Abstract
The Mycoplasmas are very small, wall-less bacteria phylogenetically related to gram-positive Eubacteria such as Bacillus subtilis (see also Chapters 40 and 41). Mycoplasma capricolum is an example of one of the smallest of free-living organisms (Ryan and Morowitz, 1969) with a genome estimated to be between 724 kb (Poddar and Maniloff, 1989) and 1.1 megabases. As M. capricolum is a parasitic organism with a truncated metabolism and can be grown in a defined medium, much of its truncated physiology has been biochemically defined (Maniloff, 1992). The acquisition of the entire genome sequence of the organism will corroborate these classic biochemical studies and allow the complete elucidation and eventual modeling of its truncated metabolism. Furthermore, the comparative analysis of this metabolic network with larger metabolic networks from organisms such as Haemophilus influenzae would open the door to the unprecedented opportunity to begin to analyze the minimal set of fundamental genes involved in the process we call “life.” (see Chapter 37).
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Gillevet, P.M. et al. (1998). Mycoplasma capricolum Genome Project. In: de Bruijn, F.J., Lupski, J.R., Weinstock, G.M. (eds) Bacterial Genomes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6369-3_42
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DOI: https://doi.org/10.1007/978-1-4615-6369-3_42
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