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Central Nervous System Infections in the Compromised Host

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Clinical Approach to Infection in the Compromised Host

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Abstract

Meningitis and other types of central nervous system (CNS) infection in the immunocompromised patient are usually caused by different organisms than in the general population.1–3 For instance, Streptococcus pneumoniae or Neisseria meningitidis may produce meningitis in an immunocompromised patient, but it is more common to find Listeria monocytogenes or Pseudomonas aeruginosa as the cause. The latter organisms may cause meningitis in the general population, but much less commonly as compared with the Pneumococcus or the Meningococcus.4–6 Similarly, the most common type of brain abscess seen in the general population is caused by mixed aerobic and anaerobic bacterial flora7–8 by a process that generally extends from the nasopharynx. In contrast, Aspergillus fumigatus 9–10 or Nocardia asteroides 11, 12 more frequently cause brain abscess in the immunocompromised patient,1,2 and the apparent route of access is hematogenous.

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Authors and Affiliations

  1. Department of Medicine, Infectious Disease Service and Microbiology Laboratory, Memorial Sloan-Kettering Cancer Center, Cornell University Medical College, New York, New York, 10021, USA

    Donald Armstrong & Bruce Polsky

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  1. Donald Armstrong
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Editors and Affiliations

  1. Infectious Disease and Transplantation Units, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

    Robert H. Rubin M.D.

  2. Division of Infectious Diseases, Pacific Presbyterian Medical Center, Kuzell Institute for Arthritis and Infectious Diseases, San Francisco, California, USA

    Lowell S. Young M.D.

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Armstrong, D., Polsky, B. (1988). Central Nervous System Infections in the Compromised Host. In: Rubin, R.H., Young, L.S. (eds) Clinical Approach to Infection in the Compromised Host. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6642-7_7

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