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Chemical preconditioning: A cytoprotective strategy

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Detection of Mitochondrial Diseases

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 21))

Abstract

Brief ischemic or hypoxic episodes may increase or decrease tolerance towards subsequent severe ischemia in heart and brain. A similar phenomenon is observed after mild chemical inhibition of oxidative phosphorylation — chemical preconditioning. We have shown that chemical preconditioning can be induced by chemical inhibition of mitochondrial complex I and mito-chondrial complex II. With a time interval of three hours between chemical pretreatment and massive inhibition of oxidative phosphorylation, recovery of population spike amplitude in hippocampal region CA1 after stimulation of the Schaffer collaterals was 31 ± 9% in controls, 98 ± 14% after i.p. treatment with 1 mg/kg body weight haloperidol, an inhibitor of mitochondrial complex I and 90 ± 7% with pretreatment with 3-np, an inhibitor of mitochondrial complex II. Activation of ATP regulated potassium channels partakes in mediating the preconditioning effect. We conclude that chemical preconditioning is a practical prophylactic pharmacologic strategy to increase hypoxic tolerance. (Mol Cell Biochem 174: 249#x2013;254, 1997)

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Authors and Affiliations

  1. Department of Neurology, Humboldt University, Berlin, Germany

    Matthias W. Riepe & Albert C. Ludolph

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  1. Matthias W. Riepe
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  2. Albert C. Ludolph
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  1. Martin Luther Universität Halle-Wittenberg, Neurologische Klinik und Poliklinik, Halle / Saale, Germany

    Frank Norbert Gellerich  & Stephan Zierz  & 

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Riepe, M.W., Ludolph, A.C. (1997). Chemical preconditioning: A cytoprotective strategy. In: Gellerich, F.N., Zierz, S. (eds) Detection of Mitochondrial Diseases. Developments in Molecular and Cellular Biochemistry, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6111-8_39

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  • DOI: https://doi.org/10.1007/978-1-4615-6111-8_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7800-6

  • Online ISBN: 978-1-4615-6111-8

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