Abstract
The hormonal concept of carcinogenesis was initiated by the intuitive studies of Beatson (1896) on the relation of breast cancer to the ovary. Epidemiological studies of mammary tumors of highly inbred strains of mice led Bittner and his associates (Bittner, 1946–1947) to the recognition of genetic, viral, and hormonal components in the development of breast cancer. Independently, Rous and Kidd (1941), on the basis of experimental studies on induction of skin cancers with carcinogens, advanced the multifactorial concept of tumorigenesis and postulated the existence of latent cancer cells. The recognition of “progression” during the course of neoplastic disease was best conceived by Foulds (cf. 1969). Finally, the recognition of immunosurveillance (Burnet, 1970; Jerne, 1973; Klein, 1973–1974) and of immunological and hormonal factors capable of restraining or enhancing tumor growth completed the picture of the complexity of forces involved in initiation and growth of tumors. The last of these—hormones—is reviewed here in light of all other forces.
Supported by USPHS grant CA-02332 from the National Cancer Institute. Prepared with the technical and editorial assistance of Mrs. Judith Grauman.
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Furth, J. (1982). Hormones as Etiological Agents in Neoplasia. In: Becker, F.F. (eds) Etiology: Chemical and Physical Carcinogenesis. Cancer, A Comprehensive Treatise. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6598-7_4
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