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The Biological Chemistry of NO

  • Chapter
Nitric Oxide and the Kidney

Abstract

The most well-characterized biological function of nitric oxide (.NO) is the elevation of cyclic guanosine monophosphate (cGMP) levels by the activation of guanylyl cyclase [1-3]. Simplistically, this pathway involves diffusion of •NO from its site of synthesis to a target enzyme in an adjacent cell or tissue. In this respect, •NO is acting as a conventional paracrine messenger. However, the known chemistry of •NO suggests that this journey is not at all simple and that there is the potential for a plethora of side reactions to occur. The chemical reactions between •NO and other biological molecules impact not only on the efficiency of guanylyl cyclase activation but also contribute to the cytotoxic potential of activated immune cells. Moreover, if uncontrolled, •NO synthesis may be responsible for a variety of pathological processes.

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Authors
  1. Neil Hogg
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  2. Owen W. Griffith
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Editor information

Editors and Affiliations

  1. Department of Medicine, State University of New York, Stony Brook, NY, USA

    Michael S. Goligorsky

  2. Department of Pharmacology, Cornell University Medical College, New York, NY, USA

    Steven S. Gross

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© 1997 Springer Science+Business Media Dordrecht

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Hogg, N., Griffith, O.W. (1997). The Biological Chemistry of NO. In: Goligorsky, M.S., Gross, S.S. (eds) Nitric Oxide and the Kidney. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6039-5_1

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  • DOI: https://doi.org/10.1007/978-1-4615-6039-5_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7768-9

  • Online ISBN: 978-1-4615-6039-5

  • eBook Packages: Springer Book Archive

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