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Pharmacologic Perspectives of Remodeling Inhibition

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Arterial Remodeling: A Critical Factor in Restenosis

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 198))

Abstract

Vascular remodeling has now been recognized to be one of the central adaptive processes in atherosclerosis and restenosis (1). While the term has been used to describe a number of processes in the vessel wall, including hypertrophy and hyperplasia, it has been recently used to describe the geometric changes that occur with atherosclerosis and restenosis. These changes in vessel size can be both favorable, as seen with compensatory enlargement of the vessel, as well as unfavorable when vascular constriction occurs. Our understanding of the fundamental processes involved in the structural changes that result in a change in the geometry of the vessel remains rudimentary at this stage and thus, the terminology to describe these processes is likewise inadequate. For the purposes of this discussion we will use the term geometric remodeling rather than compensatory enlargement or constriction, since the later two processes are components of geometric remodeling.

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Authors and Affiliations

  1. Division of Cardiology, Department of Medecine, University of Southern California, Los Angeles, USA

    David P. Faxon M.D. & Jesse W. Currier M.D.

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  1. David P. Faxon M.D.
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  2. Jesse W. Currier M.D.
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Editors and Affiliations

  1. Necker University, Paris, France

    Antoine Lafont

  2. Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Eric J. Topol

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Faxon, D.P., Currier, J.W. (1997). Pharmacologic Perspectives of Remodeling Inhibition. In: Lafont, A., Topol, E.J. (eds) Arterial Remodeling: A Critical Factor in Restenosis. Developments in Cardiovascular Medicine, vol 198. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6079-1_25

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  • DOI: https://doi.org/10.1007/978-1-4615-6079-1_25

  • Publisher Name: Springer, Boston, MA

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