Skip to main content
SpringerLink
Log in

Drugs and the Kidney

  • Chapter
Contemporary Nephrology

  • 60 Accesses

Abstract

In the past 2 years, there has been continued emphasis in the literature on drug therapy in the patient with kidney disease. Vesell provided a concise summary of the influence of renal disease on drug response.1 He emphasized the multiple host factors affecting drug disposition besides renal dysfunction which preclude a simplistic view of the problem for the clinician.2 Paxton summarized the highlights of a conference on therapeutic drug monitoring at the First World Congress in Clinical Pharmacology and Therapeutics.3 The basic pharmacokinetic principles on which practical clinical use of drugs is based are well covered in recent books and papers.4–7 Tables providing updated specific dosage recommendations are also available.8’9 Fabre et al. have provided a useful practical framework based on kinetic principles on which to select a drug of choice for the renal failure patient among any given class of drugs such as β-adrenoreceptor blocking agents or antibiotics.10

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Vesell, E., 1981, The influence of host factors on drug response. VII. Renal diseases, Rat Drug Ther. 15:1.

    Google Scholar 

  2. Vesell, E., 1982, On the significance of host factors that affect drug disposition, Clin. Pharmacol. Ther. 31:1.

    Article  PubMed  CAS  Google Scholar 

  3. Paxton, J. W., 1981, Therapeutic drug monitoring and clinical pharmacokinetics, Austr. N. Z. J. Med. 11:558.

    Article  CAS  Google Scholar 

  4. Anderson, R. and Schrier, R. (eds), 1981, Clinical Use of Drugs in Patients with Kidney and Liver Disease, W. B. Saunders, Philadelphia, p. 1.

    Google Scholar 

  5. Reidenberg, M. M. and Drayer, D. E., 1980, Drug therapy in renal failure, Ann. Rev. Pharmacol. Toxicol. 20:45.

    Article  CAS  Google Scholar 

  6. Muther, R. S. and Bennett, W. M., 1981, Drug metabolism in renal failure, in: Chronic Renal Failure (B. Brenner and, J. Stein, eds.), Churchill-Livingstone, New York, p. 287.

    Google Scholar 

  7. Brater, D. C., 1980, The pharmacological role of the kidney, Drugs 19:31.

    Article  PubMed  CAS  Google Scholar 

  8. Gambertoglio, J. G., 1981, Drug reference tables, in: Clinical Use of Drugs in Patients with Kidney and Liver Disease (R. Anderson and R. Schrier, eds.), W.B. Saunders, Philadelphia, p. 311.

    Google Scholar 

  9. Anderson, R. J., Bennett, W. M., Gambertoglio, J. G., and Schrier, R. W., 1981, Fate of drugs in renal failure, in: The Kidney (B. Brenner and F. Rector, eds.), W.B. Saunders, Philadelphia, p. 2659.

    Google Scholar 

  10. Fabre, J., Fox, H. M., Dayer, P., and Balant, L., 1980, Differences in kinetic properties of drugs: Implications as to the selection of a particular drug for use in patients with renal failure, Clin. Pharmacokinet. 5:441.

    Article  PubMed  CAS  Google Scholar 

  11. Wizemann, V., Birk, H. W., and Schutter, L. E., 1981, Impaired intestinal digoxin absorption in experimental chronic uremia, Nephron 28:297.

    Article  PubMed  CAS  Google Scholar 

  12. Gambertoglio, J. G., Amend, W., and Benet, L. Z., 1980, Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: A review, J. Pharmacokinet. Biopharm. 8:1.

    Article  PubMed  CAS  Google Scholar 

  13. Gambertoglio, J., Vincenti, F., Feduska, N., Birnbaum, J., Salvatierra, O., and Amend, W., 1980, Prednisolone disposition in cushingoid and noncushingoid kidney transplant patients, J. Clin. Endocrinol. Metab. 51:561.

    Article  PubMed  CAS  Google Scholar 

  14. Spencer, H., Kramer, L., Norris, C., and Wiatrowski, E., 1980, Effect of aluminum hydroxide on fluoride metabolism, Clin. Pharmacol. Ther. 28:529.

    Article  PubMed  CAS  Google Scholar 

  15. Beermann, B. and Growchinsky-Grind, M., 1980, Clinical pharmacokinetics of diuretics, Clin. Pharmacokinet. 5:221.

    Article  PubMed  CAS  Google Scholar 

  16. Lanao, J. M., Dominguez-Gil, A., Macias, J. G., Diez, J. L., and Nieto, M. J., 1980, The influence of ascites on the pharmacokinetics of amikacin, Int. J. Clin. Pharmacol. Ther. Toxicol. 18:57.

    PubMed  CAS  Google Scholar 

  17. Richey, G. D. and Schleupner, C. J., 1981, Peritoneal fluid concentrations of gentamicin in patients with spontaneous bacterial peritonitis, Antimicrob. Agents Chemother. 19:312.

    PubMed  CAS  Google Scholar 

  18. Korsager, S., 1980, Administration of gentamicin to obese patients, Int. J. Clin. Pharmacol. Ther. Toxicol. 18:549.

    PubMed  CAS  Google Scholar 

  19. Sketris, I., Lesar, T., Zaske, D. E., and Cipolle, R. J., 1981, Effect of obesity on gentamicin pharmacokinetics, J. Clin. Pharmacol. 21:288.

    PubMed  CAS  Google Scholar 

  20. Piafsky, K. M., 1980, Disease-induced changes in the plasma binding of basic drugs, Clin. Pharmacokinet. 5:246.

    Article  PubMed  CAS  Google Scholar 

  21. Lima, J. J., Boudoulas, H., and Blanford, M., 1981, Concentration-dependence of disopyramide binding to plasma protein and its influence on kinetics and dynamics, J. Pharmacol. Exp. Ther. 219:741.

    PubMed  CAS  Google Scholar 

  22. Pike, E., Skuterud, B., Kiefulf, P., Fremstad, D., Abdel-Sayed, S. M., and Lunde, P. K. M., 1981, Binding and displacement of basic, acidic and neutral drugs in normal and orosomucoid-deficient plasma, Clin. Pharmacokinet. 6:367.

    Article  PubMed  CAS  Google Scholar 

  23. Brown, J. E., Kitchell, B. B., Bjornsson, T. D., and Shand, D. B., 1981, The artifactual nature of heparin-induced drug protein-binding alterations, Clin. Pharmacol. Ther. 30:636.

    Article  PubMed  CAS  Google Scholar 

  24. Depner, T. A. and Gulyassy, P. F., 1980, Plasma protein binding in uremia: Extraction and characterization of an inhibitor, Kidney Int. 18:86.

    Article  PubMed  CAS  Google Scholar 

  25. Depner, T. A., 1981, Suppression of tubular anion transport by an inhibitor of serum protein binding in uremia, Kidney Int. 20:511.

    Article  PubMed  CAS  Google Scholar 

  26. Kinniburgh, D. W. and Boyd, N. D., 1981, Phenytoin binding to partially purified albumin in renal disease, Clin. Pharmacol. Ther. 29:203.

    Article  PubMed  CAS  Google Scholar 

  27. Erill, S., Calvo, R., and Carlos, R., 1980, Plasma protein carbamylation and decreased acidic drug protein binding in uremia, Clin. Pharmacol. Ther. 27:612.

    Article  PubMed  CAS  Google Scholar 

  28. Kessler, K. M. and Perez, G. O., 1981, Decreased quinidine plasma protein binding during hemodialysis, Clin. Pharmacol. Ther. 30:121.

    Article  PubMed  CAS  Google Scholar 

  29. Wassner, S. J., Malekzadeh, M. H., Pennisi, A. J., Ettenger, R. B., Vittenbogaart, C. H., and Fine, R. N., Allograft survival in patients receiving anticonvulsant medications, 1977, Clin. Nephrol. 8:293.

    PubMed  CAS  Google Scholar 

  30. Gambertoglio, J., Saltiel, M., Nishikawa, R., Lizak, P., and Amend, W., 1982, Effects of anticonvulsants on prednisolone metabolism in renal transplant recipients, Clin. Res. 30:78A.

    Google Scholar 

  31. Verbeeck, R. K., Branch, R. A., and Wilkinson, G. R., 1981, Drug metabolites in renal failure: Pharmacokinetic and clinical implications, Clin. Pharmacokinet. 6:329.

    Article  PubMed  CAS  Google Scholar 

  32. Munn, S., Bailey, R. R., Begg, E., Ebert, R., and Ferry, D. G., 1980, Plasma and urine concentrations of acetutolol and its acetyl metabolite in patients with renal function impairment, N. Z. Med. J. 91:289.

    PubMed  CAS  Google Scholar 

  33. Jordo, L., Altman, P. O., Aurell, M., Johansson, L., Johnsson, G., and Regardh, C. G., 1980, Pharmacokinetic and pharmacodynamic properties of metoprolol in patients with impaired renal function, Clin. Pharmacokinet. 5:169.

    Article  PubMed  CAS  Google Scholar 

  34. Gibson, T. P., Giacomini, K. M., Briggs, W. A., Whitman, W., and Levy, G., 1980, Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient, Clin. Pharmacol. Ther. 27:665.

    Article  PubMed  CAS  Google Scholar 

  35. Verbeeck, R. K., Tjandramaga, T. B., and DeSchepper, P. J., 1981, Impaired elimination of lorazepam following subchronic administration in two patients with renal failure, Br. J. Clin. Pharmacol. 12:749.

    PubMed  CAS  Google Scholar 

  36. Stone, W. J., Warnock, L. G., and McKinney, T. D., 1980, Spurious hyperbilirubinemia in uremic patients on high dose propranolol therapy, Clin. Pharmacol. Ther. 27:288.

    Google Scholar 

  37. Burgess, E. D., Friel, P. N., Blair, A. D., and Raisys, V. A., 1981, Serum phenytoin concentrations in uremia, Ann. Intern. Med. 94:59.

    PubMed  CAS  Google Scholar 

  38. Davis, B. B., Mattammal, M. B., and Zenser, T. V., 1981, Renal metabolism of drugs and xenobiotics, Nephron 27:187.

    Article  PubMed  CAS  Google Scholar 

  39. Park, B. K. and Breckenridge, A. M., 1981, Clinical implications of enzyme induction and enzyme inhibition, Clin. Pharmacokinet. 6:1.

    Article  PubMed  CAS  Google Scholar 

  40. Abernathy, D. R., Greenblatt, D. J., and Divoll, M., 1982, Differential effects of Cimetidine on drug oxidation versus conjugation: Potential mode of therapy for acetaminophen hepatotoxicity, Clin. Pharmacol. Ther. 31:198.

    Article  Google Scholar 

  41. Pazmino, P. A., Sladek, S. L., and Weinshilboum, R. M., 1980, Thiol-5-methylation in uremia: Erythrocyte enzyme activities and plasma inhibitors, Clin. Pharmacol. Ther. 28:356.

    Article  PubMed  CAS  Google Scholar 

  42. Gibson, T. P. and Quintanilla, A., 1980, The renal clearance of digoxin is dependent upon the serum digoxin concentration, J. Pharmacol. Exp. Ther. 215:681.

    PubMed  CAS  Google Scholar 

  43. Gibson, T. P. and Quintanilla, A., 1981, Effect of volume expansion and furosemide diuresis on the renal clearance of digoxin, J. Pharmacol. Exp. Ther. 219:54.

    PubMed  CAS  Google Scholar 

  44. Risler, T., Somberg, J. C., and Smith, T. W., 1981, Renal elimination of digoxin: Studies with tritiated digoxin and radioimmunoassay, J. Pharmacol. Exp. Ther. 218:368.

    PubMed  CAS  Google Scholar 

  45. Sand, T. E. and, Jacobsen, S., 1981, Effect of urine pH and flow on renal clearance of methotrexate, Eur. J. Clin. Pharmacol. 19:453.

    Article  PubMed  CAS  Google Scholar 

  46. Vlasses, P. H., Holbrook, A. M., Schrogie, J. J., Rogers, J. D., Ferguson, R. K., and Abrams, W. B., 1981, Effect of orally administered probenecid on the pharmacokinetics of cefoxitin, Antimicrob. Agents Chemother. 17:847.

    Google Scholar 

  47. Luthy, R., Blaser, J., Bonetti, A., Simmen, H., Wise, R., and Siegenthaler, W., 1981, Comparative multiple-dose pharmacokinetics of cefotaxime, moxalactam and ceftazidime, Antimicrob. Agents Chemother. 20:567.

    PubMed  CAS  Google Scholar 

  48. Kampf, D., Schurig, R., Korsukewitz, I., Bruckner, O., 1981, Cefoxitin pharmacokinetics: Relation to three different renal clearance studies in patients with various degrees of renal insufficiency, Antimicrob. Agents Chemother. 20:741.

    PubMed  CAS  Google Scholar 

  49. DeSante, K. A., Israel, K. S., Brier, G. L., Wolny, J. D., and Hatcher, B. L., 1982, Effect of probenecid on the pharmacokinetics of moxalactam, Antimicrob. Agents Chemother. 21:58.

    PubMed  CAS  Google Scholar 

  50. McKinney, T. D., Myers, P., and Speeg, K. V., 1981, Cimetidine secretion by rabbit renal tubules in vivo, Am. J. Physiol. 241:F69.

    CAS  Google Scholar 

  51. Bodemar, G., Norlander, B., and Walan, A., 1981, Pharmacokinetics of Cimetidine after single doses and during continuous treatment, Clin. Pharmacokinet. 6:306.

    Article  PubMed  CAS  Google Scholar 

  52. Weiner, I. and Roth, L., 1981, Renal excretion of Cimetidine, J. Pharmacol. Exp. Ther. 216:516.

    PubMed  CAS  Google Scholar 

  53. Ouslander, J. G., 1981, Drug therapy in the elderly, Ann. Intern. Med. 95:711.

    PubMed  CAS  Google Scholar 

  54. Vesell, E. S., 1980, The influence of host factors on drug response. II. Age, Rat Drug Ther. 14:1.

    Google Scholar 

  55. Murray, T. G., Chiang, S. T., Koepke, H. H., Walker, B. R., 1981, Renal Disease, age and oxazepam kinetics, Clin. Pharmacol. Ther. 30:805.

    Article  PubMed  CAS  Google Scholar 

  56. Bauer, L. A. and Blovin, R. A., 1981, Influence of age on tobramycin pharmacokinetics in patients with normal renal function, Antimicrob. Agents Chemother. 20:587.

    PubMed  CAS  Google Scholar 

  57. Kaufmann, B., Okay, A., Schaumann, W., Teufel, W., and Weib, W., 1981, Pharmacokinetics of metildigoxin and digoxin in geriatric patients with normal and elevated serum creatinine levels, Clin. Pharmacokinet. 6:463.

    Article  PubMed  CAS  Google Scholar 

  58. Schentag, J. J., Cerra, F. B., Calleri, G. M., Leising, M. E., French, M. A., and Bernhard, H., 1981, Age, disease and Cimetidine disposition in healthy subjects and chronically ill patients, Clin. Pharmacol. Ther. 29:737.

    Article  PubMed  CAS  Google Scholar 

  59. Drayer, D. E., Romankiewicz, J., Lorenzo, B., and Reidenberg, M. M., 1982, Age and renal clearance of Cimetidine, Clin. Pharmacol. Ther. 31:45.

    Article  PubMed  CAS  Google Scholar 

  60. Reidenberg, M. M., Camacho, M., Kluger, J., and Drayer, D. E., 1980, Aging decreases the renal clearance of procainamide and N-acetylprocainamide, Clin. Pharmacol. Ther. 28:732.

    Article  PubMed  CAS  Google Scholar 

  61. Ashraf, N., Locksley, R., and Arieff, A., 1981, Thiazide-induced hyponatremia associated with death or neurologic damage in outpatients, Am. J. Med. 70:1163.

    Article  PubMed  CAS  Google Scholar 

  62. Hallynck, T., Soep, H. H., Thomis, J., Boelaert, J., Daneeis, R., Fillastre, J. P., DeRosa, F., Rubinstein, E., Hatala, M., Spousta, J., and Dettli, L.,1981, Prediction of creatinine clearance from serum creatinine concentration based on lean body mass, Clin. Pharmacol. Ther. 30:414.

    Article  PubMed  CAS  Google Scholar 

  63. Cockroft, D. W. and Gault, M. H., 1976, Prediction of creatinine clearance from serum creatinine, Nephron 16:31.

    Article  Google Scholar 

  64. Hallynek, T., Soep, H. H., and Dettli, L., 1981, Influence of age and renal disease on aminoglycoside dosage, J. Antimicrob. Chemother. 8(Suppl. A): 109.

    Google Scholar 

  65. Vree, T. B., Guelen, P. J. M., Jongman-Nix, B., and Walenkamp, G., 1981, The relationship between the renal clearance of creatinine and the apparent renal clearance of beta-2-microglobulin in patients with normal and impaired kidney function, Clin. Chim. Acta. 114:93.

    Article  PubMed  CAS  Google Scholar 

  66. Vree, T. B., Hekster, Y. A., Hafkenscheid, J. C., van Dalen, R., and Friesen, W. T., 1981, The influence of urine flow on renal clearance of creatinine in patients with normal and impaired kidney function, Drug Intell. Clin. Pharm. 15:194.

    PubMed  CAS  Google Scholar 

  67. Hull, J. H., Hak, L. J., Koch, G. G., Wargin, W. A., Chi, S. L., and Mattocks, A. M., 1981, Influence of range of renal function and liver disease on predictability of creatinine clearance, Clin. Pharmacol. Ther. 29:516.

    Article  PubMed  CAS  Google Scholar 

  68. Ritschel, W. A., Banarer, M., Diaz, D., Margary, J. B., and Otero, J. D., 1980, Analog computer monitoring and evaluation of a dosing nomogram for gentamicin based on the C’min method, Part 1, Int. J. Clin. Pharmacol. Ther. Toxicol. 18:425.

    PubMed  CAS  Google Scholar 

  69. Evans, W. E., Taylor, R. H., Feldman, S., Crom, W. R., Rivera, G., and Yee, G. C., 1980, A model for dosing gentamicin in children and adolescents that adjusts for tissue accumulation with continuous dosing, Clin. Pharmacokinet. 5:295.

    Article  PubMed  CAS  Google Scholar 

  70. Zaske, D. E., Cipolle, R. J., and Strate, R. J., 1980, Gentamicin dosage requirements: Wide interpatient variations in 242 surgery patients with normal renal function, Surgery 87:164.

    PubMed  CAS  Google Scholar 

  71. Goetz, D. R., Pancorbo, S., Hoag, S., and Bloom, P., 1980, Prediction of serum gentamicin concentrations in patients undergoing hemodialysis, Am. J. Hosp. Pharm. 37:1077.

    PubMed  CAS  Google Scholar 

  72. Chennavasin, P., and Brater, D. C., 1981, Nomograms for drug use in renal disease, Clin. Pharmacokinet. 6:193.

    Article  PubMed  CAS  Google Scholar 

  73. Weiss, M., 1981, Residence time and accumulation of drugs in the body, Int. J. Clin. Pharmacol. Ther. Toxicol. 19:82.

    PubMed  CAS  Google Scholar 

  74. Paton, T. W., Manuel, M. A., and Saiphoo, C. S., 1981, Tobramycin disposition in continuous ambulatory peritoneal dialysis, Kidney Int. 19:393.

    Google Scholar 

  75. DePaepe, M., Lameire, N., Ringoir, S., Belpaire, F., and Bogaert, M., 1981, Peritoneal pharmacokinetics of gentamicin in rabbit and man, Int. J. Artif. Organs 5:447.

    Google Scholar 

  76. Poncorbo, S. and Comty, C., 1981, Pharmacokinetics of gentamicin in patients undergoing continuous ambulatory peritoneal dialysis, Antimicrob. Agents Chemother. 19:605.

    Google Scholar 

  77. Schurig, R., Kampf, D., Spieber, W., and Becker, H., 1981, Cefotaxime pharmacokinetics in peritoneal dialysis, Int. J. Artif. Organs 5:455.

    Google Scholar 

  78. Local, F. K., Munro, A. J., Kerr, D. N. S., and Sussman, M., 1981, Pharmacokinetics of intravenous and intraperitoneal cefuroxime in patients undergoing peritoneal dialysis, Clin. Nephrol. 16:40.

    PubMed  CAS  Google Scholar 

  79. Greaves, W., Kreeft, J. H., Ogilvie, R. I., and Richards, G. K., 1981, Cefoxitin disposition during peritoneal dialysis, Antimicrob. Agents Chemother. 19:253.

    PubMed  CAS  Google Scholar 

  80. Risler, T., Peters, V., Pablick, J., and Grabensee, B., 1981, Pharmacokinetics of digoxin and digitoxin in patients on CAPD, Int. J. Artif. Organs 5:452.

    Google Scholar 

  81. Brown, G. S., Lohr, T. O., Mayor, G. H., Freitag, J. J., Sanchez, T. V., and Prasad, J. M., 1981, Peritoneal clearance of theophylline, Am. J. Kidney Dis. 1:24.

    CAS  Google Scholar 

  82. Miceli, J. N., Clay, B., Fleischmann, L. E., Sarnaik, A. P., Aronow, R., and Done, A. K., 1980, Pharmacokinetics of severe theophylline intoxication managed by peritoneal dialysis, Dev. Pharmacol. Ther. 1:16.

    PubMed  CAS  Google Scholar 

  83. Czajka, P. A., Anderson, W. H., Christoph, R. A., and Banner, W., 1980, A pharmacokinetic evaluation of peritoneal dialysis for phenytoin intoxication, J. Clin. Pharm. 20:565.

    CAS  Google Scholar 

  84. Glew, R. H. and Pavuk, R. A., 1981, Stability of vancomycin and aminoglycoside antibiotics in peritoneal dialysis concentrate, Nephron 28:241.

    Article  CAS  Google Scholar 

  85. Khanna, R., Oreopoulos, D. G., Vas, S., McCready, W., and Dombros, N., 1980, Fungal peritonitis in patients undergoing chronic intermittent or continuous ambulatory peritoneal dialysis, Proc. Eur op. Dialysis Transplant Assoc. 17:291.

    CAS  Google Scholar 

  86. Larsson, R., Erlanson, P., Bodemar, G., Norlander, B., Fransson, L., and Strouth, L., 1982, Pharmacokinetics of Cimetidine and its sulphoxide metabolite during hemodialysis, Eur. J. Clin. Pharm. 21:325.

    Article  CAS  Google Scholar 

  87. Kradjan, W. A., Martin, T. R., Delancy, C. J., Blair, A. D., and Cutler, R. E., 1982, Effect of hemodialysis on the pharmacokinetics of theophylline in chronic renal failure, Nephron 32:40.

    Article  PubMed  CAS  Google Scholar 

  88. Wang, L. H., Lee, C. S., Majeske, B. L., and Marbury, T. C., 1981, Clearance and recovery calculations in hemodialysis: Application to plasma, red blood cell and dialysate measurements of cyclophosphamide, Clin. Pharmacol. Ther. 29:365.

    Article  PubMed  CAS  Google Scholar 

  89. Giacomini, K. M., Gibson, T. P., and Levy, G., 1980, Effect of hemodialysis on propoxyphene and norpropoxyphene concentrations in blood of anephric patients, Clin. Pharmacol. Ther. 27:508.

    Article  PubMed  CAS  Google Scholar 

  90. Gugler, R. and von Unruh, G. E., 1980, Clinical pharmacokinetics of valproic, Acid Clin. Pharmacokinet. 5:67.

    Article  CAS  Google Scholar 

  91. Marbury, T. C., Lee, C. S., Bruni, J., and Wilder, B. J., 1980, Hemodialysis of valproic acid in uremic patients, Dial. Transplant 9:961.

    Google Scholar 

  92. Rosenberg, J., Benowitz, N. L., and Pond, S., 1981, Pharmacokinetics of drug overdose, Clin. Pharmacokinet. 6:161.

    Article  PubMed  CAS  Google Scholar 

  93. Vaziri, N. D., Upham, T., and Barton, C. H., 1980, Hemodialysis clearance of arsenic, Clin. Toxicol. 17:451.

    Article  PubMed  CAS  Google Scholar 

  94. Gelfand, M. C. and Winchester, J. F., 1980, Hemoperfusion in drug overdosage: A technique when conservative management is not sufficient, Clin. Toxicol. 17:583.

    Article  PubMed  CAS  Google Scholar 

  95. Rosenbaum, J. L., 1980, Hemoperfusion for acute drug intoxication, Kidney Int. 18:S106.

    Google Scholar 

  96. DeBroe, M., Verpooten, G. A., Christiaens, M. A., Rutsaert, R. J-, Holvoet, J., Nagler, J., and Heyndrickx, A., 1981, Clinical experience with prolonged combined hemoperfusion-hemodialysis treatment of severe poisoning, Artif. Organs 5:59.

    CAS  Google Scholar 

  97. Baehler, R. W., Work, J., Smith, W., and Dominic, J. A., 1980, Charcoal hemoperfusion in the therapy for methsuximide and phenytoin overdose, Arch. Intern. Med. 140:1466.

    Article  PubMed  CAS  Google Scholar 

  98. Benowitz, N., Abolin, C., Tozer, T., Rosenberg, J., Rogers, W., Pond, S., Schoenfeld, P., and Humphreys, M., 1980, Resin hemoperfusion in ethchlorvynol overdose, Clin. Pharmacol. Ther. 27:236.

    Article  PubMed  CAS  Google Scholar 

  99. Zmuda, M., 1980, Resin hemoperfusion in dogs intoxicated with ethchlor-vynol (Placidyl), Kidney Int. 17:303.

    Article  PubMed  CAS  Google Scholar 

  100. Gosselin, B., Mathieu, D., Chopin, C., Wattel, F., Dupuis, B., Haguenoer, J. M., and Desprez, M., 1980, Acute intoxication with diisopyramide: Clinical and experimental study by hemoperfusion on amberlite XAD 4 resin, Clin. Toxicol. 17:439.

    Article  PubMed  CAS  Google Scholar 

  101. Crome, P. and Widdop, B., 1980, Resin hemoperfusion in tricyclic antidepressant poisoning, Lancet 1:306.

    Article  PubMed  CAS  Google Scholar 

  102. Hoy, W. E., Rivero, A., Marin, M. G., and Rieders, F., 1980, Resin hemoperfusion for treatment of a massive meprobamate overdose, Ann. Intern. Med. 93:455.

    PubMed  CAS  Google Scholar 

  103. Weinberger, M. and Hendeles, L., 1980, Role of dialysis in the management and prevention of theophylline toxicity, Dev. Pharmacol. Ther. 1:26.

    PubMed  CAS  Google Scholar 

  104. Winchester, J. F., Gelfand, M. C., Helliwell, M., Vale, J. A., Goulding, R., and Schreiner, G. E., 1981, Extracorporeal treatment of salicylate or acetaminophen poisoning—Is there a role? Arch. Intern. Med. 141:370.

    Article  PubMed  CAS  Google Scholar 

  105. Smiley, J. W., Del Guercico, E. T., and March, N. M., 1980, Hemoperfusion in digoxin toxicity, Dial. Transplant 9:375.

    Google Scholar 

  106. Gibson, T. P., 1980, Comparison of XAD-4 and charcoal hemoperfusion for removal of digoxin and digitoxin, Kidney Int. 18:S101.

    Google Scholar 

  107. Russo, M. E. and Atkin-Thor, E., 1981, Gentamicin and ticarcillin in subjects with end-stage renal disease, Clin. Nephrol. 15:175.

    PubMed  CAS  Google Scholar 

  108. Farchione, L. A., 1981, Inactivation of aminoglycosides by penicillins, J. Antimicrob. Chemother. 8:27.

    PubMed  CAS  Google Scholar 

  109. Pickering, L. K. and Rutherford, I., 1981, Effect of concentration and time upon inactivation of tobramycin, gentamicin, mezlocillin and piperacillin, J. Pharmacol. Exp. Ther. 217:345.

    PubMed  CAS  Google Scholar 

  110. Thompson, M., Russo, M. E., Saxon, B., Atkin-Thor, E., and Matsen, J. M., 1982, Gentamicin inactivation by piperacillin or carbenicillin in patients with end-stage renal disease, Antimicrob. Agents Chemother. 21:268.

    PubMed  CAS  Google Scholar 

  111. Chow, M. S., Quintiliani, R., and Nightingale, C. H., 1981, In vivo inactivation of tobramycin by ticarcillin, JAMA 247:658.

    Article  Google Scholar 

  112. Mungall, D. R., Robichaux, R. P., Perry, W., Scott, J. W., Robinson, A., Burelle, T., and Hurst, D., 1980, Effects of quinidine on serum digoxin concentration, Ann. Intern. Med. 93:689.

    PubMed  CAS  Google Scholar 

  113. Leahey, E. B., Reiffel, J. A., Giarina, E. V., and Bigger, J. T., 1980, The effect of quinidine and other oral antiarrhythmics on serum digoxin, Ann. Intern. Med. 92:605.

    PubMed  Google Scholar 

  114. Hansten, P. D., 1981, Quinidine and digoxin, Drug Interact. Newsletter 1:13.

    Google Scholar 

  115. Fenster, P. E., Hager, W. D., and Powell, J. R., 1982, Effect of renal failure on the digoxinquinidine interaction, Clin. Res. 30:25A.

    Google Scholar 

  116. Doering, W., Fichtl, B., Herrmann, M., and Besenfelder, E., 1982, Quin-idine-digoxin interaction: Evidence for involvement of an extrarenal mechanism, Eur. J. Clin. Pharmacol. 21:281.

    Article  PubMed  CAS  Google Scholar 

  117. Ochs, H. R., Bodem, G., and Greenblatt, D. J., 1981, Impairment of digoxin clearance by coadministration of quinidine, J. Clin. Pharmacol. 21:396.

    PubMed  CAS  Google Scholar 

  118. Hirschberg, R., Schaefer, K., von Herrath, D., Kreutz, G., and Kewitz, H., 1981, Digoxin-quinidine interaction in patients with renal failure, Klin. Wochenschr. 59:521.

    Article  PubMed  CAS  Google Scholar 

  119. Wandell, M., Powell, J. R., Hager, W. D., Fenster, P. E., Graves, P. E., Conrad, K. A., and Goldman, S., 1980, Effect of quinine on digoxin kinetics, Clin. Pharmacol. Ther. 28:425.

    Article  PubMed  CAS  Google Scholar 

  120. Ochs, H. R., Pabst, J., Greenblatt, D. J., and Dengler, H. J., 1980, Noninteraction of digitoxin and quinidine, N. Engl. J. Med. 303:672.

    Article  PubMed  CAS  Google Scholar 

  121. Pedersen, K. E., Dorph-Pedersen, A., Hvidt, S., Klitgaard, N. A., and Nielsen-Kudsk, F., 1981, Digoxin-verapamil interaction, Clin. Pharmacol. Ther. 30:311.

    Article  PubMed  CAS  Google Scholar 

  122. Brown, D. D., Spector, R., and, Juhl, R. P., 1980, Drug interactions with digoxin, Drugs 20:198.

    Article  PubMed  CAS  Google Scholar 

  123. Hansten, P. D., 1981, Furosemide and indomethacin, Drug Interact. Newsletter 1:1.

    Google Scholar 

  124. Hansten, P. D., 1981, Furosemide and ibuprofen, Drug Interact. Newsletter 1:48.

    Google Scholar 

  125. Hansten, P. D., 1981, Lithium and indomethacin, Drug Interact. Newsletter 1:47.

    Google Scholar 

  126. Frolich, J. C., and Reimann, I. W., 1981, Effects of diclofenac on lithium kinetics, Clin. Pharmacol. Ther. 30:348.

    Article  PubMed  Google Scholar 

  127. Sherman, R. A., Eisinger, R. P., Weinstein, M. P., and Samuel, J., 1981, Cefoxitin-induced pseudo acute renal failure, Clin. Therapeut. 4:110.

    Google Scholar 

  128. Durham, S. R., Bignell, A. H. C., and Wise, R., 1979, Interference of cefoxitin in the creatinine estimation and its clinical relevance, J. Clin. Path. 32:1148.

    Article  PubMed  CAS  Google Scholar 

  129. Reddy, J. and Bailey, R. R., 1981, Cefoxitin-associated renal failure, N. Z. Med. J. 93:337.

    PubMed  CAS  Google Scholar 

  130. Molitch, M., Rodman, E., Hirsch, C. A., and Dubinsky, E., 1980, Spurious serum creatinine elevations in ketoacidosis, Ann. Intern. Med. 93:280.

    PubMed  CAS  Google Scholar 

  131. Whelton, A. and Neu, H. (eds.), 1982, The Aminoglycosides, Dekker, New York.

    Google Scholar 

  132. Burkle, W. S., 1981, Comparative evaluation of the aminoglycoside antibiotics for systemic use, Drug Intell. Clin. Pharm. 15:847.

    PubMed  CAS  Google Scholar 

  133. Meyer, R. D., 1981, Amikacin, Ann. Intern. Med. 95:328.

    PubMed  CAS  Google Scholar 

  134. Schentag, J. J., Jusko, W. J., Plaut, M. E., Cumbo, T. J., Vance, J. W., and Abrutyn, E., 1977, Tissue persistence of gentamicin in man, JAMA 238:327.

    Article  PubMed  CAS  Google Scholar 

  135. Schentag, J. J., Lasezkay, G., Cumbo, T. J., Plaut, M. E., and, Jusko, W. J., 1978, Accumulation pharmacokinetics of tobramycin, Antimkrob. Agents Chemother. 13:649.

    CAS  Google Scholar 

  136. Luft, F. C., Yum, M. N., and Kleit, S. A., 1976, Comparative nephrotoxicities of netilmicin and gentamicin in rats, Antimkrob. Agents Chemother. 10:845.

    CAS  Google Scholar 

  137. Edwards, D. J., Mangione, A., Cumbo, T. J., and Schentag, J. J., 1981, Predicted tissue accumulation of netilmicin in patients, Antimkrob. Agents Chemother. 20:714.

    CAS  Google Scholar 

  138. Kahlmeter, G., 1980, Netilmicin: Clinical pharmacokinetics and aspects on dosage schedules. An overview, Scand. J. Infect. Dis. 23(Suppl.):74.

    Google Scholar 

  139. Smith, C. R., Lipsky, J. J., Laskin, O. L., Hellmann, D. B., Mellitus, E. D., Longstretch, J., and Lietman, P. S., 1980, Double-blind comparison of the nephrotoxicity and auditory toxicity of gentamicin and tobramycin, N. Engl. J. Med. 302:1106.

    Article  PubMed  CAS  Google Scholar 

  140. Bock, B. V., Edelstein, P., and Meyer, R. D., 1980, Prospective comparative study of the efficacy and toxicity of netilmicin and amikacin, Antimkrob. Agents Chemother. 17:217.

    CAS  Google Scholar 

  141. Wade, J. C., Schimpff, S., and Wiernik, P. H., 1981, Antibiotic combination-associated nephrotoxicity in granulocytopenic patients with cancer, Arch. Intern. Med. 141:1789.

    Article  PubMed  CAS  Google Scholar 

  142. Prince, R. A., Ling, M. H., Hepler, C. D., Rainville, E. C., Kealey, G. P., Donta, S. T., Le Frock, J. L., and Kowalsky, S. F., 1980, Factors associated with creatinine clearance changes following gentamicin therapy, Am. J. Hosp. Pharmacol. 37:1489.

    CAS  Google Scholar 

  143. Cipolle, R. J., Scifert, R. D., Zaske, D. E., and Strate, R. G., 1980, Systematically individualizing tobramycin dosing regimens, J. Clin. Pharmacol. 20:570.

    PubMed  CAS  Google Scholar 

  144. Goto, M., Sugiyama, M., and Ishizaki, T., 1980, Pharmacokinetic studies with dibekacin, a new aminoglycoside, after intravenous and intramuscular administration to human volunteers, Antimkrob. Agents Chemother. 18:372.

    CAS  Google Scholar 

  145. Kusumi, R., Metzler, C., and Fass, R., 1981, Pharmacokinetics of spectinomycin in volunteers with renal insufficiency, Chemotherapy 27:95.

    Article  PubMed  CAS  Google Scholar 

  146. Follath, F., Wenk, M., and Vozeh, S., 1981, Plasma concentration and monitoring of aminoglycosides, J. Antimicrobial. Chemother. 8(Suppl. A):7.

    Google Scholar 

  147. Bennett, W. M., Plamp, C. E., Elliott, W. C., Parker, R. A., and Porter, G. A., 1982, Effect of basic amino acids and aminoglycosides on 3H gentamicin uptake in cortical slices of rat and human kidney, J. Lab. Clin. Med. 99:156.

    PubMed  CAS  Google Scholar 

  148. Bennett, W. M., Plamp, C. E., Gilbert, D. N., Parker, R. A., and Porter, G. A., 1979, The influence of dosage regimen on experimental gentamicin nephrotoxicity: Dissociation of peak serum levels from renal failure, J. Infect. Dis. 140:576.

    Article  PubMed  CAS  Google Scholar 

  149. Murray, B. and Moellering, R. C., 1981, Cephalosporins, Ann. Rev. Med. 32:559.

    Article  PubMed  CAS  Google Scholar 

  150. Rotschafer, J. C., Crossley, K. B., Lesar, T. S., Zaske, D., and Miller, K., 1982, Cefaclor pharmacokinetic parameters: Serum concentrations determined by a new high-performance liquid chromatographic technique, Antimkrob. Agents Chemother. 21:170.

    CAS  Google Scholar 

  151. Deny, J. E., 1981, Evaluation of cefaclor, Am. J. Hosp. Pharmacol. 38:54.

    Google Scholar 

  152. Spyker, D. A., Gober, L. L., Scheid, M., Sande, M. A., and Bolton, W. K., 1982, Pharmacokinetics of cefaclor in renal failure: Effects of multiple doses and hemodialysis, Antimicrob. Agents Chemother. 21:278.

    PubMed  CAS  Google Scholar 

  153. Esmieu, F., Guibert, J., Rosenkilde, H. C., Ho, I., and Le Go, A., 1980, Pharmacokinetics of cefotaxime in normal volunteers, J. Antimicrob. Chemother. 6(Suppl. A):83.

    Article  PubMed  CAS  Google Scholar 

  154. Fulastre, J. P., Leroy, A., Humbert, G., and Godin, M., 1980, Pharmacokinetics of cefotaxime in subjects with normal and impaired renal function, J. Antimicrob. Chemother. 6(Suppl. A): 103.

    Google Scholar 

  155. Wise, R., Wright, N., and Wills, P. J., 1981, Pharmacology of cefotaxime and its desacetyl metabolite in renal and hepatic disease, Antimicrob. Agents Chemother. 19:526.

    PubMed  CAS  Google Scholar 

  156. Bolton, W. K., Scheid, W. M., Spyker, D. A., and Sande, M. A., 1981, Pharmacokinetics of cefoperazone in normal volunteers and subjects with renal insufficiency, Antimicrob. Agents Chemother. 19:821.

    PubMed  CAS  Google Scholar 

  157. Bailey, R. R., Peddie, B., and Blake, E., 1981, Serum and urine concentrations of cefoperazone in severe chronic renal failure, Drugs 22(Suppl. 1):46.

    Article  PubMed  Google Scholar 

  158. Craig, W. A. and Gerber, A. U., 1981, Pharmacokinetics of cefoperazone: A review, Drugs 22(Suppl. 1):35.

    Article  PubMed  CAS  Google Scholar 

  159. Hawkins, S. S., Alford, R. H., Stone, W. J., Smyth, R. D., and Pfeffer, M., 1981, Ceforanide kinetics in renal insufficiency, Clin. Pharmacol. Ther. 30:468.

    Article  PubMed  CAS  Google Scholar 

  160. Pfeffer, M., Gaver, R. C., and Van Harken, D. R., 1980, Human pharmacokinetics of a new broad spectrum parenteral cephalosporin antibiotic, ceforanide, J. Pharmacol Sci. 69:398.

    Article  CAS  Google Scholar 

  161. Hess, J. R., Berman, S. J., Boughton, W. H., Sugihara, J. G., Musgrave, J. E., Wong, E. C., and Siemsen, A. M., 1980, Pharmacokinetics of ceforanide in patients with end stage renal disease on hemodialysis, Antimicrob. Agents Chemother. 17:251.

    PubMed  CAS  Google Scholar 

  162. Greaves, W. L., Kreeft, J. H., Ogilvie, R. I., and Richards, G. K., 1981, Cefoxitin disposition during peritoneal dialysis, Antimicrob. Agents Chemother. 19:253.

    PubMed  CAS  Google Scholar 

  163. Srinivasan, S. and Neu, H., 1981, Pharmacokinetics of moxalactam in patients with renal failure and during hemodialysis, Antimicrob. Agents Chemother. 20:398.

    PubMed  CAS  Google Scholar 

  164. Peterson, L., Bean, B., Fasching, C. E., Korchik, W. P., and Gerding, D. N., 1981, Pharmacokinetics, protein binding and predicted extravascular distribution of moxalactam in normal and renal failure subjects, Antimicrob. Agents Chemother. 20:378.

    PubMed  CAS  Google Scholar 

  165. Aronoff, G. R., Sloan, R. S., Mong, S. A., Luft, F. C., and Kleit, S. A., 1981, Moxalactam pharmacokinetics during hemodialysis, Antimicrob. Agents Chemother. 19:575.

    PubMed  CAS  Google Scholar 

  166. Lam, M., Marion, C. V., and Czerwinski, A. W., 1981, Pharmacokinetics of moxalactam in patients wtih renal insufficiency, Antimicrob. Agents Chemother. 19:461.

    PubMed  CAS  Google Scholar 

  167. Jacobson, E. J., Zahrowski, J. J., and Nissenson, A. R., 1981, Moxalactam kinetics in hemodialysis, Clin. Pharmacol. Ther. 30:487.

    Article  PubMed  CAS  Google Scholar 

  168. Leroy, A., Humbert, G., and Fulastre, J. P., 1981, Pharmacokinetics of moxalactam in subjects with normal and impaired renal function, Antimicrob. Agents Chemother. 19:965.

    PubMed  CAS  Google Scholar 

  169. Bolton, W. K., Scheid, W. M., Spyker, D. A., Overby, T. L., and Sande, M. A., 1980, Pharmacokinetics of moxalactam in subjects with various degrees of renal dysfunction, Antimicrob. Agents Chemother. 18:933.

    PubMed  CAS  Google Scholar 

  170. Leroy, A., Humbert, G., Godin, M., and Fulastre, J. P., 1980, Pharmacokinetics of azlocillin in subjects with normal and impaired renal function, Antimicrob. Agents Chemother. 17:344.

    PubMed  CAS  Google Scholar 

  171. Aletta, J. M., Francke, E. F., and Neu, H. C., 1980, Intravenous azlocillin kinetics in patients on long-term hemodialysis, Clin. Pharmacol. Ther. 27:563.

    Article  PubMed  CAS  Google Scholar 

  172. Janicke, D. M., Mangione, A., Schultz, R. W., and, Jusko, W. J., 1981, Mezlocillin disposition in chronic hemodialysis patients, Antimicrob. Agents Chemother. 20:590.

    PubMed  CAS  Google Scholar 

  173. Kampf, D. R., Schurig, K., Weihermuller, K., and Forster, D., 1980, Effects of impaired renal function, hemodialysis and peritoneal dialysis on the pharmacokinetics of mezlocillin, Antimicrob. Agents Chemother. 18:81.

    PubMed  CAS  Google Scholar 

  174. Frimodt-Moller, N., Maigaard, S., Toothaker, R. D., Bundtzen, R. W., Brodey, M. V., Craig, W. A., Welling, P. G., and Madsen, P. O., 1980, Mezlocillin pharmacokinetics after single intravenous doses to patients with varying degrees of renal function, Antimicrob. Agents Chemother. 17:599.

    PubMed  CAS  Google Scholar 

  175. Aronoff, G.R., Sloan, R. S., Luft, F. C., Nelson, R. L., Maxwell, D. R., and Kleit, S., 1980, Mezlocillin pharmacokinetics in renal impairment, Clin. Pharmacol. Ther. 28:523.

    Article  PubMed  CAS  Google Scholar 

  176. George, C. R. P., Burgoyne, J., Funnell, G. R., Robinson, P., Collignon, P., Meads, K., and Guinness, M., 1981, Pharmacokinetics of piperacillin in renal failure, Med. J. Aust. 1:35.

    Google Scholar 

  177. Giron, J. A., Meyers, B. R., Hirschman, S. Z., and Srulevitch, E., 1981, Pharmacokinetics of piperacillin in patients with moderate renal failure and in patients undergoing hemodialysis, Antimicrob. Agents Chemother. 19:279.

    PubMed  CAS  Google Scholar 

  178. Thompson, M., Russo, M. E., Matsen, J. M., and Atkin-Thor, E., 1981, Piperacillin pharmacokinetics in subjects with chronic renal failure, Antimicrob. Agents Chemother. 19:450.

    PubMed  CAS  Google Scholar 

  179. Trollfors, B., Suurkula, M., Price, J. D., and Norrby, R., 1980, Renal function during cefuroxime treatment in patients with pre-existing renal impairment, J. Antimicrob. Chemother. 6:665.

    Article  PubMed  CAS  Google Scholar 

  180. Nemati, C. and Abuelo, J. G., 1981, Cephalosporin-induced hypersensitivity nephritis: Report of a case caused by cefazolin, I. Med. J. 64:91.

    CAS  Google Scholar 

  181. Anonymous, 1981, Mezlocillin sodium, Med. Lett. 23:109.

    Google Scholar 

  182. Ohkawa, M., Sugata, T., Sawaki, M., Okasho, A., Kuroda, K., and Yamada, H., 1981, Pharmacokinetics of Cinoxacin in normal volunteers and patients with impaired renal function, J. Antimicrob. Chemother. 8:447.

    Article  PubMed  CAS  Google Scholar 

  183. Anonymous, 1981, Cinoxacin—A new drug for urinary tract infections, Med. Lett. 23:57.

    Google Scholar 

  184. Brass, C., Galgiani, J. N., Blaschke, T. F., DeFelice, R., O’Reilly, R. A., and Stevens, D. A., 1982, Disposition of ketoconazole, an oral antifungal, in humans, Antimicrob. Agents Chemother. 21:151.

    PubMed  CAS  Google Scholar 

  185. Horadam, V., Sharp, J. G., Smilack, J. D., McAnalley, B. H., Garriott, J. C., Stephens, M. K., Prati, R. C., and Brater, D. C., 1981, Pharmacokinetics of amantamidine hydrochloride in subjects with normal and impaired renal function, Ann. Intern. Med. 94:454.

    PubMed  CAS  Google Scholar 

  186. Soung, L., Ing, T., Daugirdas, J. T., Wu, M., Gandhi, V., Ivanovich, P. T., Hano, J. E., and Viol, G. W., 1980, Amantadine hydrochloride pharmacokinetics in hemodialysis patients, Ann. Intern. Med. 93:46.

    PubMed  CAS  Google Scholar 

  187. Brigden, D., Bye, A., and Fowle, A. S. E., 1981, Human pharmacokinetics of acyclovir (an antiviral agent) following rapid intravenous injection, J. Antimicrob. Chemother. 7:399.

    Article  PubMed  CAS  Google Scholar 

  188. Andrew, O. T., Schoenfeld, P. Y., Hopewell, P. C., and Humphreys, M. H., 1980, Tuberculosis in patients with end-stage renal disease, Am. J. Med. 68:59.

    Article  PubMed  CAS  Google Scholar 

  189. Finegold, S., 1980, Metronidazole, Ann. Intern. Med. 93:585.

    PubMed  CAS  Google Scholar 

  190. Goldman, P., 1980, Metronidazole, N. Engl. J. Med. 303:1212.

    Article  PubMed  CAS  Google Scholar 

  191. Anonymous, 1981, Metronidazole, Med. Lett. 23:13.

    Google Scholar 

  192. Miller, P. D., Linas, S. L., and Schrier, R. W., 1980, Plasma demeclocycline levels and nephrotoxicity, JAMA 243:2513.

    Article  PubMed  CAS  Google Scholar 

  193. Moellering, R. C., Krogstad, D. J., and Greenblatt, D. J., 1981, Vancomycin therapy in patients with impaired renal function: A nomogram, Ann. Intern. Med. 94:343.

    PubMed  Google Scholar 

  194. Patel, R. B. and Welling, P. G., 1980, Clinical pharmacokinetics of cotrimoxazole (trimethoporim-sulphamethoxazole), Clin. Pharmacokinet. 5:405.

    Article  PubMed  CAS  Google Scholar 

  195. Bradley, P. P., Warden, G. D., Maxwell, J. G., and Rothstein, G., 1980, Neutropenia and thrombocytopenia in renal allograft recipients treated with trimethoprimsulfamethoxazole, Ann. Intern. Med. 93:560.

    PubMed  CAS  Google Scholar 

  196. Opie, L. H., 1980, Digitalis and sympathomimetic stimulants, Lancet 1:912.

    PubMed  CAS  Google Scholar 

  197. Vohringer, H. F. and Rietbrock, N., 1981, Digitalis therapy in renal failure with special reference to digitoxin, Int. J. Clin. Pharmacol. Ther. Toxicol. 19:175.

    PubMed  CAS  Google Scholar 

  198. Gault, M. H., Churchill, D. N., and Karla, J., 1980, Loading dose of digoxin in renal failure, Br. J. Clin. Pharm. 9:593.

    CAS  Google Scholar 

  199. Ohnhaus, E. E., Lenzinger, H. R., and Galeazzi, R. L., 1980, Comparison of two different loading doses of digoxin in severe renal impairment, Eur. J. Clin. Pharm. 18:467.

    Article  CAS  Google Scholar 

  200. Keller, F., Molzatin, M., and Ingerowski, R., 1980, Digoxin dosage in renal insufficiency: Impracticality of basing it on the creatinine clearance, body weight and volume of distribution, Eur. J. Clin. Pharm. 18:433.

    Article  CAS  Google Scholar 

  201. Lindenbaum, J., Tse-Eng, J., Butler, V. P., and Rund, D. G., 1981, Urinary excretion of reduced metabolites of digoxin, Am. J. Med. 71:67.

    Article  PubMed  CAS  Google Scholar 

  202. Gibson, T.P. and Nelson, H. A., 1980, The question of cumulation of digoxin metabolites in renal failure, CLin. Pharmacol. Ther. 27:219.

    Article  PubMed  CAS  Google Scholar 

  203. Colburn, W., 1980, Specific antibodies and Fab fragments to alter the pharmacokinetics and reverse the pharmacologic/toxicologic effects of drugs, Drug Metab. Rev. 11:223.

    Article  PubMed  CAS  Google Scholar 

  204. Singh, B. N., Cho, Y. W., and Kuemmerle, H. P., 1981, Clinical pharmacology of antiarrhythmic drugs: A review and overview, Part 1, Int. J. Clin. Pharmacol. Ther. Toxicol. 19:139.

    PubMed  Google Scholar 

  205. Opie, L. H., 1980, Antiarrhythmic agents, Lancet 1:861.

    Article  PubMed  CAS  Google Scholar 

  206. Kluger, J., Drayer, D., Reidenberg, M., Ellis, G., Lloyd, V., Tyberg, T., and Hayes, J., 1980, The clinical pharmacology and antiarrhythmic efficacy of acetylprocainamide in patients with arrhythmias, Am. J. Cardiol. 45:1250.

    Article  PubMed  CAS  Google Scholar 

  207. Koden, D. M., Reele, S. B., Higgins, S. B., Wilkinson, G. R., Smith, R. F., Oates, J. A., and Woosley, R. L., 1980, Antiarrhythmic efficacy, pharmacokinetics and safety of N-acetylprocainamide in human subjects: Comparison with procainamide, Am. J. Cardiol. 46:463.

    Article  Google Scholar 

  208. Ruo, T., Morita, Y., Atkinson, A., Henthorn, T., and Thenot, J. P., 1981, Identification of desethylprocainamide in patients: A new metabolite of procainamide, J. Pharmacol. Exp. Ther. 216:357.

    PubMed  CAS  Google Scholar 

  209. Sevka, M., Matthews, S. J., Nightingale, C. H., Izard, M. W., Fieldman, A., and Chow, M. S., 1981, Disopyramide hemodialysis and kinetics in patients requiring long-term hemodialysis, Clin. Pharmacol. Ther. 29:322.

    Article  PubMed  CAS  Google Scholar 

  210. Johnston, A., Henry, J. A., Warrington, S. J., and Hamer, N. A., 1980, Pharmacokinetics of oral disopyramide phosphate in patients with renal impairment, Br. J. Clin. Pharmacol. 10:245.

    PubMed  CAS  Google Scholar 

  211. Zelis, R. F., 1981, Calcium entry blockers in cardiologic therapy, Hosp. Practice 17:49.

    Google Scholar 

  212. Keefe, D. L., Yee, Y. G., and Kates, R., 1981, Verapamil protein binding in patients and normal subjects, Clin. Pharmacol. Ther. 29:21.

    Article  PubMed  CAS  Google Scholar 

  213. Koike, Y., Shimamura, K., Shudo, I., and Saito, H., 1979, Pharmacokinetics of verapamil in man, Res. Comm. Chem. Path. Pharmacol. 24:37.

    CAS  Google Scholar 

  214. Baudinet, G., Henrard, L., Quinaux, N., El Allaf, D., DeLandsheere, C., Carlier, J., and Dresse, A., 1980, Mexilitene, Acta Cardiologica 25(Suppl.):55.

    PubMed  Google Scholar 

  215. Ronfeld, R., 1980, Comparative pharmacokinetics of new antiarrhythmic drugs, Am. Heart J. 100:978.

    Article  PubMed  CAS  Google Scholar 

  216. Gerber, J. G., 1981, Antihypertensive agents and diuretics, in: Clinical Use of Drugs in Patients with Liver and Kidney Disease (R. Anderson and R. Schrier, eds.), W. B. Saunders, Philadelphia, p. 211.

    Google Scholar 

  217. Onoyama, K., Hirakata, H., Iseki, K., Fujimi, S., Omar, T., Kobayaski, M., and Kawahara, Y., 1981, Blood concentration and urinary excretion of Captopril (SE 14225) in patients with chronic renal failure, Hypertension 3:456.

    PubMed  CAS  Google Scholar 

  218. Hirakata, H., Onoyama, K., Iseki, K., Omar, T., Fujimi, S., and Kawahara, Y., 1981, Captopril (SQ 14225) clearance during hemodialysis treatment, Clin. Nephrol. 16:321.

    PubMed  CAS  Google Scholar 

  219. Gavras, I., Graff, L. G., Rose, B. D., McKenna, J. M., Gavras, H., and Brunner, H. R., 1981, Fatal pancytopenia associated with the use of Captopril, Ann. Intern. Med. 94:58.

    PubMed  CAS  Google Scholar 

  220. Waeber, B., Gavras, I., Brunner, H. R., and Gavras, H., 1981, Safety and efficacy of chronic therapy with Captopril in hypertensive patients: An update, J. Clin. Pharmacol. 21:508.

    PubMed  CAS  Google Scholar 

  221. Vidt, D. G., Bravo, E. L., and Fouad, F. M., 1982, Captopril, N. Engl. J. Med. 306:214.

    Article  PubMed  CAS  Google Scholar 

  222. Warren, S. E. and O’Connor, D. T., 1982, Hyperkalemia resulting from Captopril administration, JAMA 244:2551.

    Article  Google Scholar 

  223. Hogan, M. J., Wallin, J. D., and Chu, L. C., 1981, Plasma Clonidine concentration and pharmacologic effect, Clin. Pharmacol. Ther. 30:729.

    Article  PubMed  CAS  Google Scholar 

  224. Lowenthal, D. T., 1980, Pharmacokinetics of Clonidine, J. Cardiovasc. Pharmacol. 2(Suppl. 1):S29.

    Article  CAS  Google Scholar 

  225. Itzkovitz, H. D., 1980, Clonidine and the kidney, J. Cardiovasc. Pharmacol. 2(Suppl. 1):S47.

    Article  Google Scholar 

  226. Reece, P. A., 1981, Hydralazine and related compounds: Chemistry, metabolism and mode of action, Med. Res. Rev. 1:73.

    Article  PubMed  CAS  Google Scholar 

  227. Ludden, T. M., Shepherd, A. M. M., McNay, J. L., and Lin M. S., 1980, Hydralazine kinetics in hypertensive patients after intravenous administration, Clin. Pharm. Ther. 28:736.

    Article  CAS  Google Scholar 

  228. Tjandamaga, T. B., 1980, Altered pharmacokinetics of beta-adrenoreceptor blocking drugs in patients with renal insufficiency, Arch. Int. Pharmacodyn. Ther. (Suppl.):38.

    Google Scholar 

  229. Sundquist, H., 1980, Basic review and comparison of beta-blocker pharmacokinetics, Curr. Ther. Res. 28(Suppl.):38.

    CAS  Google Scholar 

  230. Shanks, R. G., 1980, Clinical implications of beta blocker pharmacokinetics, Curr. Ther. Res. 28(Suppl.):51.

    Google Scholar 

  231. Gugler, R., 1980, The pharmacokinetic properties of beta adrenoreceptor blocking drugs, Arch. Int. Pharmacodyn. Ther. (Suppl.):27.

    Google Scholar 

  232. Lowenthal, D. T., 1978, Timolol pharmacokinetics in chronic renal insufficiency, Clin. Pharmacol. Ther. 23:606.

    PubMed  CAS  Google Scholar 

  233. Tocco, D. L., Duncan, A. E. W., Deluna, F. A., Hucker, H. B., Gruber, V. F., and Vandenheuvel, W. J. A., 1975, Physiological disposition and metabolism of timolol in man and laboratory animals, Drug. Metab. Disp. 3:38.

    Google Scholar 

  234. Else, O. F., Sorenson, H., and Edwards, I. R., 1978, Plasma timolol levels oral and intravenous administration, Eur. J. Clin. Pharm. 14:431.

    Article  CAS  Google Scholar 

  235. Anonymous, 1980, Naldolol (Corgard)—A new beta blocker, Med. Lett. 22:33.

    Google Scholar 

  236. Frishman, W. H., 1981, Naldolol: A new beta-adrenoreceptor antagonist, N. Engl. J. Med. 305:678.

    Article  PubMed  CAS  Google Scholar 

  237. Blair, A. D., Burgess, E. D., Maxwell, B. M., and Cutler, R. E., 1981, Sotalol kinetics in renal insufficiency, Clin. Pharmacol. Ther. 29:457.

    Article  PubMed  CAS  Google Scholar 

  238. McLeod, A. A. and Shand, D. G., 1982, Atenolol: A long acting beta1-adrenoceptor antagonist, Ann. Intern. Med. 96:244.

    PubMed  CAS  Google Scholar 

  239. McAinsh, J., Holmes, B. F., Smith, S., Hood, D., and Warren, D., 1980, Atenolol kinetics in renal failure, Clin. Pharmacol. Ther. 28:302.

    Article  PubMed  CAS  Google Scholar 

  240. Heel, R. C., Brogden, R. N., Speight, T. M., and Avery, G. S., 1979, Atenolol: A review of its pharmacological properties and therapeutic efficacy in hypertension, Drugs 17:425.

    Article  PubMed  CAS  Google Scholar 

  241. Flouvat, B., DeCourt, S., Aubert, P., Potaux, L., Domart, M., Goupil, A., and Baglin, A., 1980, Pharmacokinetics of atenolol in patients with terminal renal failure and the influence of dialysis, Br. J. Clin. Pharm. 9:379.

    CAS  Google Scholar 

  242. Bauer, J. H. and Brooks, C. S., 1979, The long term effect of propranolol therapy on renal function, Am. J. Med. 66:405.

    Article  PubMed  CAS  Google Scholar 

  243. DeLeeuw, P. W. and Birkenhager, W. H., 1982, Renal response to propranolol treatment in hypertensive humans, Hypertension 4:125.

    CAS  Google Scholar 

  244. Wilkinson, R., Stevens, I. M., Pickering, M., Robson, V., Hawkins, T., Kerr, D. N. S., and Harry, J. D., 1980, A study on the effects of atenolol and propranolol on renal function in patients with essential hypertension, Br. J. Clin. Pharmacol. 10:51.

    PubMed  CAS  Google Scholar 

  245. Wainer, E., Boner, G., and Rosenfeld, J. B., 1980, Effects of pindolol on renal function, Clin. Pharmacol. Ther. 28:575.

    Article  PubMed  CAS  Google Scholar 

  246. Roux, A., Aubert, P., Guedon, J., and Flouvat, B., 1980, Pharmacokinetics of acebutolol in patients with all grades of renal failure, Eur. J. Clin. Pharmacol 17:339.

    Article  PubMed  CAS  Google Scholar 

  247. Koch-Weser, J., 1979, Metoprolol, N. Engl. J. Med. 301:698.

    Article  PubMed  CAS  Google Scholar 

  248. Regardh, C. G. and, Johnsson, G., 1980, Clinical pharmacokinetics of metoprolol, Clin. Pharmacokinet. 5:557.

    Article  PubMed  CAS  Google Scholar 

  249. Stone, W. J. and Walle, T., 1980, Massive propranolol metabolite retention during maintenance hemodialysis, Clin. Pharmacol. Ther. 28:449.

    Article  PubMed  CAS  Google Scholar 

  250. Schneck, D. W., Pritchard, J. F., Gibson, T. P., Vary, J. E., and Hayes, A. H., 1980, Effect of dose and uremia on plasma and urine profiles of propranolol metabolites, Clin. Pharmacol. Ther. 27:744.

    Article  PubMed  CAS  Google Scholar 

  251. Chau, P. N., Flouvat, B. L., LeRoux, E., and Safar, M., 1980, Prazosin kinetics in essential hypertension, Clin. Pharmacol. Ther. 28:6.

    Article  PubMed  CAS  Google Scholar 

  252. Lowenthal, D. T., Hobbs, D., Affrime, M. B., Twomey, T. M., Martinez, E. W., and Onesti, G., 1980, Prazosin kinetics and effectiveness in renal failure, Clin. Pharmacol. Ther. 27:779.

    Article  PubMed  CAS  Google Scholar 

  253. Larochelle, P., DuSovich, P., Hamet, P., Laroeque, P., and Armstrong, J., 1982, Prazosin plasma concentration and blood pressure reduction, Hypertension 4:93.

    PubMed  CAS  Google Scholar 

  254. Chaignon, M., LeRoux, E., Aubert, P., Lucsko, M., Safar, M., Flouvat, B., and Guedon, J., 1981, Clinical pharmacology of prazosin in hypertensive patients with chronic renal failure, J. Cardiovasc. Pharmacol. 3:151.

    Article  PubMed  CAS  Google Scholar 

  255. Jaillon, P., 1980, Clinical pharmacokinetics of prazosin, Clin. Pharmacokinet. 5:365.

    Article  PubMed  CAS  Google Scholar 

  256. Lowenthal, D. T. and Affrime, M. B., 1980, Pharmacology and pharmacokinetics of minoxidil, J. Cardiovasc. Pharmacol. 2(Suppl. 2):S93.

    Article  PubMed  Google Scholar 

  257. Bennett, W. M., Golper, T. A., Muther, R. S., and McCarron, D. A., 1980, Efficacy of minoxidil in the treatment of severe hypertension in systemic disorders, J. Cardiovasc. Pharmacol. 2(Suppl. 2):S142.

    Article  PubMed  Google Scholar 

  258. Pettinger, W. A., 1980, Minoxidil and the treatment of severe hypertension, N. Engl. J. Med. 303:922.

    Article  PubMed  CAS  Google Scholar 

  259. Ogilvie, R. I., Nadeau, J. H., and Sitar, D. S., 1982, Diazoxide concentration-response relation in hypertension, Hypertension 4:167.

    PubMed  CAS  Google Scholar 

  260. Marone, C. and Reubi, F. C., 1980, Effects of a new diuretic (piretanide) compared with furosemide on renal diluting and concentrating mechanisms in patients with the nephrotic syndrome, Eur. J. Clin. Pharmacol. 17:165.

    Article  PubMed  CAS  Google Scholar 

  261. Elliott, H. L., Ansari, A. F., Campbell, B. C., and Lawrence, J. R., 1982, Protein binding of piretanide in normal and uremic serum, Eur. J. Clin. Pharmacol. 21:311.

    Article  PubMed  CAS  Google Scholar 

  262. Brazier, J. L., Pozet, N., Faucon, G., Traeger, J., and Hadj-Haissa, A., 1982, Kinetics of a high dose of piretanide in renal failure, Eur. J. Clin. Pharmacol. 21:307.

    Article  PubMed  CAS  Google Scholar 

  263. Riva, E., Fossali, E., and Bettinelli, A., 1982, Kinetics of furosemide in children with chronic renal failure undergoing regular hemodialysis, Eur. J. Clin. Pharmacol. 21:303.

    Article  PubMed  CAS  Google Scholar 

  264. Cohen, M., 1981, Pharmacology of bumetanide, J. Clin. Pharmacol. 21:537.

    PubMed  CAS  Google Scholar 

  265. Schwartz, M. A., 1981, Metabolism of bumetanide, J. Clin. Pharmacol. 21:555.

    PubMed  CAS  Google Scholar 

  266. Smith, D. E., Gambertoglio, J., Vincenti, F., and Benet, L., 1981, Furosemide kinetics and dynamics after kidney transplant, Clin. Pharmacol. Ther. 30:105.

    Article  PubMed  Google Scholar 

  267. Odlind, B. G., and Beermann, B., 1980, Diuretic resistance: Reduced bioavailability and effect of oral furosemide, Br. Med. J. 1:1577.

    Article  Google Scholar 

  268. Anonymous, 1981, Amiloride—A potassium sparing diuretic, Med. Lett. 23:109.

    Google Scholar 

  269. George, C. F., 1980, Amiloride handing in renal failure, Br. J. Clin. Pharmacol. 9:94.

    PubMed  CAS  Google Scholar 

  270. Chrysant, S. and Luu, T. M., 1980, Effects of amiloride on arterial pressure and renal function, J. Clin. Pharmacol. 20:332.

    Article  PubMed  CAS  Google Scholar 

  271. Bailey, R. R., Lynn, K. L., Drennan, C. J., and Turner, G. A. L., 1982, Triamterene-induced acute interstitial nephritis, Lancet 1:226.

    Article  PubMed  CAS  Google Scholar 

  272. Ettinger, B., Oldroyd, N. O., and Sorgel, F., 1980, Triamterene nephrolithiasis, JAMA 244:2443.

    Article  PubMed  CAS  Google Scholar 

  273. Fawaz-Estrup, F. and Ho, G., 1981, Reversible acute renal failure induced by indomethacin, Arch. Intern. Med. 141:1670.

    Article  PubMed  CAS  Google Scholar 

  274. Muther, R. S., Potter, R. M., and Bennett, W. M., 1981, Aspirin-induced depression of glomerular filtration rate: Role of sodium balance, Ann. Intern. Med. 94:317.

    PubMed  CAS  Google Scholar 

  275. Kleinknecht, C., Broyer, M., Gulbler, M. D., and Palcoux, J., 1980, Irreversible renal failure after indomethacin in steroid-resistant nephrosis, N. Engl. J. Med. 302:691.

    PubMed  CAS  Google Scholar 

  276. Finkelstein, A., Fraley, D. S., Stachura, I., Feldman, H. A., Gandy, D. R., and Bourke, E., 1982, Fenoprofen nephropathy: Lipoid nephrosis and interstitial nephritis, Am. J. Med. 72:81.

    Article  PubMed  CAS  Google Scholar 

  277. Stafanger, G., Larsen, H. W., Hansen, H., and Sorensen, K., 1981, Pharmacokinetics of ketoprofen in patients with chronic renal failure, Scand. J. Rheum. 10:189.

    CAS  Google Scholar 

  278. Anttila, M., Haataja, M., and Kasanen, A., 1980, Pharmacokinetics of naproxen in subjects with normal and impaired renal function, Eur. J. Clin. Pharm. 18:263.

    Article  CAS  Google Scholar 

  279. Kampmann, J. P. and Hansen, J. M., 1981, Clinical pharmacokinetics of antithyroid drugs, Clin. Pharmacokinet. 6:401.

    Article  PubMed  CAS  Google Scholar 

  280. Balant, L., 1981, Clinical pharmacokinetics of sulfonylurea hypoglycemic drugs, Clin. Pharmacokinet. 6:215.

    Article  PubMed  CAS  Google Scholar 

  281. Juma, F. D., Rogers, H. J., and Trounce, J. R., 1981, Effect of renal insufficiency on the pharmacokinetics of cyclophosphamide and some of its metabolites, Eur. J. Clin. Pharm. 19:443.

    Article  CAS  Google Scholar 

  282. Ramzan, M. J., Somogyi, A. A., Walker, J. S., Shanks, C. A., and Triggs, E. J., 1981, Clinical pharmacokinetics of the nondepolarizing muscle relaxants, Clin. Pharmacokinet. 6:25.

    Article  PubMed  CAS  Google Scholar 

  283. Estes, J. W., 1980, Clinical pharmacokinetics of heparin, Clin. Pharmacol. 5:204.

    Article  CAS  Google Scholar 

  284. Sherrard, D. J., Goldberg, A. B., Haas, L. B., and Brunzell, J. D., 1980, Chronic Clofibrate therapy in maintenance hemodialysis patients, Nephron 25:219.

    Article  PubMed  CAS  Google Scholar 

  285. Klintmalm, G. B., Iwatsuki, S., and Starzl, T. E., 1981, Nephrotoxicity of cyclosporin A in liver and kidney transplant recipients, Lancet 1:470.

    Article  PubMed  CAS  Google Scholar 

  286. Shulman, H., Striker, G., Deeg, H. J., Kennedy, M., Storb, R., and Thomas, E. D., 1981, Nephrotoxicity of cyclosporin A after allogeneic marrow transplantation, N. Engl. J. Med. 305:1392.

    Article  PubMed  CAS  Google Scholar 

  287. Hestbach, J., Hansen, H. E., Amsden, A., and Olsen, S., 1977, Chronic renal lesions following long term treatment with lithium, Kidney Int. 12:205.

    Article  Google Scholar 

  288. Aurell, M., Svalander, C., Wallin, L., and Alling, C., 1981, Renal function and biopsy findings in patients on long-term lithium treatment, Kidney Int. 20:663.

    Article  PubMed  CAS  Google Scholar 

  289. Walker, R., Bennett, W. M., Davies, B., and Kincaid-Smith, P., 1982, Structural and functional effects of long-term lithium therapy, Kidney Int. 21:513.

    Article  Google Scholar 

  290. Blachley, J. D. and Hill, J. B., 1981, Renal and electrolyte disturbances associated with cis-platinum, Ann. Intern. Med. 95:628.

    PubMed  CAS  Google Scholar 

  291. Bennett, W. M., 1981, Antibiotic induced acute renal failure, Semin. Nephrol. 1:43.

    CAS  Google Scholar 

  292. Bennett, W. M., 1981, Aminoglycoside nephrotoxicity, Miner. Electrol. Metab. 6:277.

    CAS  Google Scholar 

  293. Chronin, R. E., 1979, Aminoglycoside nephrotoxicity pathogenesis and prevention, Clin. Nephrol. 11:251.

    Google Scholar 

  294. Russo, J. and Adelman, R. D., 1980, Gentamicin-induced Fanconi syndrome, J. Pediat. 96:151.

    Article  PubMed  CAS  Google Scholar 

  295. Kelnar, C. J., Taor, W. S., Reynolds, D. J., Smith, D. R., Slavin, B. M., and Brook, C. G., 1978, Hypomagnesemic hypocalcemia with hypokalemia caused by treatment with high dose gentamicin, Arch. Dis. Child. 53:817.

    Article  PubMed  CAS  Google Scholar 

  296. Bennett, W. M., Gilbert, D. N., Houghton, D. C., and Porter, G. A., 1974, Gentamicin nephrotoxicity: Morphologic and pharmacologic features, West. J. Med. 126:65.

    Google Scholar 

  297. Houghton, D. C., Campbell-Boswell, M., Bennett, W. M., Porter, G. A., and Brooks, R. E., 1978, Myeloid bodies in the renal tubules of humans: Relationship to gentamicin therapy, Clin. Nephrol. 10:140.

    PubMed  CAS  Google Scholar 

  298. Schentag, J. J. and, Jusko, W. J., 1977, Renal clearance and tissue accumulation of gentamicin, Clin. Pharmacol. Ther. 22:364.

    PubMed  CAS  Google Scholar 

  299. Pastoriza-Munoz, F., Bowman, R. L., and Kaloyanides, G. J., 1979, Renal tubular transport of gentamicin in the rat, Kidney Int. 16:440.

    Article  PubMed  CAS  Google Scholar 

  300. Silverblatt, F. J. and Kuehn, C., 1979, Autoradiography of gentamicin uptake by the rat proximal tubular cell, Kidney Int. 15:335.

    Article  PubMed  CAS  Google Scholar 

  301. Just, M. and Habermann, E., 1977, The renal handling of polybasic drugs, Arch. Pharmacol. 300:57.

    Article  CAS  Google Scholar 

  302. Collier, V. V., Leitman, P. S., and Mitch, W. E., 1979, Evidence for luminal uptake of gentamicin in perfused rat kidney, J. Pharmacol. Exp. Ther. 210:247.

    PubMed  CAS  Google Scholar 

  303. Tulkens, G. A., Van Hoof, F., and Tulkens, P., 1979, Gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts, Lab. Invest. 40:481.

    PubMed  Google Scholar 

  304. Weinberg, J. M. and Humes, H. D., 1980, Mechanisms of gentamicin induced dysfunction of renal cortical mitochondria, Arch. Biochem. Biophys. 205:222.

    Article  PubMed  CAS  Google Scholar 

  305. Simmons, C. F., Bogusky, R. T., and Humes, H. D., 1980, Inhibitory effects of gentamicin on renal oxidative phosphorylation, J. Pharmacol. Exp. Ther. 214:709.

    PubMed  CAS  Google Scholar 

  306. Cronin, R., Nix, K., Ferguson, E., and Henrich, W., 1980, Changes in renal cortical electrolyte content and Na-K-ATPase activity in early gentamicin nephrotoxicity, Clin. Res. 28:843A.

    Google Scholar 

  307. Williams, P. D., Holohan, P. D., and Ross, C. R., 1981, Gentamicin nephrotoxicity: Acute biochemical correlates in rats, Toxicol. Appl. Pharmacol. 61:234.

    Article  PubMed  CAS  Google Scholar 

  308. Elliott, W. C., Gilbert, D. N., DeFehr, J., Bennett, W. M., and McCarron, D. A., 1982, Protection from experimental gentamicin toxicity by dietary calcium loading, Kidney Int. 21:217.

    Google Scholar 

  309. Bennett, W. M., Hartnett, M. N., Gilbert, D. N., Houghton, D. C., and Porter, G. A., 1976, Effect of sodium intake on gentamicin nephrotoxicity in the rat, Proc. Soc. Exp. Biol. Med. 146:894.

    Google Scholar 

  310. Adams, H. R. and Durrett, L. R., 1978, Gentamicin blockade of slow Ca+ + channels in atrial myocardium of guinea pigs, J. Clin. Invest. 62:241.

    Article  PubMed  CAS  Google Scholar 

  311. Harkonen, S. and Kjellstrand, C., 1981, Contrast nephropathy, Am. J. Nephrol. 1:69.

    Article  PubMed  CAS  Google Scholar 

  312. Eisenberg, R. L., Bank, W. O., and Hedgcock, M. W., 1980, Renal failure after major angiography, Am. J. Med. 68:43.

    Article  PubMed  CAS  Google Scholar 

  313. Eisenberg, R. L., Bank, W. O., and Hedgcock, M. W., 1981, Renal failure after major angiography, Am. J. Radiol. 136:859.

    CAS  Google Scholar 

  314. Fang, L. S., Sirota, R. A., Eben, T. H., and Lichtenstein, N. S., 1980, Low fractional excretion of sodium with contrast media-induced acute renal failure, Arch. Intern. Med. 140:531.

    Article  PubMed  CAS  Google Scholar 

  315. Bennett, W. M., Luft, F. C., and Porter, G. A., 1980, Pathogenesis of renal failure due to aminoglycosides and radiographic contrast media, Am. J. Med. 69:767.

    Article  PubMed  CAS  Google Scholar 

  316. Forrest, J. B., Howards, S. S., and Gillenwater, J. Y., 1981, Osmotic effects of intravenous contrast agents on renal function, J. Urol. 125:147.

    PubMed  CAS  Google Scholar 

  317. Ainto, H. R., Chou, S., Ponush, J. G., and Shapiro, W. B., 1981, Infusion intravenous pyelography and renal function, Arch. Intern. Med. 141:1652.

    Article  Google Scholar 

  318. Rudnick, M. R., Basti, C., Elfenbein, I. B., Sirota, R. A., Yudis, M., and Narins, R. G., 1982, Cimetidine-induced acute renal failure, Ann. Intern. Med. 96:180.

    PubMed  CAS  Google Scholar 

  319. Richman, A. V., Narayan, J. L., and Hirschfield, J. S., 1981, Acute interstitial nephritis and acute renal failure associated with Cimetidine therapy, Am. J. Med. 70:1272.

    Article  PubMed  CAS  Google Scholar 

  320. Blohme, I. and, Johansson, S., 1981, Renal pelvic neoplasms and atypical urothelium in patients with end-stage analgesic nephropathy, Kidney Int. 20:671.

    Article  PubMed  CAS  Google Scholar 

  321. Gonwa, T. A., Corbett, W. T., Schey, H., and Buckalew, V. M., 1980, Analgesic-associated nephropathy and transitional cell carcinoma of the urinary tract, Ann. Intern. Med. 93:249.

    PubMed  CAS  Google Scholar 

  322. Gonwa, T. A., Hamilton, R. W., and Buckalew, V. M., 1981, Chronic renal failure and end stage renal disease in northwest North Carolina: Importance of analgesic-associated nephropathy, Arch. Intern. Med. 141:462.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Nephrology, University of Oregon Health Sciences Center, Portland, Oregon, 97201, USA

    William M. Bennett

Authors
  1. William M. Bennett
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Washington University School of Medicine, St. Louis, Missouri, USA

    Saulo Klahr M. D.

  2. University of Southern California School of Medicine, Los Angeles, California, USA

    Shaul G. Massry M. D.

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Plenum Publishing Corporation

About this chapter

Cite this chapter

Bennett, W.M. (1983). Drugs and the Kidney. In: Klahr, S., Massry, S.G. (eds) Contemporary Nephrology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6722-6_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-6722-6_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6724-0

  • Online ISBN: 978-1-4615-6722-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation