Abstract
The possibility has been suggested that prolactin may interact with adrenal hormones to affect renal function in addition to the evidence indicating a direct effect on the kidney. Burstyn, Horrobin, and Manku (1972) and Horrobin, Manku, and Burstyn (1973) have shown that aldosterone can induce a natriuresis in the presence of excess salt intake or excess Cortisol and that this natriuresis can be reversed by prolactin injection. Moreover, Relkin and Adachi (1973) have suggested that prolactin is necessary for the enhanced aldosterone secretion rates observed in sodium-deprived rats. These studies indicated that prolactin must be present, at least under certain conditions, in order for aldosterone to induce an antinatriuretic effect. Whether aldosterone is necessary for prolactin to affect kidney function is not known. An experiment was designed, therefore, to determine if the adrenals, i.e. aldosterone, must be present for the renal effects of prolactin to occur.
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References
Burstyn, P.G., Horrobin, D.F., and Manku, M.S. (1972). Saluretic action of aldosterone in the presence of increased salt intake and restoration of normal action by prolactin or by oxytocin. J. Endocrinol. 55, 369–376.
Horrobin, D.F., Manku, M.S., and Burstyn, P.G. (1973). Saluretic action of aldosterone in the presence of excess Cortisol: Restoration of salt-retaining action of prolactin. J. Endocrinol. 56, 343–344.
Relkin, R., and Adachi, M. (1973). Effects of sodium deprivation on pituitary and plasma prolactin, growth hormone, and thyrotropin levels in the rat. Neuroendocrinology 11, 240–247.
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© 1977 Plenum Press, New York
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Pasley, J.N., Bond, G.C., Koike, T.I., Llerena, L. (1977). The Effect of Adrenalectomy on the Renal Response to Intravenous Prolactin. In: Dellmann, HD., Johnson, J.A., Klachko, D.M. (eds) Comparative Endocrinology of Prolactin. Advances in Experimental Medicine and Biology, vol 80. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6675-5_9
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DOI: https://doi.org/10.1007/978-1-4615-6675-5_9
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