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Adeno-Associated Virus and Other New DNA Virus Vectors

  • Chapter
Book cover Gene Transfer in the Cardiovascular System

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 189))

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Abstract

DNA virus vectors generally are less likely than retrovirus vectors to require host cell proliferation in order for vector DNA to be expressed [ 1 ]. This feature may expand their utility in post-mitotic cells such as cardiac myocytes. Among DNA virus vectors, adenovirus (Ad) and adeno-associated virus type 2 (AAV) have been most thoroughly studied. The natural history of human AAV infection has not been studied as completely as Ad infection, but AAV-based vectors may have advantages for certain gene therapy applications, due to their persistence and relatively low immunogenicity. AAV-based vectors may not share all of the properties of wild- type AAV, however, and this may have implications for the use of AAV vectors in humans. A thorough understanding of AAV biology is necessary in order to develop this vector system for therapeutic applications.

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Authors and Affiliations

  1. Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD, USA

    Terence R. Flotte & Sandra A. Afione

  2. Taussig Division of Pediatric Cardiology of Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Barry J. Byrne & B. Helen

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  1. Terence R. Flotte
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  2. Sandra A. Afione
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  3. Barry J. Byrne
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  4. B. Helen
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Editors and Affiliations

  1. Krannert Institute of Cardiology, Indiana University Medical Center, Indianapolis, Indiana, USA

    Keith L. March M.D., Ph.D.

  2. R. L. Roudebush VA Medical Center, Indianapolis, Indiana, USA

    Keith L. March M.D., Ph.D.

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Flotte, T.R., Afione, S.A., Byrne, B.J., Helen, B. (1997). Adeno-Associated Virus and Other New DNA Virus Vectors. In: March, K.L. (eds) Gene Transfer in the Cardiovascular System. Developments in Cardiovascular Medicine, vol 189. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6277-1_3

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  • DOI: https://doi.org/10.1007/978-1-4615-6277-1_3

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