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Intimal Lesion Growth: An Assessment of Important Cellular Events

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Arterial Remodeling: A Critical Factor in Restenosis

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 198))

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Abstract

The theme of this book is vascular remodeling, and perhaps one reason why this concept is of current interest is because our knowledge of arterial lesion growth in experimental animals after angioplasty has not been predicative of the process of lesion growth in humans. In particular, agents found to be important in inhibiting lesions in small mammalian arteries after balloon injury have not been useful in predicting the outcomes in humans after angioplasty (1). One possibility, therefore, is that the growth of lesions in humans does not involve those cellular processes which occur in the rat artery. The role of this chapter is to try to point out some of the differences that may have been responsible for this belief and to highlight the key molecular events that are known to take place in lesion growth in our experimental models.

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Author information

Authors and Affiliations

  1. Department of Pathology, Vascular Biology, University of Washington, School of Medicine, Box 357335, Seattle, USA

    Michael A. Reidy

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  1. Michael A. Reidy
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Editors and Affiliations

  1. Necker University, Paris, France

    Antoine Lafont

  2. Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Eric J. Topol

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© 1997 Springer Science+Business Media New York

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Reidy, M.A. (1997). Intimal Lesion Growth: An Assessment of Important Cellular Events. In: Lafont, A., Topol, E.J. (eds) Arterial Remodeling: A Critical Factor in Restenosis. Developments in Cardiovascular Medicine, vol 198. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6079-1_17

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  • DOI: https://doi.org/10.1007/978-1-4615-6079-1_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7785-6

  • Online ISBN: 978-1-4615-6079-1

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