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Translational Regulation of Bioiron

  • Chapter
Metal Ions in Gene Regulation

Part of the book series: Chapman & Hall Microbiology Series ((CHMBS))

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Abstract

Iron is central to respiration, photosynthesis, nitrogen fixation, and, in most organisms, the reduction of ribose to deoxyribose, rate limiting in DNA synthesis. Dioxygen, which allows high-efficiency bioenergetics, at the same time converts soluble ferrous ions to insoluble ferric ions; iron concentrations in cells are almost a trillion times the solubility of the free ferric ion under physiological conditions. Ferritin is the protein that concentrates ferric iron in all known organisms [reviewed in Theil (1987, 1990) Waldo and Theil (1996) Harrison and Lilley (1990)]. Induction of ferritin synthesis by iron also protects cells from oxidant stress (Balla et al. 1992). Gene regulation of ferritin synthesis is precise and complex and, in animals, is coordinately regulated with transferrin receptor (TfR) synthesis [reviewed in Theil (1990, 1993, 1994, 1997) Hentze and Kuhn (1996) Rouault and Klausner (1996) Klausner et al. (1993) Munro (1990)]. The problem of acquiring and concentrating iron is solved by the use of environmental iron to regulate expression of both iron-storage (ferritin) and iron-uptake (TfR) genes; changes in expression of ferritin and TfR are also regulated by growth factors and hormones and during cell differentiation.

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  1. Elizabeth C. Theil
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Theil, E.C. (1998). Translational Regulation of Bioiron. In: Silver, S., Walden, W. (eds) Metal Ions in Gene Regulation. Chapman & Hall Microbiology Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5993-1_6

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