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Skeletal Myoblast Therapy in Cardiovascular Disease

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Book cover Gene Transfer in the Cardiovascular System

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 189))

Abstract

Congestive heart failure (CHF) is now the leading discharge diagnosis for patients hospitalized in the United States and is a major human health problem. Although advances in medical therapy have improved survival rates and the quality of life for patients with CHF, definitive treatment is presently very limited, in large part due to an inability of the heart to repair itself through proliferation of reserve cells. Currently definitive therapeutic regimens for CHF include cardiac transplantation, which is limited by a shortage of donor subjects and a necessity for high-dose immunosuppression; and treatments such as cardiomyoplasty and extraventricular assist devices, which are limited by a lack of effectiveness in many patients. With the advent of gene transfer technology, new therapies for treating cardiovascular disease may become feasible. Our laboratory is developing two promising approaches to treat cardiovascular disease. The first involves introducing autologous, biopsy-derived skeletal muscle reserve cells (myoblasts) into the myocardium to augment contractile function (myoblast transfer therapy). The second utilizes myoblasts as a vector to deliver potentially therapeutic genes locally to the damaged myocardium (myoblast-mediated gene therapy). We will discuss the advantages that these approaches offer over current treatments for cardiovascular disease and other gene therapy techniques.

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Author information

Authors and Affiliations

  1. Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA

    Doris A. Taylor, Brian H. Annex & William E. Kraus

  2. Department of Pathology, Division of Molecular & Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA

    Sanford P. Bishop

  3. Department of Surgery, Duke University Medical Center, Durham, NC, USA

    Scott C. Silvestry

Authors
  1. Doris A. Taylor
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  2. Brian H. Annex
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  3. William E. Kraus
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  4. Sanford P. Bishop
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  5. Scott C. Silvestry
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Editor information

Editors and Affiliations

  1. Krannert Institute of Cardiology, Indiana University Medical Center, Indianapolis, Indiana, USA

    Keith L. March M.D., Ph.D.

  2. R. L. Roudebush VA Medical Center, Indianapolis, Indiana, USA

    Keith L. March M.D., Ph.D.

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© 1997 Springer Science+Business Media New York

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Taylor, D.A., Annex, B.H., Kraus, W.E., Bishop, S.P., Silvestry, S.C. (1997). Skeletal Myoblast Therapy in Cardiovascular Disease. In: March, K.L. (eds) Gene Transfer in the Cardiovascular System. Developments in Cardiovascular Medicine, vol 189. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6277-1_16

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  • DOI: https://doi.org/10.1007/978-1-4615-6277-1_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7881-5

  • Online ISBN: 978-1-4615-6277-1

  • eBook Packages: Springer Book Archive

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