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Adenovirus and the Myocardium

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Gene Transfer in the Cardiovascular System

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 189))

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Abstract

As described in previous chapters of this book, there has been increasing interest in the use of adenoviruses as a vector for delivering specific genes to the cardiovascular and pulmonary systems in vivo, and the functioning of some of these genes has been demonstrated[1–4]. The purpose of this chapter is to outline the effect adenoviruses have on the heart and lung, and the potential detrimental influences that components of the adenoviral genome could have on the myocardium and lung, thus limiting its usefulness in human gene therapy. This recognition suggests a thorough evaluation of these effects in planning trials directed to the cardiovascular system.

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Author information

Authors and Affiliations

  1. Associate Professor of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA

    Jeffrey A. Towbin M.D.

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  1. Jeffrey A. Towbin M.D.
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Editors and Affiliations

  1. Krannert Institute of Cardiology, Indiana University Medical Center, Indianapolis, Indiana, USA

    Keith L. March M.D., Ph.D.

  2. R. L. Roudebush VA Medical Center, Indianapolis, Indiana, USA

    Keith L. March M.D., Ph.D.

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© 1997 Springer Science+Business Media New York

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Towbin, J.A. (1997). Adenovirus and the Myocardium. In: March, K.L. (eds) Gene Transfer in the Cardiovascular System. Developments in Cardiovascular Medicine, vol 189. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6277-1_17

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  • DOI: https://doi.org/10.1007/978-1-4615-6277-1_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7881-5

  • Online ISBN: 978-1-4615-6277-1

  • eBook Packages: Springer Book Archive

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