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Mechanisms of HSP-Mediated Protection from Ischemia-Induced Apoptosis

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Heat Shock Proteins and Cytoprotection

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Abstract

Apoptosis can be divided into the three following phases: induction (or triggering), transduction of signal, and execution (see refs. 1-3 for review). Theoretically, HSPs may modulate any of these apoptotic phases with the same final result, namely rescue of the cells. Below we consider what is presently known about ischemia-induced apoptosis and speculate how HSPs may affect its distinct phases.

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  1. Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk, Russia

    Alexander E. Kabakov Ph.D & Vladimir L. Gabai Ph.D

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  1. Alexander E. Kabakov Ph.D
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  2. Vladimir L. Gabai Ph.D
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Kabakov, A.E., Gabai, V.L. (1997). Mechanisms of HSP-Mediated Protection from Ischemia-Induced Apoptosis. In: Heat Shock Proteins and Cytoprotection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6007-4_8

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  • DOI: https://doi.org/10.1007/978-1-4615-6007-4_8

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