Abstract
The techniques of molecular biology have been brought to bear on the mysteries of early development in the hope that new approaches would lead to a clearer understanding of how overt pattern is formed from its invisible antecedents. The molecules involved in pattern formation have been made visible by molecular probes and have been manipulated by mutation, genetic engineering, and injection. In the study of Drosophila development, the key discoveries made using molecular techniques have been heavily dependent on the genetic analyses that provided the molecular biologists with working material. In many ways, genetic studies continue to lead the way, guiding molecular biologists to the genes that matter most.
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In spite of ourselves the question is forced upon us whether we must not assume the existence, even in the unsegmented egg, of a quite definite and orderly grouping and distribution of the protoplasmic particles and molecules. C. Rabl (1879)
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Scott, M.P. (1988). The Molecular Biology of Pattern Formation in the Early Embryonic Development of Drosophila . In: Browder, L.W. (eds) The Molecular Biology of Cell Determination and Cell Differentiation. Developmental Biology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6817-9_5
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