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Tubuloglomerular Feedback and Macula Densa-Derived NO

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Nitric Oxide and the Kidney

Abstract

Tubuloglomerular feedback (TGF) is an intrarenal regulatory mechanism that stabilizes the glomerular filtration rate (GFR) and distal delivery of NaC1 and fluid during periods in which homeostasis is challenged, such as changes in systemic blood pressure. The system acts at the single-nephron level primarily by increasing tone at the afferent arteriole, thus reducing glomerular capillary pressure (PGC), in response to increased delivery of NaC1 and fluid to the macula densa segment of the nephron. The macula densa is the site of signal transduction, where changes in solute delivery are sensed and initiation or release of vasoactive mediators occurs. TGF may also maintain homeostasis through regulation of sodium excretion, because increased delivery of sodium chloride to the macula densa activates TGF and decreases single-nephron GFR, thus adjusting the rate of sodium excretion.

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Authors
  1. William J. Welch
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  2. Christopher S. Wilcox
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Editor information

Editors and Affiliations

  1. Department of Medicine, State University of New York, Stony Brook, NY, USA

    Michael S. Goligorsky

  2. Department of Pharmacology, Cornell University Medical College, New York, NY, USA

    Steven S. Gross

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© 1997 Springer Science+Business Media Dordrecht

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Welch, W.J., Wilcox, C.S. (1997). Tubuloglomerular Feedback and Macula Densa-Derived NO. In: Goligorsky, M.S., Gross, S.S. (eds) Nitric Oxide and the Kidney. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6039-5_11

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  • DOI: https://doi.org/10.1007/978-1-4615-6039-5_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7768-9

  • Online ISBN: 978-1-4615-6039-5

  • eBook Packages: Springer Book Archive

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