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The Role of Prolactin in Mammogenesis and Lactogenesis

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Comparative Endocrinology of Prolactin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 80))

Abstract

Although a great deal of new information about the physiologic and pathologic regulation of prolactin secretion in man has become available in recent years, precise delineation of the role of prolactin in human mammogenesis and lactogenesis has been difficult. This should not be surprising in light of the fact that its role in these processes is imperfectly understood in sub-primate mammals. Though detailed information has been accumulated on hormonal requirements for the maintenance and function of mammary expiants in short-term tissue culture in vitro, the relevance of these observations to in vivo lactational physiology remains unclear. A substantial body of literature dealing with lactation and its vascular cytologic, biochemical, and physiologic aspects has been developed during the past 30 years, but many aspects of breast function remain poorly understood (Larson and Smith, 1974).

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References

  • Ben-Jonathan, N., Oliver, C., and Mical, R.S. (1976). Dopamine secretion into hypophysial portal blood during the estrus cycle and pregnancy in the rat. Program, 58th Meeting, Endocrine Society, Abstract 269, Endocrinology 98, Supplement, p. 191.

    Google Scholar 

  • Birge, C.A., Jacobs, L.S., Hammer, C.T., and Daughaday, W.H. (1970). Catecholamine inhibition of prolactin secretion by isolated rat adenohypophyses. Endocrinology 86, 120–130.

    Article  PubMed  CAS  Google Scholar 

  • Bowers, C.Y., Friesen, H.G., Hwang, P., Guyda, H.J., and Folkers, K. (1971). Prolactin and thyrotropin release in man by synthetic pyroglutamyl-histidyl-prolinamide. Biochem. Biophys. Res. Commun. 45, 1033–1041.

    Article  PubMed  CAS  Google Scholar 

  • Carlson, H.E., Jacobs, L.S., and Daughaday, W.H. (1973). Growth hormone, thyrotropin and prolactin responses to thyrotropin-releasing hormone following diethylstilbestrol pretreatment. J. Clin. Endocrinol. Metab. 37, 488–490.

    Article  PubMed  CAS  Google Scholar 

  • Ceriani, R.L. (1970) Fetal mammary gland differentiation in vitro in response to hormones. I. Morphological findings. Devel-opm. Biol. 21, 506–529.

    Article  CAS  Google Scholar 

  • Daughaday, W.H. and Jacobs, L.S. (1972). Normal and pathologic secretion of prolactin in man. In: Endocrinology, Proceedings IV International Congress of Endocrinology (Scow, R.O., ed.), pp. 622–628, Excerpta Medica International Congress Series No. 273.

    Google Scholar 

  • del Pozo, E., Varga, L., Wyss, H., Tolis, G., Friesen, H., Wenner, R., Vetter, L., and Uettwiler, A. (1974). Clinical and hormonal response to bromocriptin (CB-154) in the galactorrhea syndromes. J. Clin. Endocrinol. Metab. 39, 18–36.

    Article  PubMed  Google Scholar 

  • Ehara, Y., Yen, S.S.C, and Siler, T.M. (1975). Serum prolactin levels during puberty. Amer. J. Obstet. Gynec. 121, 995–997.

    PubMed  CAS  Google Scholar 

  • Foley, T.P. Jr., Jacobs, L.S., Hoffman, W., Daughaday, W.H., and Blizzard, R.M. (1972). Human prolactin and thyrotropin concentrations in the serums of normal and hypopituitary children before and after the administration of synthetic thyrotropin-releasing hormone. J. Clin. Invest. 51, 2143–2150.

    Article  PubMed  Google Scholar 

  • Frantz, A.G., Kleinberg, D.L., and Noel, G.L. (1972). Studies on prolactin in man. Rec. Prog. Horm. Res. 28, 527–590.

    PubMed  CAS  Google Scholar 

  • Friesen, H.G., Belanger, C., Guyda, H.J., and Hwang, P. (1972). The synthesis and secretion of placental lactogen and pituitary prolactin. In: Lactogenic Hormones (Wolstenholme, G.F. W. and Knight, J., eds.), pp. 83–103, Churchill-Livingstone, London.

    Google Scholar 

  • Fuxe, K. (1964). Cellular localization of monoamines in the median eminence and the infundibular stem of some mammals. Z. Zell-forsch Mikrosk. Anat. 61, 710–724.

    Article  CAS  Google Scholar 

  • Gautvik, K.M., Tashjian, A.H. Jr., Kourides, I.A., Weintraub, B.D., Graeber, C.T., Maloof, F., Suzuki, K., and Zuckerman, J.E. (1974). Thyrotropin-releasing hormone is not the sole physiologic mediator of prolactin release during suckling. New Engl. J. Med. 290, 1162–1165.

    Article  PubMed  CAS  Google Scholar 

  • Hwang, P., Guyda, H., and Friesen, H. (1971). A radioimmunossay for human prolactin. Proc. Natl. Acad. Sci. 68, 1902–1906.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs, L.S. and Daughaday, W.H. (1973). Pathophysiology and control of prolactin secretion in patients with pituitary and hypothalamic disease. In: Human Prolactin (Pasteeis, J.L. and Robyn, C., eds.), pp. 189, International Congress Series No. 308, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Jacobs, L.S., Mariz, I.K., and Daughaday, W.H. (1972). A mixed heterologous radioimmunoassay for human prolactin. J. Clin. Endocrinol. Metab. 34, 484–490.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs, L.S., Snyder, P.J., Wilber, J.F., Utiger, R.D., and Daughaday, W.H. (1971). Increased serum prolactin after administration of synthetic thyrotropin releasing hormone (TRH) in man. J. Clin. Endocrinol. Metab. 33, 996–999.

    Article  PubMed  CAS  Google Scholar 

  • Kolodny, R.C., Jacobs, L.S., and Daughaday, W.A. (1972). Mammary stimulation causes prolactin secretion in non-lactating women. Nature 238, 284–286.

    Article  PubMed  CAS  Google Scholar 

  • Larson, B.L. and Smith, V.R., eds. (1974). Lactation/A Comprehensive Treatise, 3 volumes, Academic Press. Volume 1: The Mammary Gland/Development and Maintenance, Volume 2: Biosynthesis and Secretion of Milk/Bis eases, and Volume 3: Nutrition and Biochemistry of Milk/Maintenance of Lactation.

    Google Scholar 

  • Lu, K.H. and Meites, J. (1973). Effects of serotonin precursors and melatonin on serum prolactin release in rats. Endocrinology 93, 152–155.

    Article  PubMed  CAS  Google Scholar 

  • Machlin, L.J., Jacobs, L.S., Cirulis, N., Kimes, R., and Miller, R. (1974). An assay for growth hormone and prolactin-releasing activities using a bovine pituitary cell culture system. Endocrinology 95, 1350–1358.

    Article  PubMed  CAS  Google Scholar 

  • Maclndoe, J.H. and Turkington, R.W. (1973). Stimulation of human prolactin secretion by intravenous infusion of L-tryptophan. J. Clin. Invest. 52, 1972–1978.

    Article  Google Scholar 

  • Macleod, R.M. and Lehmeyer, J.E. (1974). Studies on the mechanisms of the dopamine-mediated inhibition of prolactin secretion. Endocrinology 94, 1077–1085.

    Article  PubMed  CAS  Google Scholar 

  • Malarkey, W.B. (1975). Nonpuerperal lactation and normal prolactin regulation. J. Clin. Endocrinol. Metab. 40, 198–204.

    Article  PubMed  CAS  Google Scholar 

  • McMurtry, J.P. and Malven, P.V. (1974a). Radioimmunoassay of endogenous and exogenous prolactin in milk of rats. J. Endocrinol. 61, 211–217.

    Article  PubMed  CAS  Google Scholar 

  • McMurtry, J.P. and Malven, P.V. (1974b). Experimental alterations of prolactin levels in goat milk and blood plasma. Endocrinology 95, 559–564.

    Article  PubMed  CAS  Google Scholar 

  • Meites, J. and Nicoll, C.S. (1966). Adenohypophysis: Prolactin. Ann. Rev. Physiol. 28, 57–88.

    Article  CAS  Google Scholar 

  • Nandi, S. and Bern, H.A. (1961). The hormone responsible for lac-togenesis in BALB-cCrgl mice. Gen. Comp. Endocrinol. 1, 195–210.

    Article  PubMed  CAS  Google Scholar 

  • Nicoll, C.S., Fiorindo, R.P., McKennee, C.R., and Parsons, J.A. (1970). Assay of hypothalamic factors which regulate prolactin secretion. In: Hypophysiotropic Hormones of the Hypothalamus: Assay and Chemistry (Meites, J., ed.), pp. 115–144, Williams and Wilkins, Baltimore.

    Google Scholar 

  • Noel, G.L., Suh, H.K., and Frantz, A.G. (1974). Prolactin release during nursing and breast stimulation in postpartum and non-postpartum subjects. J. Clin. Endocrinol. Metab. 38, 413–423.

    Article  PubMed  CAS  Google Scholar 

  • Posner, B.I. and Bergeron, J.J.M. (1976). Intracellular polypeptide hormone receptors. Program, 58th Meeting, Endocrine Society, Abstract 218, Endocrinology 98, Supplement, pp. 165.

    Google Scholar 

  • Rimoin, D.L., Holzman, G.B., Merimee, T.J., Rabinowitz, D., Barnes, A.C., Tyson, J.E., and McKusick, V.A. (1968). Lactation in the absence of human growth hormone. J. Clin. Endocrinol. Metab. 28, 1183–1188.

    Article  PubMed  CAS  Google Scholar 

  • Shaar, C.J. and Clemens, J.A. (1974). The role of catecholamines in the release of anterior pituitary prolactin in vitro. Endocrinology 95, 1201–1212.

    Article  Google Scholar 

  • Snyder, P.J., Jacobs, L.S., Utiger, R.D., and Daughaday, W.H. (1973). Thyroid hormone inhibition of the prolactin response to thyro-tropin-releasing hormone. J. Clin. Invest. 52, 2324–2329.

    Article  PubMed  CAS  Google Scholar 

  • Snyder, P.J., Jacobs, L.S., Rabello, M.M., Sterling, F.H., Shore, R.N., Utiger, R.D., and Daughaday, W.H. (1974). Diagnostic value of thyrotropin-releasing hormone in pituitary and hypothalamic diseases: Assessment of thyrotropin and prolactin secretion in 100 patients. Annals Int. Med. 81, 751–757.

    CAS  Google Scholar 

  • Turkington, R.W. (1972). Phenothiazine stimulation test for prolactin reserve: The syndrome of isolated prolactin deficiency. J. Clin. Endocrinol. Metab. 34, 247–250.

    Article  Google Scholar 

  • Tyson, J.E., Hwang, P., Guyda, H., and Friesen, H.G. (1972). Studies of prolactin secretion in human pregnancy. Amer. J. Obstet. Gynecol. 113, 14–20.

    CAS  Google Scholar 

  • Tyson, J.E., Khojandi, M., Huth, J., and Andreasson, B. (1975). The influence of prolactin secretion on human lactation. J. Clin. Endocrinol. Metab. 40, 764–773.

    Article  PubMed  CAS  Google Scholar 

  • Valverde, C., and Chieffo, V. (1971). Prolactin releasing factors in porcine hypothalamic extracts. Program, 53rd Meeting, Endocrine Society, Abstract 83, Endocrinology 88, Supplement, p. A84.

    Google Scholar 

  • Woolf, P.D., Jacobs, L.S., Donofrio, R., Burday, S.Z., and Schalch, D.S. (1974). Secondary hypopituitarism: Evidence for continuing regulation of hormone release. J. Clin. Endocrinol. Metab. 38, 71–76.

    Article  PubMed  CAS  Google Scholar 

  • Yen, S.S.C., Ehara, Y., and Siler, T.M. (1974). Augmentation of prolactin secretion by estrogen in hypogonadal women. J. Clin. Invest. 53, 652–655.

    Article  PubMed  CAS  Google Scholar 

Discussion References

  • Ehara, Y., Siler, T., Vandenberg, G., Sinha, Y.M., and Yen, S.S.C. (1973). Circulating prolactin levels during the menstrual cycle: Episodic release and diurnal variation. Amer. J. Obstet. Gynec. 117, 962–970.

    PubMed  CAS  Google Scholar 

  • Friesen, H.G. (1973). In Human Prolactin (Pasteels, J.L. and Robyn, C., eds.), ICS #308, Excerpta Medica, Amsterdam.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Medicine-Metabolism, Washington University School of Medicine, 660 S. Euclid, St. Louis, Missouri, 63110, USA

    Laurence S. Jacobs

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  1. Laurence S. Jacobs
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Editor information

Editors and Affiliations

  1. Iowa State University, Ames, Iowa, USA

    Horst-Dieter Dellmann

  2. University of Missouri, Columbia, Missouri, USA

    J. Alan Johnson  & David M. Klachko  & 

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© 1977 Plenum Press, New York

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Jacobs, L.S. (1977). The Role of Prolactin in Mammogenesis and Lactogenesis. In: Dellmann, HD., Johnson, J.A., Klachko, D.M. (eds) Comparative Endocrinology of Prolactin. Advances in Experimental Medicine and Biology, vol 80. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6675-5_7

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  • DOI: https://doi.org/10.1007/978-1-4615-6675-5_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6677-9

  • Online ISBN: 978-1-4615-6675-5

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