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The Metabolism of Alcohol in Normals and Alcoholics: Enzymes

  • Chapter
The Biology of Alcoholism

Abstract

The knowledge about the metabolism of ethanol and the participating enzymes offers, in several ways, a basis for a better understanding of biochemical processes involved in acute and chronic alcohol intoxication. The duration of the hepatotoxic and central nervous effects of alcohol clearly depends on the rate of its metabolic breakdown. Many effects of ethanol on intermediary metabolism are known to result from its oxidation to carbon dioxide and water with the consequent process of the handling of a large excess of hydrogen derived from alcohol in the body. The recent discovery of an inducible microsomal ethanol oxidizing system offers possibilities for rationalizing alterations of the action of some drugs in alcoholics. Finally, it is conceivable that the addicting properties of alcohol are interrelated with its metabolic degradation by alcohol and aldehyde dehydrogenase.

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von Wartburg, J.P. (1971). The Metabolism of Alcohol in Normals and Alcoholics: Enzymes. In: Kissin, B., Begleiter, H. (eds) The Biology of Alcoholism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6525-3_2

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