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Heat Shock Proteins and Cytoprotection pp 177–204Cite as

What Are the Mechanisms of Heat Shock Protein-Mediated Cytoprotection Under ATP Deprivation?

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Abstract

As was reviewed in chapters 4-6: first, transient ATP depletion induces heat shock gene expression and HSP synthesis; and, second, the elevated level of HSP(s) is associated with the protection of various mammalian cells from injury and death under metabolic (or ischemic) stress. Both conclusions were well-grounded and in fact we address here a special adaptive reaction which confers tolerance to energy starvation, thus allowing a cell to withstand sustained deprivation of dATP. Never theless, it is still poorly understood how excess HSP(s) compensates for ATP deficiency and maintains the viability of ATP-deprived cells. In this chapter, we present some speculations and hypotheses which might, at least in part, clarify this intriguing problem.

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  1. Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk, Russia

    Alexander E. Kabakov Ph.D & Vladimir L. Gabai Ph.D

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  1. Alexander E. Kabakov Ph.D
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Kabakov, A.E., Gabai, V.L. (1997). What Are the Mechanisms of Heat Shock Protein-Mediated Cytoprotection Under ATP Deprivation?. In: Heat Shock Proteins and Cytoprotection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6007-4_7

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  • DOI: https://doi.org/10.1007/978-1-4615-6007-4_7

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