of interest. This chapter reviews experiments that have demonstrated the complementary roles of the two parental genomes in the mouse, thus establishing the existence of genomic imprinting in murine development. Also, we indicate some of the approaches being employed to elucidate the molecular basis of this phenomenon.

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Authors and Affiliations

  1. Department of Molecular Embryology, Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, CB2 4AT, England

    S. K. Howlett, W. Reik, S. C. Barton, M. L. Norris & M. A. H. Surani

Authors
  1. S. K. Howlett
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  2. W. Reik
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  3. S. C. Barton
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  4. M. L. Norris
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  5. M. A. H. Surani
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© 1989 Plenum Press, New York

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Howlett, S.K., Reik, W., Barton, S.C., Norris, M.L., Surani, M.A.H. (1989). Genomic Imprinting in the Mouse. In: Genomic Adaptability in Somatic Cell Specialization. Developmental Biology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6820-9_4

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  • DOI: https://doi.org/10.1007/978-1-4615-6820-9_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6822-3

  • Online ISBN: 978-1-4615-6820-9

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