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Fungal Infections in the Compromised Host

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Clinical Approach to Infection in the Compromised Host

Abstract

As the numbers of patients with host defenses compromised by disease and/or therapy have increased, so has the importance of invasive fungal infection as a cause of significant morbidity and mortality in this patient population. 1–6 The most important fungal infections in the compromised host are those caused by Candida and Aspergillus species, Mucoraceae, and Cryptococcus neoformans—organisms rightfully considered opportunistic invaders. The difference between fungal infection in the impaired host as opposed to the normal individual is strikingly demonstrated by a study from California that compared the types of fungal infection observed in different patient populations.2 Of 72 fungal infections occurring in immunocompromised people, 80% were caused by Candida,Aspergillus, and Mucoraceae, with an additional 12% caused by Cryptococcus; of 62 fungal infections occurring in normal hosts, 71% were caused by Coccidioides and Histoplasma, 5% by Cryptococcus, and none by Candida, Aspergillus, or Mucoraceae.

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References

  1. Bodey G: Fungal infections complicating acute leukemia. J Chron Dis 19: 667–687, 1966.

    Article  PubMed  CAS  Google Scholar 

  2. Hart PO, Russel E, Remington JS: The compromised host and infection. Deep fungal infection. J Infect Dis 120:169191, 1969.

    Google Scholar 

  3. DeGregorio M, Lee W, Linker C, et al: Fungal infections in patients with acute leukemia. Am JMed 73: 543–548, 1982.

    CAS  Google Scholar 

  4. Salaki JS, Louria DB, Chmel H: Fungal and yeast infections of the central nervous system. Medicine (Baltimore) 63:108–132, 1984.

    Google Scholar 

  5. Hawkins C, Armstrong D: Fungal infections in the immunocompromised host. Clin Haematol 13: 599–630, 1984.

    PubMed  CAS  Google Scholar 

  6. Gold JWM: Opportunistic fungal infections in patients with neoplastic disease. Am J Med 76: 458–463, 1984.

    Article  PubMed  CAS  Google Scholar 

  7. Evans EG: Diagnosis of systemic fungal infections. In Reeves D, Geddes A (eds): Recent Advances in Infection. Churchill Livingstone, Edinburgh, 1979, pp. 55–75.

    Google Scholar 

  8. Chandler F, Kaplan W, Ajello L (eds): Histopathology of Mycotic Diseases. Wolfe Medical, London, 1980.

    Google Scholar 

  9. Louria D: The usefulness of antibody tests in systemic fungal, yeasts and higher bacterial infections: A limited overview. In Baxter M (ed): Proceedings of the International Society for Human and Animal Mycology Palmerston North (New Zealand), Massey University, 1982, pp. 174177.

    Google Scholar 

  10. Penn R, Lambert R, George R: Invasive fungal infections. The use of serologic tests in diagnosis and management. Arch Intern Med 143:1215–1220, 1983.

    Google Scholar 

  11. Gordon MA, Gwinn DD: Summary of a workshop on serodiagnosis of systemic mycoses, J Infect Dis 146: 570574, 1982.

    Google Scholar 

  12. Stevens DA: Coccidioides immitis. In Mandell GC, Douglas GR, Bennett JE (eds): Principles and Practice of Infectious Diseases. Wiley, New York, 1985, pp. 1485–1493.

    Google Scholar 

  13. Goodwin RA, Des Prez RM: Histoplasma capsulatum. In Mandell GC, Douglas GR, Bennett JE (eds): Principles and Practice of Infectious Diseases. Wiley, New York, 1985, pp. 1468–1477.

    Google Scholar 

  14. Bennett JE: Aspergillus species. In Mandell GC, Douglas GR, Bennett JE (eds): Principles and Practice of Infectious Diseases. Wiley, New York, 1985, pp. 1447–1451.

    Google Scholar 

  15. Guinan M, Portas M, Hill H: The candida precipitation test in an immunosuppressed population. Cancer 43: 299–302, 1979.

    Article  PubMed  CAS  Google Scholar 

  16. Jones S, Bremman M, Kundsin R: Candida serology: An aid in diagnosis of deep-organ candidiasis. J Surg Res 14: 235237, 1973.

    Google Scholar 

  17. Taschdjian C, Kozinn P, Finck H, et al: Post mortem studies of systemic candidiasis. I. Diagnosis validity of precipitation reaction and probable origin of sensitization to cytoplasmic candidal antigens. Sabouraudia 7:110–117, 1969.

    Google Scholar 

  18. Diamond RD: Cryptococcus neoformans. In Mandell GC, Douglas GR, Bennett JE (eds): Principles and Practice of Infectious Diseases Wiley, New York, 1985, pp. 14601468.

    Google Scholar 

  19. Diamond RD, Bennett JE: Prognostic factors in cryptococcal meningitis. A study of 111 cases. Ann Intern Med 80:176181,1974.

    Google Scholar 

  20. Chapman SW: Blastomyces dermatidis. In Mandell GC, Douglas GR, Bennett JE (eds): Principles and Practice of Infectious Diseases Wiley, New York, 1985, pp. 14771485.

    Google Scholar 

  21. Araj G, Hopfer R, Chesnut S, et al: Diagnostic value of the enzyme-linked immunosorbent assay for detection of Candida albicans cytoplasmic antigen in sera of cancer patients. J Clin Microbiol 16: 46–52, 1982.

    PubMed  CAS  Google Scholar 

  22. Kerkering T, Espinell-Ingroff A, Shadomy S: Detection of Candida antigenemia by counterimmunoelectrophoresis in patients with invasive candidiasis. J Infect Dis 140: 659–664, 1979.

    Article  PubMed  CAS  Google Scholar 

  23. Lew M, Siber G, Donahue D, et al: Enhanced detection with an enzyme linked immunosorbent assay of Candida mannan in antibody containing serum after heat extraction. J Infect Dis 145: 45–56, 1982.

    Article  PubMed  CAS  Google Scholar 

  24. Meckstroth K, Reiss E, Keller J, et al: Detection of anti bodies and antigenemia in leukemia patients with candidiasis by enzyme linked immunosorbent assay. J Infect Dis 144: 24–32, 1981

    Article  PubMed  CAS  Google Scholar 

  25. Segal E, Berg R, Pizzo P, et al: Detection of Candida antigen in sera of patients with candidiasis by an enzyme-linked immunosorbent assay-inhibition technique. J Clin Microbial 10: 116–118, 1979.

    CAS  Google Scholar 

  26. Weiner M, Coats-Stephen M: Immunodiagnosis of systemic candidiasis: Mannan antigenemia detected by radioim munoassay in experimental and human infections. J Infect Dis 140: 989–993, 1979.

    Article  PubMed  CAS  Google Scholar 

  27. Weiner M, Yount W: Mannan antigenemia in the diagnosis of invasive candida infections. J Clin Invest 58:1045–1053, 1976.

    Google Scholar 

  28. Meunier-Carpentier F: Rapid diagnosis of fungal infections: Serology for antigen. In Baxter M (ed): Proceedings of the International Society for Human and Animal Mycology. Pal- merston North (New Zealand), Massey University, 1982, pp. 178–183.

    Google Scholar 

  29. Meunier-Carpentier F, Armstrong D: Candida antigenemia as detected by passive hemagglutination in patients with dis seminated candidiasis or candida colonization. J Clin Micro- biol13:10–14, 1981.

    Google Scholar 

  30. Meunier-Carpentier F, Kiehn T, Armstrong D: Fungemia in the immunocompromised host: Changing patterns, anti genemia high mortality. Am J Med 1: 363–370, 1981.

    Article  Google Scholar 

  31. Miller G, Witwer M, Braude A, et al: Rapid identification of C. albicans septicemia in man by gas liquid chromatography. J Clin Invest 54:1235–1240, 1974.

    Google Scholar 

  32. Kiehn T, Bernard E, Gold J, et al: Candidiasis: Detection by gas liquid chromatography of n-arabinitol, a fungal metabo lite in human sera. Science 206: 577–580, 1979.

    Article  PubMed  CAS  Google Scholar 

  33. Wong B, Bernard E, Gold J, et al: The arabinitol appearance rate in laboratory animals and humans: Estimation from the arabinitol/creatinine ratio and relevance to the diagnosis of candidiasis. J Infect Dis 146: 353–359, 1982.

    Article  PubMed  CAS  Google Scholar 

  34. Wong B, Bernard E, Gold J, et al: Increased arabinitol levels in experimental candidiasis in rats: Arabinitol appearance rates, arabinitol/creatinine ratios and severity of infection. J Infect Dis 146: 346–352, 1982.

    Article  PubMed  CAS  Google Scholar 

  35. Gold J, Wong B, Bernard E, et al: Serum arabinitol concentrations and arabinitol/creatinine ratios in invasive can-didiasis. J Infect Dis 147:504–513, 1983.

    Google Scholar 

  36. Andrews CP, Weiner MH: Aspergillus antigen detection in bronchoalveolar lavage fluid from patients with invasive aspergillosis and aspergillomas. Am J Med 73:372–380, 1982.

    Google Scholar 

  37. Weiner MH, Talbot GH, Gerson SL, et al: Antigen detection in the diagnosis of invasive aspergillosis. Ann Intern Med 99: 777–782, 1983.

    PubMed  CAS  Google Scholar 

  38. DeRepentigny L, Reiss E: Current trends in immunodiagnosis of candidiasis and aspergillosis. Rev Infect Dis 6:301-312, 1984.

    Google Scholar 

  39. Sabetta JR, Miniter P, Andriole VT: The diagnosis of invas-ive aspergillosis by an enzyme-linked immunoabsorbent assay for circulating antigen. J Infect Dis 152: 946–953, 1985.

    Article  PubMed  CAS  Google Scholar 

  40. Ahearn D: Medically important yeasts. Annu Rev Microbiol32: 59–68, 1978.

    Google Scholar 

  41. Gerain J, Snoeck R, Muller C, et al: Fongemie chez des malades immunocompromis. Med Mal Infect 14: 605–606, 1984.

    Article  Google Scholar 

  42. Louria D, Blevins A, Armstrong D, et al: Fungemia caused by “nonpathogenic” yeasts. Arch Intern Med 119: 247–252, 1967.

    Article  PubMed  CAS  Google Scholar 

  43. Wingard J, Merz W, Saral R: Candida tropicalis: A major pathogen in immunocompromised patients. Ann Intern Med 91: 539–543, 1979.

    PubMed  CAS  Google Scholar 

  44. Aisner J, Schimpff S, Sutherland J, et al: Torulopsis glabrata infections in patients with cancer; increasing incidence and relationship to colonization. Am J Med 61: 23–28, 1976.

    Article  PubMed  CAS  Google Scholar 

  45. Aisner J, Sickles E, Schimpff S, et al: Torulopsis glabrata pneumonitis in patients with cancer. JAMA 230: 584–585, 1974.

    Article  PubMed  CAS  Google Scholar 

  46. Kiehn T, Edwards F, Armstrong D: The prevalence of yeasts in clinical specimens from cancer patients. Am J Clin Pathol 73: 518–521, 1980.

    PubMed  CAS  Google Scholar 

  47. Plouffe J, Brown D, Silua J, et al: Nosocomial outbreak of Candida parapsilosis fungemia related to intravenous infu sions. Arch Intern Med 137: 1686–1689, 1977.

    Article  PubMed  CAS  Google Scholar 

  48. Baker J, Salkin I, Pincus D, et al: Pathogenicity of C. para tropicalis. Arch Pathol Lab Med 107: 577–579, 1983.

    PubMed  CAS  Google Scholar 

  49. Hurley R, Winner H: The pathogenicity of C. tropicalis. J Pathol 84: 33–38, 1962.

    Article  CAS  Google Scholar 

  50. Louria D, Stiff D, Bennett B: Disseminated moniliasis in the adult. Medicine (Baltimore) 41: 307–337, 1962.

    Google Scholar 

  51. Gold J, Poston W, Mertelsmann R, et al: Systemic infection with Trichosporon cutaneum in a patient with acute leuke mia. Cancer 48: 2163–2167, 1981.

    Article  PubMed  CAS  Google Scholar 

  52. Jameson B, Carter R, Watson J, et al: An unexpected fungal infection in a patient with leukemia. J Clin Pathol 34: 267 270, 1981.

    Google Scholar 

  53. Winston D, Balsley G, Rhodes J, et al: Disseminated Tri chosporon capitatum infection in an immunosuppressed host. Arch Intern Med 137: 1192–1195, 1977.

    Article  PubMed  CAS  Google Scholar 

  54. Lehrer RI: The fungicidal mechanisms of human monocytes. I. Evidence for myeloperoxidase-linked and myeloperox idase-independent candidacidal mechanisms. J Clin Invest 55: 338–346, 1975.

    Article  PubMed  CAS  Google Scholar 

  55. Diamond RD, Krzesicki R, Jao W: Damage to pseudohyphal forms of Candida albicans by neutrophils in the absence of serum in vitro, J Clin Invest 61: 349–359, 1978.

    Article  PubMed  CAS  Google Scholar 

  56. Diamond RD, Krzesicki R: Mechanisms of attachment of neutrophils to Candida albicans pseudohyphae in the ab sence of serum, and of subsequent damage to pseudohyphae by microbicidal process of neutrophils in vitro. J Clin Invest 61: 360–369, 1978.

    Article  CAS  Google Scholar 

  57. Diamond RD, Haudenschild CC: Monocyte-medidated serum-independent damage to hyphal and pseudohyphal forms of Candida albicans in vitro. J Clin Invest 67: 173–182, 1981.

    Article  PubMed  CAS  Google Scholar 

  58. Rogers TJ, Balish E: Immunity to Candida ablicans. Micro biol Rev 44: 660–682, 1980.

    CAS  Google Scholar 

  59. Bodey G: Candidiasis in cancer patients. Am J Med 77 (4D): 13–19, 1984.

    PubMed  CAS  Google Scholar 

  60. Maksymiuk A, Thongprasert S, Hopfer R, et al: Systemic candidiasis in cancer patients. Am J Med 77 (4D): 20–27, 1984

    PubMed  CAS  Google Scholar 

  61. Kantarjian H, Saad M, Estey E, et al: Hypercalcemia in disseminated candidiasis. Am J Med 77: 721–724, 1983.

    Article  Google Scholar 

  62. Fishman D, Griffin J, Sapico F, et al: Hematogenous Candida endophtalmitis. A complication of candidemia. N Engl J Med 286: 675–681, 1972.

    Google Scholar 

  63. Klein J, Watanakunakorn C: Hospital acquired fungemia. Its natural course and clinical significance. Am J Med 67: 5158, 1979.

    Article  Google Scholar 

  64. Montgomerie J, Edwards J: Association of infection due to Candida albicans with intravenous hyperalimentation. J Infect Dis 137:197–201, 1978.

    Google Scholar 

  65. Sixbey J, Caplan E: Candida parapsilosis endophthalmitis. Ann Intern Med 89:1010–1011, 1978.

    Google Scholar 

  66. Weinstein A, Relier B, Murphy J, et al: The clinical significance of positive blood cultures: A comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. Rev Infect Dis 5: 35–70, 1983.

    Article  PubMed  CAS  Google Scholar 

  67. Murray H, Fialk M, Roberts R: Candida arthritis: A manifestation of disseminated candidiasis. Am J Med 60: 587595, 1976.

    Google Scholar 

  68. Noble M, Lyne E: Candida osteomyelitis and arthritis from hyperalimentation therapy. J Bone Joint Surg 56B:825829, 1974.

    Google Scholar 

  69. Gazzamiga A, Mir-Sepasi M, Jefferies M, et al: Candida endocarditis complicating glucose total intravenous nutrition. Ann Surg 179: 902–905, 1974.

    Article  Google Scholar 

  70. Rubinstein E, Noriega E, Simberkoff M, et al: Fungal endocarditis: Characterization of the disease and response of the disease and response to therapy. Infect Immun 17:140–147, 1977.

    Google Scholar 

  71. Edwards JE: Candida endophthalmitis. In Remington JS, Swartz MN (eds): Current Clinical Topics in Infectious Disease. Vol. 3. McGraw-Hill, New York, 1982, pp. 381–397.

    Google Scholar 

  72. MacLeod R, Remington J: Fungal endocarditis. In Rahimtools S (ed): Infective Endocarditis. Grune und Stratton, New York, 1978, pp. 211–290.

    Google Scholar 

  73. Van Kirk J, Simon A, Armstrong W: Candida myocarditis causing complete atrioventricular block. JAMA 227:931933, 1974.

    Google Scholar 

  74. Pizzo P, Robichaud K, Edwards B, et al: Oral antibiotic prophylaxis in patients with cancer. J Pediatr 102:125–133, 1983.

    Google Scholar 

  75. Pizzo P, Robichaud K, Gill F, et al: Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia. Am J Med 72:101-I11, 1982.

    Google Scholar 

  76. Smits F, Prior A, Arblaster P: Incidence of Candida in hospitals in patients and the effects of antibiotic therapy. Br Med J 1: 208–210, 1966.

    Article  PubMed  CAS  Google Scholar 

  77. Eras P, Goldstein M, Sherlock P: Candida infection of the gastrointestinal tract. Medicine (Baltimore) 51: 367–379, 1972.

    CAS  Google Scholar 

  78. Jones J: Necrotizing Candida oesophagitis. Failure of symptoms and roentgenographic findings to reflect severity. JAMA 244: 2190–2191, 1980.

    Article  PubMed  CAS  Google Scholar 

  79. Jones J: Granulomatous hepatitis due to Candida albicans in patients with acute leukemia. Ann Intern Med 94: 475–477, 1981.

    PubMed  CAS  Google Scholar 

  80. Moseley R, Kris M, Einzig A, et al: Respiratory alkalosis and abdominal pain heralding Candida hepatitis. Arch Intern Med 142: 1495–1497, 1982.

    Article  PubMed  CAS  Google Scholar 

  81. Tashjian L, Abramson J, Peacock J: Focal hepatic candidiasis: A distinct clinical variant of candidiasis in immunocompromised patients. Rev Infect Dis 6: 689–703, 1984.

    Article  PubMed  CAS  Google Scholar 

  82. Marcucci R, Whitelly H, Armstrong D: Common bile duct obstruction secondary to infection with Candida. J Clin Microbiol 7: 490–492, 1978.

    PubMed  CAS  Google Scholar 

  83. Schreiber M, Black L, Noah Z, et al: Gallbladder candidias is in a leukemic child. Am J Dis Child 136: 462–463, 1982.

    PubMed  CAS  Google Scholar 

  84. Gordon R, Simmons B, Applebaum P, et al: Intraabdominal abscess and fungemia caused by Candida krusei. Arch Intern Med 140:1239–1240, 1980.

    Google Scholar 

  85. Solomkin J, Flohr A, Quie P, et al: The role of Candida in intraperitoneal infections. Surgery 88: 524–530, 1980.

    PubMed  CAS  Google Scholar 

  86. Solomkin J, Simmons R: Candida infection in surgical patients. World J Surg 4:381–394, 1980.

    Google Scholar 

  87. Eisenberg E, Alpert B, Weiss R, et al: Rhodotorula rubra peritonitis in patients undergoing continuous ambulatory peritoneal dialysis. Am J Med 75: 349–352, 1983.

    Article  PubMed  CAS  Google Scholar 

  88. Kerr C, Perfect J, Craven P, et al: Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis. Ann Intern Med 99: 334–337, 1983.

    PubMed  CAS  Google Scholar 

  89. Michigan S: Genitourinary fungal infections. J Urol 116: 390–397, 1976.

    PubMed  CAS  Google Scholar 

  90. Goldberg P, Kozinn P, Wise G, et al: Incidence and significance of candiduria. JAMA 241: 582–584, 1979.

    Article  PubMed  CAS  Google Scholar 

  91. Kozinn P, Taschdjian C, Goldberg F, et al: Advances in the diagnosis of renal candidiasis. J Urol 119:184–187, 1978.

    Google Scholar 

  92. Argyle C, Schumann GB, Genack L, et al: Identification of fungal casts in a patient with renal candidiasis. Hum Pathol 15: 480–481, 1984.

    Article  PubMed  CAS  Google Scholar 

  93. Gregory MC, Schumann GB: Antemortem diagnosis of disseminated fungal infection. N Engl J Med 312:124, 1985.

    Google Scholar 

  94. Gregory MC, Schumann GB, Schumann JL, Argyle JC: The clinical significance of candidal casts. Am J Kidney Dis 4:179–184, 1984.

    Google Scholar 

  95. Kauffman C, Tan J: Torulopsis glabrata renal infection. Am J Med 57: 217–224, 1974.

    Article  PubMed  CAS  Google Scholar 

  96. Boldus R, Brown R, Culp D: Fungus balls in the renal pelvis. Radiology 102: 555–557, 1972.

    PubMed  CAS  Google Scholar 

  97. Dembner A, Pfister R: Fungal infection of the urinary tract: Demonstration by antegrade pyelography and drainage by percutaneous nephrostomy. AJR 129:415–418, 1977.

    Google Scholar 

  98. McDonald D, Fagan C: Fungus balls in the urinary bladder. AJR 114: 753–757, 1972.

    CAS  Google Scholar 

  99. Armstrong D, Chmel H, Singer C, et al: Non-bacterial infections associated with neoplastic diseases. Eur J Cancer 11: 79–94, 1975.

    Article  PubMed  Google Scholar 

  100. Ellis C, Spivack M: The significance of candidemia. Ann Intern Med 67: 511–522, 1967.

    PubMed  CAS  Google Scholar 

  101. Krick J, Remington J: Opportunistic invasive fungal infection in patients with leukemia and lymphoma. Clin Haematol 5: 249–310, 1976.

    PubMed  CAS  Google Scholar 

  102. Masur H, Rosen P, Armstrong D: Pulmonary disease caused by Candida species. Am J Med 63: 914–925, 1977.

    Article  PubMed  CAS  Google Scholar 

  103. Rose H, Sheth N: Pulmonary candidiasis. A clinical and pathological correlation. Arch Intern Med 138: 964–965, 1978.

    Article  PubMed  CAS  Google Scholar 

  104. Bennett JE: Treatment of cryptococcal, candidal and coccidioidal meningitis. In Remington J, Swartz M (eds): Current Clinical Topics in Infectious Diseases. Vol. 2. McGraw-Hill, New York, 1981, pp. 54–67.

    Google Scholar 

  105. Chesney PJ, Teets KC, Mulvihill JJ, et al: Successful treatment of Candida meningitis with amphotericin B and 5fluorocytosine in combination. J Pediatr 89:1017–1019, 1976.

    Google Scholar 

  106. Chesney PJ, Justman RA, Bogdanowicz WM: Candida meningitis in new-born infants: A review and report of combined amphotericin B-fluocytosine therapy. Johns Hopkins Med J 142:155–160, 1978.

    Google Scholar 

  107. Lilien LD, Ramamurthy RS, Pildes RS: Candida albicans meningitis in a premature neonate successfully treated with 5-fluorocytosine and amphotericin B. A case report and review of the literature. Pediatrics 61: 57–61, 1978.

    PubMed  CAS  Google Scholar 

  108. Lipton S, Hickey W, Morris J, et al: Candidal infection in the central nervous system. Am J Med 76:101-108, 1984.

    Google Scholar 

  109. Parker JC, McCloskey JJ, Lee RS: The emergence of candidiasis: The dominant post mortem cerebral mycosis. Am J Clin Pathol 70: 31–36, 1978.

    PubMed  Google Scholar 

  110. DeVita V, Utz J, Carbone P: Candida meningitis. Arch Intern Med 117: 527–535, 1966.

    Article  PubMed  Google Scholar 

  111. Odds F: Candidosis of the central nervous system. In Odds (ed): Candida and Candidosis. University Park Press, Baltimore, 1979, pp. 166–170.

    Google Scholar 

  112. Cheml H: Candida albicans meningitis following lumbar puncture. Am J Med Sci 266: 465–467, 1973.

    Article  Google Scholar 

  113. Fainstein V, Hopfer R, Trier P, et al: Bone marrow cultures: their value in diagnosing fungal and fecal flora in patients with acute leukemia. J Infect Dis 144:79, 1981.

    Google Scholar 

  114. Bayer A, Guze L: Fungal arthritis. Candida arthritis: Diagnostic and prognostic implications and therapeutic considerations. Semin Arthritis Rheum 8:142–150, 1978.

    Google Scholar 

  115. Murray H, Fialk M, Roberts R: Candida arthritis: A manifestation of disseminated candidiasis. Am J Med 60: 587595, 1976.

    Google Scholar 

  116. Gerster J, Glauser M, Delacretaz F, et al: Erosive Candida arthritis in a patient with disseminated candidasis. J Rheumatol 7: 911–914, 1980.

    PubMed  CAS  Google Scholar 

  117. Shaikh BS, Applebaum PC, Aber RC: Vertebral disc space infection and osteomyelitis due to candida albicans in a patient with acute myelomonocytic leukemia. Cancer 45: 1025–1028, 1980.

    Article  PubMed  CAS  Google Scholar 

  118. Nobel M, Lyne E: Candida osteomyelitis and arthritis from hyperalimentation therapy. J Bone Joint Surg 56B:825829, 1984.

    Google Scholar 

  119. Dupont B, Drouhet E: Cutaneous, occular and osteoarticular candidiasis in heroin addict. J Infect Dis 152:577–591, 1985.

    Google Scholar 

  120. Epstein J, Tuazon C: Isolated lymphadenitis caused by Candida albicans in a patient with acute leukemia. Arch Intern Med 141:1697–1698, 1981.

    Google Scholar 

  121. Edwards J (moderator): Severe candidal infections: Clinical perspective, immune defense mechanisms and current concepts of therapy. Ann Intern Med 89:91–106, 1978.

    Google Scholar 

  122. Brownstein S, Mahoney-Kinsner J, Harris R: Ocular can-dida with pale-centered hemorrhages. Arch Ophthalmol 101:1745–1748, 1983.

    Google Scholar 

  123. Rinaldi MG: Invasive aspergillosis. Rev Infect Dis 5: 1061 1077, 1983.

    Google Scholar 

  124. Rhame ES, Streifel AJ, Kersey JH, et al: Extrinsic risk factors for pneumonia in the patient at high risk of infection. Am J Med (Suppl) 15: 42–52, 1984.

    Google Scholar 

  125. Arnow PM, Anderson RL, Mainous PD, et al: Pulmonary aspergillosis during hospital renovation. Am Rev Respir Dis 118:49–53, 1978.

    Google Scholar 

  126. Sarubbi FA Jr, Kopf HB, Wilson MB, et al: Increased recovery of Aspergillus flavus from respiratory specimens during hospital construction. Am Rev Respir Dis 125:33–38, 1982.

    Google Scholar 

  127. Streifet AJ, Lauer JL, Vesley D, et al: Aspergillus fumigatus and other thermotolerant fungi generated by hospital building demolition. Appl Environ Microbiol 46: 375–378, 1983.

    Google Scholar 

  128. Opal SM, Asp AA, Cannady PB Jr, et al: Efficacy of infection control measures during a nosocomial outbreak of disseminated aspergillosis associated with hospital construction. J Infect Dis 153: 634–637, 1986.

    Article  PubMed  CAS  Google Scholar 

  129. Young RC, Bennett JE, Vogel CL, et al: Aspergillosis: The spectrum of the disease in 98 patients. Medicine (Baltimore) 49:143–147, 1970.

    Google Scholar 

  130. Fischer BS, Armstrong D, Yu B, et al: Invasive aspergillosis. Progress in early diagnosis and treatment. Am J Med 71: 571–577, 1981.

    Article  Google Scholar 

  131. Meyer D, Young LS, Armstrong D, et al: Aspergillosis complicating neoplastic disease. Am J Med 54:6–15, 1973.

    Google Scholar 

  132. Pennington JE: Aspergillus lung disease. Med Clin North Am 64: 475–627, 1980.

    PubMed  CAS  Google Scholar 

  133. Brown E, Freedman S, Arbeit R, Come S: Invasive pulmonary aspergillosis in an apparently nonimmunocompromised host. Am J Med 69: 624–627, 1980.

    Article  PubMed  CAS  Google Scholar 

  134. Gerson SL, Talbot GH, Hurwitz S, et al: Prolonged granulocytopenia: The major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia. Ann Intern Med 100: 345–351, 1984.

    PubMed  CAS  Google Scholar 

  135. Ramsey PG, Rubin RH, Tolkoff-Rubin NE, et al: The renal transplant patient with fever and pulmonary infiltrates: Etiology, clinical manifestations and management. Medicine (Baltimore) 59: 206–222, 1978.

    Google Scholar 

  136. Weiland D, Ferguson RM, Peterson PK, et al: Aspergillosis in 25 renal transplant patients; epidemiology, clinical presentation, diagnosis and management. Ann Surg 198:622629,1983.

    Google Scholar 

  137. Gustafson TL, Schaffner W, Lavely GB, et al: Invasive aspergillosis in renal transplant recipient: Correlations with corticosteroid therapy. J Infect Dis 148: 230–238, 1983.

    Article  PubMed  CAS  Google Scholar 

  138. Cohen MS, Isturiz RE, Malech HL, et al: Fungal infection in chronic granulomatous disease; the importance of the phagocyte in defense against fungi. Am J Med 71: 59–66, 1981.

    Article  PubMed  CAS  Google Scholar 

  139. Schaffner A, Herndon D, Brande A: Selective protection against candida by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. J Clin Invest 69: 617–631, 1982.

    Article  CAS  Google Scholar 

  140. Levitz SM, Diamond RD: Changing pattems of aspergillosis infections, Adv. Intern Med 30:153–174, 1984.

    Google Scholar 

  141. Waldorf AR, Levitz SM, Diamond RD: In vivo bron-choalveolar macrophage defense against Rhizopus oryzae and Aspergillus fumigats. J Infect Dis 150: 752–760, 1984.

    Article  CAS  Google Scholar 

  142. Levitz SM, Diamond RD: Mechanisms of resistance of Aspergillus fumigatus Candida to killing by neutrophils in vitro. J Infect Dis 152: 33–41, 1985.

    Article  CAS  Google Scholar 

  143. Aisner J, Schimpf SC, Bennett JE, et al: Aspergillus infection in cancer patients. Association with fire proofing material in a new hospital. JAMA 235:411-412, 1976.

    Google Scholar 

  144. Cairns MR, Durack DT: Fungal pneumonia in the immunocompromised host. Semin Respir Infect 1:166–185, 1986.

    Google Scholar 

  145. Aisner J, Murrillo J, Schimpff SC, et al: Invasive aspergillosis in acute leukemia: Correlation with nose culture and antibiotic use. Ann Intern Med 90:4–9, 1979.

    Google Scholar 

  146. Albelda SM, Talbot GH, Gerson SL, et al: Role of fiberoptic bronchoscopy in the diagnosis of invasive pulmonary aspergillosis in patients with acute leukemia. Am J Med 76:1027–1034, 1984.

    Google Scholar 

  147. Stover DE, Zamman MB, Hajdu SI, et al: Bronchoalveolar lavage in the diagnosis of diffuse pulmonary infiltrates in the immunosuppressed host. Ann Intern Med 101:1–7, 1984.

    Google Scholar 

  148. Young LS: Diagnosis and treatment of diffuse pneumonias. In Grieco MH (ed): Infections in the Abnormal Host. Yorke, New York, 1980, pp. 601–622.

    Google Scholar 

  149. McCabe RE, Brooks RG, Mark JB, et al: Open lung biopsy in patients with acute leukemia. Am J Med 78: 609–616, 1985.

    Article  PubMed  CAS  Google Scholar 

  150. Aisner J, Schimpff SC, Wiernik PH: Treatment of invasive aspergillosis: Relation of early diagnosis and treatment to response. Ann Intern Med 86: 539–543, 1977.

    PubMed  CAS  Google Scholar 

  151. Beal MF, O’Carroll CP, Kleinman GM, et al: Aspergillosis of the nervous system. Neurology (NY) 32: 473–479, 1982.

    Article  CAS  Google Scholar 

  152. Morrow R, Wong B, Finkelstein WE, et al: Asgillosis of the cerebral ventricles in a heroin abuser. Arch Intern Med 143:161–164, 1983.

    Google Scholar 

  153. Doft BH, Clarkson JF, Rebell G, et al: Endogenous aspergillus endophthalmitis in drug abusers. Arch Ophthalmol 98: 859–862, 1980.

    Article  PubMed  CAS  Google Scholar 

  154. Morgan MA, Wilson WR, Meel HB, et al: Fungal sinusitis in healthy and immunocompromised individuals. Am J Pathol 82: 597–601, 1984.

    CAS  Google Scholar 

  155. Petrak RM, Pottage JC, Levin S: Invasive external otitis caused by Aspergillus fumigatus in an immunocompromised patient. J Infect Dis 151:196, 1985.

    Google Scholar 

  156. Kammer RB, Utz JP: Aspergillus species endocarditis. Am J Med 56: 506–521, 1974.

    Article  PubMed  CAS  Google Scholar 

  157. Byrd BF, Weiher MH, McGee ZA: Aspergillus spinal epidural abscess. JAMA 248:3138–3139, 1982.

    Google Scholar 

  158. Ingwer I, McLeish KR, Tight RD, et al: Aspergillus fumigatus epidural abscess in a renal transplant recipient. Arch Intern Med 138:153–154, 1978.

    Google Scholar 

  159. Schaffner A, Frick PG: The effect of ketoconazole on amphotericin B in a model of disseminated aspergillosis. J Infect Dis 151: 902–910, 1985.

    Article  PubMed  CAS  Google Scholar 

  160. Waldorf AR, Ruderman N, Diamond RD: Specific susceptibility to mucormycosis in murine diabetes and bronchoalveolar macrophage defense against Rhizopus. J Clin Invest 74: 150–160, 1984.

    Article  CAS  Google Scholar 

  161. Meyer RD, Rosen P, Armstrong D: Phycomycosis corn- 179.cidiodal meningitis. In Remington 1S, Swartz M (eds): Cur-rent Clinical Topics in Infectious Diseases. Vol. 2. McGraw-Hill, New York, 1981, pp. 54–67.

    Google Scholar 

  162. Masucci EF, Fabara JA, Saini M, et al: Cerebral mucor-mycosis in a heroin addict. Arch Neurol 139: 304 - 306, 1982.

    Article  Google Scholar 

  163. Abedi E, Sismanis A, Choi K, et al: Twenty-five years's experience treating cerebro-rhino-orbital mucormycosis. Laryngoscope 94:1060-1062, 1984.

    Google Scholar 

  164. Funada H, Misawa T, Nakao S, et al: The air crescent sign of invasive pulmonary mucomycosis in acute leukemia. Cancer 53: 2721 - 2723, 1984.

    Article  PubMed  CAS  Google Scholar 

  165. Bruck HM, Nash G, Foley FD, et al: Opportunistic fungal infection of the burn wound with phycomycetes and aspergillus. Arch Surg 102: 476 - 482, 1971.

    Article  PubMed  CAS  Google Scholar 

  166. Bateman CP, Umland ET, Becker LE: Cutaneous zygomycosis in a patient with lymphoma. J Am Acad De rmatol8:890-894, 1983.

    Google Scholar 

  167. Gartenberg G, Bottone EJ, Keusch GT, et al: Hospital-acquired mucormycosis (Rhizopus rhizopodiformis) of skin and subcutaneous tissue: Epidemiology, mycology and treatment. N Engl J Med 299:1115-1118, 1978.

    Google Scholar 

  168. Hoeprich PD: Cryptococcosis. In Hoeprich PD (ed): Infectious Diseases Harper und Row, New York, 1977, pp. 902910.

    Google Scholar 

  169. Bhattacharjee AK, Bennett JE, Glaudemans CPJ: Capsular polysaccharides of Cryptococcus neoformans. Ref Infect Dis 6: 619 - 624, 1984.

    Article  CAS  Google Scholar 

  170. Goodman JS, Kaufman L, Keonig MG: Diagnosis of cryptococcal meningitis: Value of immunologic detection of cryptococcal antigen. N Engl J Med 285: 434 - 436, 1971.

    Article  PubMed  CAS  Google Scholar 

  171. Wu TC, Koo SY: Comparison of 3 commercial cryptococcal latex kits for detection of cryptococcal antigen. J Clin Microbiol 18:1127-1130, 1983.

    Google Scholar 

  172. Bloomfield N, Gordon MA, Elmendorf DF: Detection of Cryptococcus neoformans antigen in body fluids by latex particle agglutination. Proc Soc Exp Biol Med 114: 64 - 67, 1963.

    PubMed  CAS  Google Scholar 

  173. Bennett JE, Bailey JW: Control for rheumatoid factor in the latex test for cryptococcosis. Am J Clin Pathol 56:360-365, 1971.

    Google Scholar 

  174. Snow RM, Dismukes WE: Cryptococcal meningitis. Diagnostic value of cryptococcal antigen in cerebrospinal fluid. Arch Intern Med 135: 1155 - 1157, 1975.

    Article  PubMed  CAS  Google Scholar 

  175. Mackinnon S, Kane JG, Parker RH: False-positive cryptococcal antigen test and cervical prevertebral abscess. JAMA 240:1982-1983, 1978.

    Google Scholar 

  176. Meunier-Carpentier F: Cryptococcal meningitis: A case report and review of diagnostic procedures and therapy. Acta Clin Belg 36: 300 - 302, 1981.

    PubMed  CAS  Google Scholar 

  177. Fujita NK, Reynard M, Sapico FL, et al: Cryptococcal inter-cerebral mass lesions. Ann Intern Med 94: 382 - 388, 1981.

    PubMed  CAS  Google Scholar 

  178. Kaplan MH, Rosen PP, Armstrong D: Cryptococcosis in a cancer hospital: Clinical and pathological correlates in 46 patients. Cancer 39: 2265 - 2274, 1977.

    Article  PubMed  CAS  Google Scholar 

  179. Bennett JE, Dismukes WE, Duma RJ, et al: A comparison of amphotent of cryptococal meningitis. N Engl J Med 301: 126 - 131, 1979

    Article  PubMed  CAS  Google Scholar 

  180. Bennett JE: Treatment of cryptoccal, candidal and coccidiodal meningitis. In Remington JS, Swartz M (eds): Current Clinical in Infectious Diseases. Vol. 2. McGraw-Hill, New York, 1981, pp. 54 - 67.

    Google Scholar 

  181. Campbell GD, Currier RD, Busey JF: Survival in untreated cryptococcal meningitis. Neurology (NY) 31: 1154–1157, 1981.

    Google Scholar 

  182. Fisher BD, Armstrong D: Cryptococcal interstitial pneumonia. N Engl J Med 297:1440–1441, 1977.

    Google Scholar 

  183. Jensen WA, Rose RM, Hammer SM, et al: Serologic diagnosis of focal pneumonia caused by Cryptococcus neoformans. Am Rev Respir Dis 132:189–191 1985.

    Google Scholar 

  184. Perfect JR, Durack DT, Gallis HA: Cryptococcemia. Medicine (Baltimore) 62:98–109, 1983.

    Google Scholar 

  185. Kovacs JA, Kovacs AA, Polis M, et al: Cryptococcosis in the acquired immunodeficiency syndrome. Ann Intern Med 103: 533–538, 1985.

    PubMed  CAS  Google Scholar 

  186. Zuger A, Louie E, Holzman RS, et al: Cryptococcal disease in patients with the acquired immunodeficiency syndrome; diagnostic features and outcome of treatment. Ann Intern Med 104: 234–240, 1986.

    PubMed  CAS  Google Scholar 

  187. Drutz DJ, Huppert M: Coccidioidomycosis: Factors affecting the host—parasite interaction. J Infect Dis 147: 372–390, 1983.

    Article  PubMed  CAS  Google Scholar 

  188. Deresinski SC, Stevens DA: Coccidioidomycosis in compromised hosts. Medicine (Baltimore) 54: 377–395, 1975.

    Article  CAS  Google Scholar 

  189. Craven PC, Graybill JR, Jorgensen JH, et al: High-dose ketoconazole for treatment of fungal infections of the central nervous system. Ann Intern Med 98:160–167, 1983.

    Google Scholar 

  190. Howard PF, Smith 1W: Diagnosis of disseminated coccidioidomycosis, by liver biopsy. Arch Intern Med 143:1335–1338, 1983.

    Google Scholar 

  191. Drutz DJ: Amphotericin B in the treatment of coccidioidomycosis, Drugs 26: 337–346, 1983.

    Article  PubMed  CAS  Google Scholar 

  192. Sarosi GA: Management of fungal diseases. Am Rev Respir Dis 127: 250–253, 1983.

    PubMed  CAS  Google Scholar 

  193. Catanzaro A, Einstein H, Levine B, et al: Ketoconazole for treatment of disseminated coccidioidomycosis. Ann Intern Med 96: 436–440, 1982.

    PubMed  CAS  Google Scholar 

  194. Galgiani JM: Ketoconazole in the treatment of coccidioidomycosis. Drugs 26: 355–363, 1983.

    Article  PubMed  CAS  Google Scholar 

  195. Wheat LJ, Slama TG, Zecfel ML: Histoplasmosis in the acquired immunodeficiency syndrome. Am J Med 78: 203210, 1985.

    Google Scholar 

  196. Wheat LJ, Slama TG, Norton JA, et al: Risk factors for disseminated or fatal histoplasmosis. Ann Intern Med 96:159–163, 1982.

    Google Scholar 

  197. Kaufman CA, Israel KS, Smith JW, et al: Histoplasmosis in immunosuppressed patients. Am J Med 64: 923–932, 1978.

    Article  Google Scholar 

  198. Lehmann PF, Gibbons J, Senitzer D, et al: T-lymphocyte abnormalities in disseminated histoplasmosis. Am J Med 75:790–794, 1983.

    Google Scholar 

  199. Murray JJ, Heim GR: Hypercalcemia in disseminated histoplasmosis. Am J Med 78: 881–884, 1985.

    Article  PubMed  CAS  Google Scholar 

  200. Schwarz J, Salfelder K: Blastomycosis: A review of 152 cases, Carr Top Pathol 65:165–200, 1977.

    Google Scholar 

  201. Bennett JE: Sporothrix schenckii. In Mandell GC, Douglas GR, Bennett JE (eds): Principles and Practice of Infectious Diseases. Wiley, New York, 1985, pp. 1456–1458.

    Google Scholar 

  202. Bennett JE: Miscellaneous fungi. In Mandell GC, Douglas GR, Bennett JE (eds): Principles and Practice of Infectious Diseases. Wiley, New York, 1985, pp. 1502–1504.

    Google Scholar 

  203. Yoo D, Lee HS, Kwong-Chung KJ: Brain abscesses due to Pseudoallescheria boydii associated with primary non-Hodgkin’s lymphoma of the central nervous system: A case report and literature review. Rev Infect Dis 7: 272–277, 1985.

    Article  PubMed  CAS  Google Scholar 

  204. Lutwick LI, Galgiani JN, Johnson RH, et al: Visceral fungal infections due to K. petriellidium boydii. Am J Med 61:632640, 1976.

    Google Scholar 

  205. Enggrano IL, Hughes WT, Kalwinsky DK, et a1: Pseudoallescheria boydii in a patient with acute lymphoblastic leukemia. Arch Pathol Lab Med 108: 619–622, 1984.

    Google Scholar 

  206. Shih L, Lee H: Disseminated petriellidiosis (allescheriasis) in a patient with refractory acute lymphoblastic leukemia. J Clin Pathol 37: 78–82, 1984.

    Article  PubMed  CAS  Google Scholar 

  207. Blazar BR, Hurd DD, Snover DC, Alexander JW, McGlave PB: Invasive Fusarium infections in bone marrow transplant recipients. Am J Med 77: 645–651, 1984.

    Article  PubMed  CAS  Google Scholar 

  208. Wheeler MS, McGinnis MR, Schell WA, et al: Fusarium infections in burned patients. Am J Clin Pathol 75:304–31 1, 1975.

    Google Scholar 

  209. Young HA, Kwong-Chung KJ, Kubota TT, et al: Disseminated infection by fusarium moniliforme during treatment for malignant lymphoma. J Clin Microbiol 77: 589–594, 1978.

    Google Scholar 

  210. Schimpff SC, Young V: Epidemiology and prevention of infection in the compromised host. In Rubin RH, Young L (eds): Clinical Approaches to Infection in the Compromised Host. Plenum, New York, 1981, pp. 5–33.

    Google Scholar 

  211. Pizzo PA: Empiric therapy and prevention of infection in the immunocompromised host. In Mandell GC, Douglas GR, Bennett JE (eds): Principles and Practice of Infectious Diseases. Wiley, New York, 1985, pp. 1468–1477.

    Google Scholar 

  212. Shaikh B, Appelbaum P, Jones J, et al: Colonization of nasal ulcers as a source of Candida parapsilosis fungemia. Arch Otolaryngol 106: 434–436, 1980.

    Article  PubMed  CAS  Google Scholar 

  213. Schimpff S: Infection prevention during granulocytopenia. In Remington JS, Swartz M (eds): Current Clinical Topics in Infectious Diseases. McGraw-Hill, New York, 1980, pp. 85–106.

    Google Scholar 

  214. Meunier-Carpentier F: Chemoprophylaxis of fungal infections. Am J Med 76: 652–666, 1984.

    Article  PubMed  CAS  Google Scholar 

  215. DeGregorio M, Lee W, Ries C: Candida infections in patients with acute leukemia: Ineffectiveness of nystatin prophylaxis and relationship between oropharyngeal and systemic candidiasis. Cancer 50: 2780–2784, 1982.

    Article  PubMed  CAS  Google Scholar 

  216. Jones W, Kauffman C, McAuliffe L, et al: Efficacy of ketoconazole versus nystatin in prevention of fungal infection in neutropenic patients. Arch Intern Med 144: 549–551, 1984.

    Article  PubMed  CAS  Google Scholar 

  217. Dekker A, Rozenberg-Arska M, Sixma J, et al: Prevention of infection by trimethoprim-sulfamethoxazole plus amphotericin B in patients with acute non-lymphocytic leukemia. Ann Intern Med 95: 555–559, 1981.

    PubMed  CAS  Google Scholar 

  218. Bodey G, Rosenbaum B: Effect of prophylactic measures on the microbial flora of patients in protected environment units, Medicine (Baltimore) 53: 209–228, 1974.

    Article  CAS  Google Scholar 

  219. Schimpff S, Greene W, Young V, et al: Infection prevention in non-lymphocytic leukemia. Ann Intern Med 82:351–368, 1975.

    Google Scholar 

  220. Schimpff S, Young V, Greene W, et al: Origin of infection in acute non-lymphocytic leukemia. Significance of hospital acquisition of potential pathogens. Ann Intern Med 77:707714, 1972.

    Google Scholar 

  221. Bodey G: The effect of amphotericin Bon the fungal flora in feces. Clin Pharmacol Ther 10: 675–680, 1969.

    PubMed  CAS  Google Scholar 

  222. Ezdinli E, O’Sullivan D, Wasser L, et al: Oral amphotericin for candidiasis in patients with haematologic neoplasms: An autopsy study. JAMA 424: 258–260, 1979.

    Article  Google Scholar 

  223. Bodey G, Rosenbaum B, Valdivieso M, et al: Effect of systemic antimicrobial prophylaxis on microbial flora. Antimicrob Agents Chemother 21: 367–372, 1982.

    Article  PubMed  CAS  Google Scholar 

  224. Meunier-Carpentier F, Cruciani M, Klastersky J: Oral prophylaxis with miconazole or ketoconazole of invasive fungal disease in neutropenic cancer patients. Eur J Cancer Clin Oncol 19: 43–48, 1983.

    Article  PubMed  CAS  Google Scholar 

  225. Kaufman C, Jones P, Bergman A, et al: Effect of prophylactic ketoconazole and nystatin on fungal flora. Mykosen 27:165–172, 1983.

    Google Scholar 

  226. Estey E, Maksymiuk A, Smith T, et al: Infection prophylaxis in acute leukemia. Arch Intern Med 144:1562–1568, 1984.

    Google Scholar 

  227. Hann I, Prentice H, Corringham R, et al: Ketoconazole versus nystatin plus amphotericin B for fungal prophylaxis in severely immunocompromised patients. Lancet 1: 826–829, 1982.

    Article  PubMed  CAS  Google Scholar 

  228. Acuna G, Winston D, Young L: Ketoconazole prophylaxis of fungal infections in the granulocytopenic patient. ICAAC Abst. no. 852, 1981.

    Google Scholar 

  229. DeJongh C, Finley R, Joshi J, et al: A comparison of ketoconazole to nystatin: Prophylaxis of fungal infection in neutropenic patients. ICAAC Abst. no. 497, 1982.

    Google Scholar 

  230. Shepp D, Klosterman A, Seigel M, et al: Comparison of patients treated in protective environment. ICAAC Abst. no. 1101, 1983.

    Google Scholar 

  231. Young L: The outlook for antifungal prophylaxis in the compromised host. J Antimicrob Chemother 9: 338–340, 1982.

    Article  PubMed  CAS  Google Scholar 

  232. Owens M, Nighingale C, Schweizer R, et al: Prophylaxis of oral candidiasis with clotrimazole troches. Arch Intern Med 144: 290–293, 1984.

    Article  PubMed  CAS  Google Scholar 

  233. Meunier-Carpentier F: Prevention of fungal pneumonia in the immunocompromised host. In Lode H, Kemmrich B, Klastersky J (eds): Current Aspects of Bacterial and Non-Bacterial Pneumonias Thieme, Stuttgart, 1984, pp. 176183.

    Google Scholar 

  234. Wade J, Schimpff S, Hargadon M, et al: A comparison of trimethaprim-sulfamethoxazole plus nystatin with gentamicin plus nystatin in the prevention of infections in acute leukemia. N Engl J Med 304:1057–1062, 1981.

    Google Scholar 

  235. Meunier-Carpentier F, Snoeck R, Gerain J, et al: Amphotericin B nasal spray as prophylaxis against aspergillosis in patients with neutropenia. N Engl J Med 311:1056 1984.

    Google Scholar 

  236. Arnow PW, Andersen RL, Mainous D, et al: Pulmonary aspergillosis during hospital renovation. Am Rev Respir Dis 118: 49–53, 1978.

    PubMed  CAS  Google Scholar 

  237. Poelvoorde J, Devroey C: Sources d’Aspergillus fumigatus en milieu hospitalier. Bull Soc Fr Mycol Med 12: 85–88, 1983.

    Google Scholar 

  238. Bodey GP, Johnston D: Microbiological evaluation of protected environment during patient occupancy. Appl Microbial 22: 828–836, 1971.

    CAS  Google Scholar 

  239. Dreizen S: Oral candidiasis. Am J Med 77(4D):28-33, 1984.

    Google Scholar 

  240. Ching M, Raymond K, Bury R, et al: Absorption of orally administered amphotericin B lozenges. Br J Clin Pharm 16:106–108, 1983.

    Google Scholar 

  241. Kravetz H, Andriole V, Huber M, et al: Oral administration of solubilized amphotericin B. N Eng! J Med 265:183–184 1961.

    Google Scholar 

  242. Louria D: Some aspects of the absorption, distribution and excretion of amphotericin B in man. Antibiot Med Clin Ther 5: 295–301, 1958.

    CAS  Google Scholar 

  243. Armstrong D, Gold J: Treatment of opportunistic mycoses in the immunodepressed patient. In Speller DCE (ed): Anti-fungal Chemotherapy Wiley, New York, 1980, pp. 333364.

    Google Scholar 

  244. Medoff G, Kobayashi G: Strategies in the treatment of systemic fungal infections. N Eng! J Med 302:145–155 1980.

    Google Scholar 

  245. Meunier-Carpentier F: Combination of antifungal agents for systemic mycotic diseases. In Klastersky J, Staquet M (eds): Combination Antibiotic Therapy in the Compromised Host. Raven, New York, 1982, pp. 207–227.

    Google Scholar 

  246. Drutz D: Newer antifungal agents and their use, including an update on amphotericin B and flucytosine. In Remington J, Swartz M (eds): Current Clinical Topics in Infectious Diseases. Vol. III. McGraw-Hill, New York, 1982, pp. 97135.

    Google Scholar 

  247. Burks L, Aisner J, Fortner C, et al: Meperidine for the treatment of shaking chills and fever. Arch Intern Med 140: 483484, 1980.

    Google Scholar 

  248. Butler W, Bennett J, Hill G III, et al: Electrocardiographic and electrolyte abnormalities caused by amphotericin B in dog and man. Proc Soc Exp Bio! Med 116: 857–863, 1964.

    CAS  Google Scholar 

  249. Utz J: Amphotericin B toxicity: Combined clinical staff conference at the NIH. General side effects. Ann Intern Med 61: 334–340, 1964.

    CAS  Google Scholar 

  250. Craven PC, Gremillion DH: Risk factors of ventricular fibrillation during rapid amphotericin B infusion. Antimicrob Agents Chemother 27: 868–871, 1985.

    Article  PubMed  CAS  Google Scholar 

  251. Wright D, Robichaud K, Pizzo P, et al: Lethal pulmonary reactions associated with the combined use of amphotericin B and leukocyte transfusions. N Eng! J Med 304:1185— 1189, 1981.

    Google Scholar 

  252. Bow E, Schroeder M, Louie T: Pulmonary complications in patients receiving granulocyte transfusions and amphotericin B. Can Med Assoc J 130: 593–597, 1984.

    PubMed  CAS  Google Scholar 

  253. Dana B, Dune B, White R, et al: Concomitant administration of granulocyte transfusions and amphotericin B in neutropenic patients: Absence of significant pulmonary toxicity. Blood 57: 90–94, 1981.

    PubMed  CAS  Google Scholar 

  254. Ismail MA, Lemer SA: Disseminated blastomycosis in a pregnant woman. Am Rev Respir Dis 126: 350–353, 1982.

    PubMed  CAS  Google Scholar 

  255. Posner J: Reservoirs for intraventricular chemotherapy. N Engl J Med 288: 212–213, 1973.

    Article  PubMed  CAS  Google Scholar 

  256. Bayer A, Edwards J, Guze E: Experimental intraabdominal candidiasis in rabbits: Therapy with low total dose intravenous amphotericin B. Antimicroh Agents Chemother 19: 179–184, 1982.

    Article  Google Scholar 

  257. Wise G, Kozinn P, Goldberg P: Amphotericin B as a urologic irrigant in the management of noninvasive candiduria. J Urol 124: 70–72, 1982.

    Google Scholar 

  258. Rahko P, Davey P, Wheat J. et al: Treatment of Torulopsis glabrata peritonitis with intraperitioneal amphotericin B. JAMA 249:1187–1188, 1983.

    Google Scholar 

  259. Bayer A, Blumenkrantz M, Montgomerie J, et al: Candida peritonitis: Report of 22 cases and review of the English literature. Am J Med 61: 832–840, 1976.

    Article  PubMed  CAS  Google Scholar 

  260. Bennett J: Flucytosine. Ann Intern Med 86: 319–322, 1977.

    Google Scholar 

  261. White C, Traube J: Ulcerating enteritis associated with flucytosine therapy. Gastroenterology 83:1127–1129, 1982.

    Google Scholar 

  262. Wise G, Kozinn P, Goldberg P: Flucytosine in the management of genitourinary candidiasis: Five years of experience. J Urol 124: 70–72, 1980.

    PubMed  CAS  Google Scholar 

  263. Wise G, Weinstein S, Goldberg P, et al: Flucytosine in nary Candida infections. Urology 3: 708–711, 1974.

    Article  PubMed  CAS  Google Scholar 

  264. Diasio R, Lakings D, Bennett J: Evidence for conversion of 5-FC to 5-FU in humans. Antimicrob Agents Chemother 14: 903–908, 1978.

    Article  PubMed  CAS  Google Scholar 

  265. Kauffman C, Frame P: Bone marrow toxicity associated with 5-FC therapy. Antimicrob Agents Chemother 11:244247,1977.

    Google Scholar 

  266. Fainstein V, Bodey G: Cardiorespiratory toxicity due to miconazole. Ann Intern Med 93: 432–433, 1980.

    PubMed  CAS  Google Scholar 

  267. Deresinski S, Lilly R, Levine H, et al: Treatment of fungal meningitis with miconazole. Arch Intern Med 137:11801185, 1977.

    Google Scholar 

  268. Sung J, Grendahl J, Levine M: Intravenous and intrathecal miconazole therapy for systemic mycosis. West J Med 126:5–13, 1977.

    Google Scholar 

  269. Lutwick LI, Rytel MW, Yanez JP, et al: Deep infections from Petriellidium hoydü treated with miconazole. JAMA 241: 272–273, 1979.

    Article  PubMed  CAS  Google Scholar 

  270. Duarte P, Chow C, Simmons F, et al: Fatal hepatitis associated with ketoconazole therapy. Arch Intern Med 144:10691070, 1984.

    Google Scholar 

  271. Heiberg J, Svejgaard E: Toxic hepatitis during ketoconazole treatment. Br Med J 283:825–826, 1981.

    Google Scholar 

  272. Horsburgh C, Kirkpatrick C, Teusch C: Ketoconazole and the liver. Lancet 1: 860, 1982.

    Article  Google Scholar 

  273. Lewis J, Zimmerman J, Benson G, et al: Hepatic injury associated with ketoconazole therapy. Gastroenterology 86: 503–513, 1984.

    PubMed  CAS  Google Scholar 

  274. Svejgaard E, Ramck L: Hepatic dysfunction and ketoconazole therapy. Ann Intern Med 96: 788–789, 1982.

    PubMed  CAS  Google Scholar 

  275. Defelice R, Johnson D, Galgiani J: Gynecomastia with ketoconazole. Antimicrob Agents Chemother 19:1073–1074, 1981.

    Google Scholar 

  276. Grosso D, Boyden T, Parmentier R, et al: Ketoconazole inhibition of testicular secretion of testosterone and displacement of steroid hormones from serum transport proteins. Antimicrob Agents Chemother 23:207-212, 1983.

    Google Scholar 

  277. Pont A, Williams P, Azhar S, et al: Ketoconazole blocks testosterone synthesis. Arch Intern Med 142: 2137–2140, 1982.

    Article  PubMed  CAS  Google Scholar 

  278. Schurmeyer T, Nieschlag E: Effect of ketoconazole and other imidazole fungicides on testosterone biosynthesis. Acta Endocrinol (Copenh) 105: 275–280, 1984.

    CAS  Google Scholar 

  279. Pont A, William P, Coose D, et al: Ketoconazole blocks adrenal steroid synthesis. Ann Intern Med 97: 370–372, 1982.

    PubMed  CAS  Google Scholar 

  280. Tucker WS, Snell BB, Island DP, et al: Reversible adrenal insufficiency induced by ketoconazole. JAMA 253: 2413 2414, 1985.

    Google Scholar 

  281. Meunier F: Serum fungistatic and fungicidal activity in volunteers receiving antifungal agents, Eur J Clin Microh 5:103–109, 1986.

    Google Scholar 

  282. Engelhard D, Stutman HR, Marks MI: Interaction of ketoconazole with rifampin and isoniazid. N Engl J Med 311:1682–1683, 1984.

    Google Scholar 

  283. Daneshemend T Ketoconazole-cyclosporin interaction, Lancet 2:1342–1343 1982.

    Google Scholar 

  284. Ferguson R, Sutherland D, Simmons R, et al: Ketoconazole, cyclosporin metabolism and renal transplantation. Lancet 2: 882–883, 1982.

    Article  PubMed  CAS  Google Scholar 

  285. Morgenstern G, Powles R, Robinson B, et al: Cyclosporin interaction with ketoconazole and melphalan. Lancet 2:1342 1982.

    Google Scholar 

  286. Brown MW, Maldonado AL, Meredith CG, et al: Effect of ketoconazole on hepatic oxidative drug metabolism. Clin Pharmacol Ther 37:290–297, 1985.

    Google Scholar 

  287. Horsburgh C, Kirkpatrick C: Long-term therapy of chronic mucocutaneous candidosis with ketoconazole: Experience with twenty-one patients. Am J Med 74:23–29, 1983.

    Google Scholar 

  288. Bennett JE: Antifungal agents. In Mandell GC, Douglas GR, Bennett JE (eds): Principles and Practices of Infectious Diseases. Wiley, New York, 1985, pp. 263–270.

    Google Scholar 

  289. Meunier F: Prevention of mycoses in immunocompromised patients, Rev Infect Dis 9: 408–416, 1987.

    Article  PubMed  CAS  Google Scholar 

  290. Stein R, Kayser J, Klenher J: Clinical value of empirical amphotericin B in patients with acute myelogenous leukemia. Cancer 50: 2247–2251, 1982.

    Article  PubMed  CAS  Google Scholar 

  291. Christiansens K, Bernard E, Gold J, et al: Distribution and activity of amphotericin B in humans. J Infect Dis 152:1037–1043, 1985.

    Google Scholar 

  292. Smego RA, Perfect JR, Durack DT: Combined therapy with amphotericin B and 5-fluorocytosine for candida meningitis. Rev Infect Dis 6: 791–801, 1984.

    Article  PubMed  Google Scholar 

  293. Horn R, Wong B, Kiehn T, et al: Fungemia in a cancer hospital: changing frequency, earlier onset and results of therapy, Rev Infect Dis 7: 646–656, 1985.

    Article  PubMed  CAS  Google Scholar 

  294. Schaffner A, Frick PG: The effect of ketoconazole on amphotericin B in a model of disseminated aspergillosis. J Infect Dis 151: 902–910, 1985.

    Article  PubMed  CAS  Google Scholar 

  295. Merz W: Candida lusitaniac: Frequency of recovery, colonization, infection and amphotericin B resistance. J Clin Microhiol 20:1194–1195, 1984.

    Google Scholar 

  296. Merz W, Sandford G: Isolation and characterization of a polyene resistant variant of C. tropicalis. J Clin Microhiol 9:677–6801979.

    Google Scholar 

  297. Pappagianis D, Collins M, Hector R, et al: Development of resistance to amphotericin B in Candida lusitaniae infecting a human. Antimicrob Agents Chemother 16:123–126, 1979.

    Google Scholar 

  298. Dick J, Merz W, Saral R: Incidence of polyene-resistant yeasts recovered from clinical specimens. Antimicrob Agents Chemother 18:158–163, 1980

    Google Scholar 

  299. Guinet R, Chanas J, Goullier A, et al: Fatal septicemia due amphotericin B-resistant C. lusitaniae, J Clin Microbiol 18: 433–444, 1983.

    Google Scholar 

  300. Stiller R, Bennett J, Scholer H, et al: Susceptibility to 5-FC and prevalence of serotype in 402 C. albicans isolates in the US, Antimicrob Agents Chemother 22: 482–487, 1982.

    Article  PubMed  CAS  Google Scholar 

  301. Stiller R, Bennett J, Scholer H, et al: Correlation of in vitro susceptibility test results with in vivo response: Flucytosine therapy in a systemic candidiasis model, J Infect 147:1070–1077, 1983.

    Google Scholar 

  302. Ruthe R, Andersen B, Epstein R: Efficacy of granulocyte transfusions in the control of systemic candidiasis in the leukopenic host, Blood 53: 493–498, 1978.

    Google Scholar 

  303. Swerdlow B, Deresinski S: Development of Aspergillus si nusitis in a patient receiving Amphotericin B treatment with granulocyte transfusions, Am J Med 76:162–166, 1984

    Google Scholar 

  304. Meunier-Carpentier F, Taterman J, Brassinne C, et al: In-vitro activity of amphotericin B encapsulated into liposomes. 1CAAC Abst. no. 1020, 1984.

    Google Scholar 

  305. Meunier-Carpentier F, Coune A, Sculier JP, et al: Serum 28:815–818, 1985. levels of amphotericin B, serum fungistatic and fungicidal activity in cancer patients receiving FungizoneR or amphotericin B encapsulated into liposomes. ICACC Abst. no. 1056, 1985.

    Google Scholar 

  306. Sculier JP, Coune A, Meunier F, et al: Pilot study of amphotericin B entrapped into sonicated liposomes in cancer patients with mycotic complications, ASCO Annual Meeting, Abst. no. 964, 1986.

    Google Scholar 

  307. Lopez-Bernstein G, Fainstein V, Hopfer R, et al: Liposomal amphotericin B for the treatment of systemic fungal infec tions in patients with cancer: A preliminary study. J Infect Dis 151: 704–710, 1985.

    Article  Google Scholar 

  308. Espinel-Ingroff A, Shadomy S, Gebhart RJ: In vitro studies with R-51,211 (Itraconazole). Antimicrob Agents Chemother 26: 5–9, 1984.

    Article  PubMed  CAS  Google Scholar 

  309. Van Cutsem J, Van Gerven F, Van de Ven MA, et al: Itraconazole, a new triazole that is orally active in as pergillosis. Antimicrob Agents Chemother 26: 527–534, 1984.

    Article  PubMed  Google Scholar 

  310. Humphrey M, Jevons S, Tarbit M: Pharmacokinetic evalua tion of UK-49,858, a metabolically stable triazole anti fungal drug, in animals and humans, Antimicrob Agents Chemother 28: 648–653, 1985.

    Article  PubMed  CAS  Google Scholar 

  311. Troke P, Andrews R, Brammer K, et al: Efficacy of UK 49,858 (Fluconazole) against Candida albicans experimen tal infections in mice, Antimicrob Agents Chemother 28: 815–818, 1985.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine and Henri Tagnon Laboratory of Clinical Investigation, Section of Microbiology and Infectious Diseases Unit, Jules Bordet Institute, 1000, Brussels, Belgium

    Françoise Meunier

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  1. Françoise Meunier
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  1. Infectious Disease and Transplantation Units, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, 02114, Boston, Massachusetts, USA

    Robert H. Rubin M.D.

  2. Kuzell Institute for Arthritis and Infectious Diseases, Division of Infectious Diseases, Pacific Presbyterian Medical Center, 94115, San Francisco, California, USA

    Lowell S. Young M.D.

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Meunier, F. (1988). Fungal Infections in the Compromised Host. In: Rubin, R.H., Young, L.S. (eds) Clinical Approach to Infection in the Compromised Host. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6645-8_8

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  • DOI: https://doi.org/10.1007/978-1-4615-6645-8_8

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