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Peptic Ulcer Disease

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Part of the book series: Contemporary Internal Medicine ((COIM,volume 1))

Abstract

A 51-year-old man was admitted to University Hospital in August 1986 with a three-day history of intractable nausea and vomiting, moderate epigastric pain, and blood-streaked emesis on the day of admission. He had become progressively weak, lightheaded, and faint when standing, and was unable to retain medication or liquids at home. His prior history was relevant for emergency ulcer surgery nineteen years previously, believed to be for perforation. Details of the operation were not known to the patient and records were not immediately available. Since then, he had experienced episodic pain, nausea and vomiting for a few days every year or so. These symptoms were usually relieved by fasting and antacids. He had sought little formal medical care but periodically received a prescription for Cimetidine from a public clinic and used it for indigestion, pain, or emesis. Past history was otherwise not remarkable. Family history included peptic ulcer disease in the father; no details were known to the patient. The patient worked part-time parking cars, was married, and smoked two packs of cigarettes daily. He denied past or present alcohol or drug abuse, or use of any other medication.

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References

  1. Feldman M, Richardson CT. Total 24-hour gastric acid secretion in patients with duodenal ulcer. Gastroenterology 1986;90:540–4.

    PubMed  CAS  Google Scholar 

  2. Quigley EMM, Turnberg LA. pH of the microclimate lining human gastric and duodenal mucosa in vivo. Gastroenterology 1987;92:1876–84.

    PubMed  CAS  Google Scholar 

  3. Ahlquist DA, Dozois RR, Zinsmeister AR, Malagelada J-R. Duodenal prostaglandin synthesis and acid load in health and in duodenal ulcer disease. Gastroenterology 1983;85:522–8.

    PubMed  CAS  Google Scholar 

  4. Isenberg JI, Selling JA, Hogan DL, Koss MA. Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. N Engl J Med 1987;316:374–9.

    Article  PubMed  CAS  Google Scholar 

  5. Sontag S, Graham DY, Belsito A, et al. Cimetidine, cigarette smoking, and recurrence of duodenal ulcer. N Engl J Med 1984;311:689–93.

    Article  PubMed  CAS  Google Scholar 

  6. Boyd EJS, Wilson JA, Wormsley KG. Smoking impairs therapeutic gastric inhibition. Lancet 1983;I:95–7.

    Article  Google Scholar 

  7. Quimby GF, Bonnice CA, Burstein SH, Eastwood GL. Active smoking depresses prostaglandin synthesis in human gastric mucosa. Ann Intern Med 1986;104:616–9.

    PubMed  CAS  Google Scholar 

  8. Blaser MJ. Gastric campylobacter-like organisms, gastritis, and peptic ulcer disease. Gastroenterology 1987;93:371–83.

    PubMed  CAS  Google Scholar 

  9. Dooley CP, Cohen H. The clinical significance of Campylobacter pylori. Ann Intern Med 1988;108:70–9.

    PubMed  CAS  Google Scholar 

  10. Horrocks JC, DeDombal FT. Clinical presentation of patients with “dyspepsia”. Gut 1978;19:19–26.

    Article  PubMed  CAS  Google Scholar 

  11. Priebe WM, DaCosta LR, Beck IT. Is epigastric tenderness a sign of peptic ulcer disease? Gastroenterology 1982;82:16–9.

    PubMed  CAS  Google Scholar 

  12. Dooley CP, Lawson AW, Stace NH, et al. Double-contrast barium meal and upper gastrointestinal endoscopy. Ann Intern Med 1984;101:53845.

    Google Scholar 

  13. Kahn K, Greenfield S. Endoscopy in the evaluation of dyspepsia. Ann Intern Med 1985;102:266–9.

    Google Scholar 

  14. Nyren O, Adami H-O, Bates S, et al. Absence of therapeutic benefit from antacids or Cimetidine in non-ulcer dyspepsia. N Engl J Med 1986;314:339–43.

    Article  PubMed  CAS  Google Scholar 

  15. Rauws EAJ, Langenberg W, Houthoff HJ, Zanen HC, Tytgat GNJ. Campylobacter pyloridis-associated chronic active antral gastritis. Gastroenterology 1988;94:33–40.

    PubMed  CAS  Google Scholar 

  16. Holdstock G, Harman M, Machin D, Patel C, Lloyd RS. Prospective testing of a scoring system designed to improve case selection for upper gastrointestinal investigation. Gastroenterology 1986;90:1164–9.

    PubMed  CAS  Google Scholar 

  17. Peterson W, Sturdevant RAL, Frankel HD, et al. Healing of duodenal ulcer with an antacid regimen. N Engl J Med 1977;297:341–5.

    Article  PubMed  CAS  Google Scholar 

  18. Martin F, Farley A, Gagnon M, Bensemana D. Comparison of the healing capacities of sucralfate and Cimetidine in the short-term treatment of duodenal ulcer: a double-blind randomized trial. Gastroenterology 1982;82:401–5.

    PubMed  CAS  Google Scholar 

  19. McCullough AJ. A multicenter, randomized, double-blind study comparing famotidine with ranitidine in the treatment of active duodenal ulcer disease. Amer J Med 1986;81 (suppl4B):17–24.

    Google Scholar 

  20. Weberg R, Berstad A, Lange O, et al. Duodenal ulcer healing with four antacid tablets daily. Scand J Gastroenterol 1985;20:1041–5.

    Article  PubMed  CAS  Google Scholar 

  21. Freston JW. Cimetidine. Ann Intern Med 1982;97:573–80, 728–34.

    PubMed  CAS  Google Scholar 

  22. Zeldis JB, Friedman LS, Isselbacher KJ. Ranitidine: a new H2-receptor antagonist. N Engl J Med 1983; 309:1368–73.

    Article  PubMed  CAS  Google Scholar 

  23. Strumm WB. Prevention of duodenal ulcer recurrence. Ann Intern Med 1986;105:757–61.

    Google Scholar 

  24. Tarnawski A, Hollander D, Krause WJ, Zipser RD, Stachura J, Gergely H. Does sucralfate affect the normal gastric mucosa? Histological, ultrastructural, and functional assessment in the rat. Gastroenterology 1986;90:893–905.

    PubMed  CAS  Google Scholar 

  25. Lam SK, Hui WM, Lau WY, et al. Sucralfate overcomes the adverse effect of cigarette smoking on duodenal ulcer healing and prolongs subsequent remission. Gastroenterology 1987;92:1193–1201.

    PubMed  CAS  Google Scholar 

  26. Hawkey CJ, Walt RP. Prostaglandins for peptic ulcer, a promise unfulfilled. Lancet 1986;II:1084–7.

    Article  Google Scholar 

  27. Lauritsen K, Rune SJ, Bytzer P, et al. Effect of omeprazole and Cimetidine on duodenal ulcer. N Engl J Med 1985;312:958–61.

    Article  PubMed  CAS  Google Scholar 

  28. Hassan M, Sircus W. The factors determining success or failure of Cimetidine treatment of peptic ulcer. J Clin Gastroenterol 1981;3:225–9.

    Article  Google Scholar 

  29. Silvis SE. Final report on the United States multicenter trial comparing ranitidine to Cimetidine as maintenance therapy following healing of duodenal ulcer. J Clin Gastroenterol 1985;7:482–7.

    Article  PubMed  CAS  Google Scholar 

  30. Masoero G, Rocchia F, Rossanino A, Marchetto M, Benitti V, DelaPierre M. Comparison of ranitidine and sucralfate in the long-term treatment of duodenal ulcer. J Clin Gastroenterol 1986;8:624–7.

    Article  PubMed  CAS  Google Scholar 

  31. Prichard PJ, Jones DB, Yeomans ND, Mihaly GW, Smallwood RA, Louis WJ. The effectiveness of ranitidine in reducing gastric acid-secretion decreases with continued therapy. Br J Clin Pharmacol 1986;22:663–8.

    PubMed  CAS  Google Scholar 

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© 1988 Plenum Publishing Corporation

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Caldwell, J.H. (1988). Peptic Ulcer Disease. In: Bowen, J., Mazzaferri, E.L. (eds) Contemporary Internal Medicine. Contemporary Internal Medicine, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6713-4_15

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  • DOI: https://doi.org/10.1007/978-1-4615-6713-4_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6715-8

  • Online ISBN: 978-1-4615-6713-4

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