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Alkylating Agents and the Nitrosoureas

  • Chapter
Chemotherapy

Part of the book series: Cancer ((C,volume 5))

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Abstract

The alkylating agents as a group have long held the interest of both practical cancer chemotherapists and experimental pharmacologists. They have assumed this position of importance because they were among the first clinical agents of recognized value, and because their study has increased our understanding of cancer chemotherapy in general. At a molecular level, interest in alkylating agents has led to studies of alterations in DNA structure, and to investigations of the repair of chemically induced damage to DNA. Interest in cyclophosphamide has led to important studies of drug metabolism, while interest in the distribution of alkylating agents has led to investigations of drug transport. Besides these and other contributions in the area of cancer chemotherapy, studies of alkylating agents have also increased our understanding of mutagenesis and chemical carcinogenesis.

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  1. Department of Pharmacology and Experimental Therapeutics, Albany Medical College, New York, Albany, 12208, USA

    David B. Ludlum

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  1. M.D. Anderson Hospital and Tumor Institute, University of Texas System Cancer Center, Houston, Texas, USA

    Frederick F. Becker

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Ludlum, D.B. (1977). Alkylating Agents and the Nitrosoureas. In: Becker, F.F. (eds) Chemotherapy. Cancer, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6628-1_10

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