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Nucleophiles as Anticarcinogens

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Anticarcinogenesis and Radiation Protection

Abstract

The objective of the present work was to obtain chemopreventive compounds that can trap direct-acting carcinogens within the lumen of the gastrointestinal tract and thus prevent these carcinogens from attacking tissues of the host. Many direct-acting carcinogens are electrophiles (19, 36). One possible strategy for blocking their action is by trapping them with nucleophiles (electron donors). In the studies to be presented, emphasis has been placed on trapping direct-acting carcinogens in two sites, i.e., the stomach and the large intestine. To some extent different considerations pertain for each.

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Authors and Affiliations

  1. Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, 55455, Minneapolis, Minnesota, USA

    Lee W. Wattenberg, J. Bradley Hochalter, Usha D. G. Prabhu & Arthur R. Galbraith

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  1. Lee W. Wattenberg
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  2. J. Bradley Hochalter
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  3. Usha D. G. Prabhu
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  4. Arthur R. Galbraith
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Editor information

Editors and Affiliations

  1. Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland

    Peter A. Cerutti

  2. Case Western Reserve University, Cleveland, Ohio, USA

    Oddvar F. Nygaard

  3. National Bureau of Standards, Gaithersburg, Maryland, USA

    Michael G. Simic

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© 1987 Plenum Press, New York

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Wattenberg, L.W., Hochalter, J.B., Prabhu, U.D.G., Galbraith, A.R. (1987). Nucleophiles as Anticarcinogens. In: Cerutti, P.A., Nygaard, O.F., Simic, M.G. (eds) Anticarcinogenesis and Radiation Protection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6462-1_36

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  • DOI: https://doi.org/10.1007/978-1-4615-6462-1_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6464-5

  • Online ISBN: 978-1-4615-6462-1

  • eBook Packages: Springer Book Archive

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