Abstract
Ionizing radiation can be lethal to mammalian cells. For those cells which are irradiated and survive, irradiation can also be mutagenic or, in the case of cells in animal tissues, carcinogenic. The biological effects of ionizing radiation are generally believed to originate in free radical reactions. In particular, a radical competition model has been proposed to account for the “oxygen effect” on radiation lethality — the so-called “oxygen fixation” hypothesis (Figure 1) (1–5).
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Raleigh, J.A., Fuciarelli, A.F., Kulatunga, C.R. (1987). Potential Limitation to Hydrogen Atom Donation as a Mechanism of Repair in Chemical Models of Radiation Damage. In: Cerutti, P.A., Nygaard, O.F., Simic, M.G. (eds) Anticarcinogenesis and Radiation Protection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6462-1_5
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