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Historical Perspectives of Lactogenic Hormone (Prolactin) a Summary of My Research at the University of Missouri

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Book cover Comparative Endocrinology of Prolactin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 80))

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Abstract

In 1927 when I began my research at the University of Missouri, I became interested in the hormonal stimulation of the mammary gland. Early studies (Turner and Frank, 1930a, b) revealed that the daily injection of 20 rat units of the estrus-producing hormone, obtained from the urine of pregnant cows, for 30 days in castrated male rabbits and in female rabbits castrated before puberty caused growth of the duct system of the mammary glands to the same extent as seen during continued estrus in normal female rabbits. Injection of the hormone of the corpus luteum had no effect on the growth of the mammary gland when given alone, but when injected simultaneously with estrogen it induced lobule-alveolar development characteristic of pregnancy (Turner and Frank, 1931); however, lactation was not produced. The answer to this observation came in the report by Strieker and Grueter (1928) that the anterior pituitary (AP) was- involved. These researchers, working in Bouin’s laboratory in Strasbourg, observed that milk secretion occurred when AP extracts were injected into pseudopregnant rabbits (see also Strieker and Grueter, 1929).

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References

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Authors and Affiliations

  1. Department of Dairy Husbandry, University of Missouri-Columbia, Columbia, Missouri, 65201, USA

    Charles W. Turner

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  1. Charles W. Turner
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Editors and Affiliations

  1. Iowa State University, Ames, Iowa, USA

    Horst-Dieter Dellmann

  2. University of Missouri, Columbia, Missouri, USA

    J. Alan Johnson  & David M. Klachko  & 

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© 1977 Plenum Press, New York

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Turner, C.W. (1977). Historical Perspectives of Lactogenic Hormone (Prolactin) a Summary of My Research at the University of Missouri. In: Dellmann, HD., Johnson, J.A., Klachko, D.M. (eds) Comparative Endocrinology of Prolactin. Advances in Experimental Medicine and Biology, vol 80. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6675-5_1

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  • DOI: https://doi.org/10.1007/978-1-4615-6675-5_1

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