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Factors That Influence the Therapeutic Response

  • Chapter
Chemotherapy

Part of the book series: Cancer ((C,volume 5))

Abstract

The use of drugs in the treatment of malignancies is of much more recent origin than the use of surgery or radiation therapy. The first recorded clinical trial of a chemotherapeutic agent took place in 1942, when nitrogen mustard was given to a patient with advanced lymphosarcoma (Goodman et al., 1946). A dramatic but unfortunately brief tumor response was achieved in this patient. Later in that same decade, Sidney Farber observed what he termed an “acceleration phenomenon” in a retrospective analysis of children with acute leukemia treated with folate conjugates. This experience led him to a trial of folate antagonists, and in 1948, he reported dramatic responses in 10 of 16 children treated with the folate antagonist aminopterin (Farbet et al., 1948).

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Authors and Affiliations

  1. Section of Medical Oncology, Departments of Medicine and Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA

    Gerard T. Kennealey & Malcolm S. Mitchell

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  1. Gerard T. Kennealey
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  1. M.D. Anderson Hospital and Tumor Institute, University of Texas System Cancer Center, Houston, Texas, USA

    Frederick F. Becker

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Kennealey, G.T., Mitchell, M.S. (1977). Factors That Influence the Therapeutic Response. In: Becker, F.F. (eds) Chemotherapy. Cancer, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6628-1_1

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