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Effect of Ethanol on Intracellular Respiration and Cerebral Function

  • Chapter
The Biology of Alcoholism

Abstract

As yet, there is no satisfactory explanation of the mechanism of the anesthetic action of any compound classified as a general depressant, including ethanol. This lack of knowledge is basically due to our limited insight into how the central nervous system works. Anesthetic agents cause changes in both function and metabolism of the brain. Consequently, depression of energy-yielding metabolic reactions as well as direct action on the excitable membranes have been proposed as alternative explanations of narcosis, as in Verworn’s (1912) asphyxial hypothesis or Meyer-Overton’s classical formulation from 1901–1902 which suggests solubility in membrane lipoids as the basis for anesthetic potency.

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  1. Research Laboratories of the State Alcohol Monopoly (Alko), Helsinki, Finland

    Henrik Wallgren

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  1. Henrik Wallgren
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  1. Division of Alcoholism and Drug Dependence Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, New York, USA

    Benjamin Kissin  & Henri Begleiter  & 

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Wallgren, H. (1971). Effect of Ethanol on Intracellular Respiration and Cerebral Function. In: Kissin, B., Begleiter, H. (eds) The Biology of Alcoholism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6525-3_3

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  • DOI: https://doi.org/10.1007/978-1-4615-6525-3_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6527-7

  • Online ISBN: 978-1-4615-6525-3

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