Skip to main content
SpringerLink
Log in

Influence of Short Chain Fatty Acids on Intestinal Growth and Functions

  • Chapter
Dietary Fiber in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 427))

Abstract

Surface versus Volume Ratio of the Large Intestine. The enlargement of the large intestinal lumen expands the living space for bacteria. If the organ grows without modifying the shape by haustration or by other means, the surface/volume ratio should decrease by the growth of the organ. If we assume that microbial metabolism per unit volume of microbes is more-or-less homogenous, then the microbial metabolism per organ increases as a linear function of its volume. However, the absorptive surface, which increases only at 2/3 powers of the volume, cannot catch up with the increase in microbial metabolic rate per organ. Thus, there should be a theoretical limit where the rate of absorption for microbial products cannot meet with the rate of production. This should increase the lumen concentration of microbial products.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Benno Y, Nakao H, Uchida K, Mitsuoka T. Impact of the advances in age on the gastrointestinal microflora of beagle dogs. J Vet Med Sci 1992;54:703–706.

    Article  CAS  Google Scholar 

  2. Pell JD, Johnson IT, Goodlad RA. The effects of and interactions between fermentable dietary fiber and lipid in germfree and conventional mice. Gastroenterology 1995;108:1745–1752.

    Article  CAS  Google Scholar 

  3. Yajima T, Sakata T. Influences of short-chain fatty acids on the digestive organs. Bifidobacteria Microflora 1987;6:7–14.

    Google Scholar 

  4. Kornai M, Takehisa F, Kimura S. Effect of dietary fiber on intestinal epithelial cell kinetics of germfree and conventional mice. Nutritional Report International 1982;26:255–261.

    Google Scholar 

  5. Sakata T. Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in the rat intestine: a possible explanation for trophic effects of fermentable fibre, gut microbes and luminal tropic factors. Br J Nutr 1987;58:96–103.

    Google Scholar 

  6. Jane P, Carpentier Y, Willems G. Colonic mucosal atrophy induced by a liquid elemental diet in rats. American Journal of Digestive Diseases 1977;22:808–812.

    Article  Google Scholar 

  7. Koruda M, Rollanderi R, Settle R, Zimmaro D, Rombeau J. Effect of parenteral nutrition supplemented with short-chain fatty acids on adaptation to massive small bowel resection. Gastroenterology 1988;95:715–720.

    CAS  Google Scholar 

  8. Koruda M, Rollanderi R, Bliss D, Hastings J, Rombeau J, Settle R. Parenteral nutrition supplemented with short-chain fatty acids: effect on the small bowel mucosa in normal rats. Amarican Journal of Clinical Nutrition 1990;51:685–689.

    CAS  Google Scholar 

  9. Sakata T. Depression of intestinal epithelial cell production rate by hindgut bypass in rats. Scandinavian Journal of Gastroenterology 1988;23:1200–1202.

    Article  CAS  Google Scholar 

  10. Sakata T. Effects of indigestible dietary bulk and short chain fatty acids on the tissue weight and epithelial cell proliferation rate of the digestive tract in rats. J Nutr Sci Vitaminol 1986;32:355–362.

    Article  CAS  Google Scholar 

  11. Hoshi S. Nutritional and physiologiccal influences of indigestible saccharides on the digestible tract. Dissertation: Tohoku University, 1994.

    Google Scholar 

  12. Kissmeyer-Nielsen P, Mortensen F, Laurberg S, Hessov I. Transmural trophic effect of short chain fatty acid infusions on atrophic, defunctioned rat colon. Dis Colon Rectum 1995;38:946–951.

    Article  CAS  Google Scholar 

  13. Tamate H, McGilliard A, Jacobson N, Getty R, 1964. Effect of various diets on the histological development of the stomach in the calf. Tohoku J Agr Res 1964;14:171–93.

    Google Scholar 

  14. Tamate H, McGilliard A, Jacobson N, Getty R. Effect of various diets on the anatomical development of the stomach in the calf. J Dairy Sci 1962;45:408–20.

    Article  Google Scholar 

  15. Kripke S, Fox A, Berman J, DePaula J, Rombeau J. Stimulation of intestinal mucosal growth with intracolonic infusion of short chain fatty acids. JPEN 1988;13:109–116.

    Article  Google Scholar 

  16. Rollandelli R, Koruda M, Settle R, Rombeau.1. Effects of intraluminal infusion of short chain fatty accids on the healing of colonic anastomosis in the rat. Surgery 1986;100:198–203.

    Google Scholar 

  17. Clair WS, Osborn J. Crypt fission and crypt number in the small and large bowel of postnatal rats. Cell Tissue Kinet 1985;18:255–262.

    Google Scholar 

  18. Park H, Goodlad R, Wright N. Crypt fission in the small intestine and colon A mechanism for the emergence of G6PD locus-mutated crypts after treatment with mutagens. American Journal of Pathology 1995;147:1416–1427.

    CAS  Google Scholar 

  19. Kruh J, Defer N, Tichonicky L. Effects of butyrate on cell proliferation and gene expression. In: Cummings J, Rombeau J, Sakata T, eds. Physiological and clinical aspects of short-chain fatty acids. Cambridge: Cambridge University Press, 1995:275–288.

    Google Scholar 

  20. Ginsburg E, Salamon D, Sreevalsan T, Freese E. Growth inhibition and morphological changes caused by lipophilic acids in mammalian cells. Proc Nat Acad Sci USA 1973;70:2457–61.

    Article  CAS  Google Scholar 

  21. Young G, Gibson P. Butyrate and the human cancer cell. In: Cummings J, Rombeau J, Sakata T. eds. Physiological and clinical aspects of short-chain fatty acids. Cambridge: Cambridge University Press, 1995: 319–335.

    Google Scholar 

  22. Galfi P, Neogrady S, Sakata T. Effects of volatile fatty acids on the epithelial cell proliferation of the digestive tract and its hormonal mediation. in: Tsuda T, Sasaki Y, Kawashima R, eds. Physiological aspects of digestion and metabolism in ruminants. London: Academic Press, 1990:49–59.

    Google Scholar 

  23. Sakata T, Adachi M, Hashida M, Sato N, Kojima T. Effect of n-butyric acid on epithelial cell proliferation of pig colonic mucosa in short-term culture. Deutsche Tierärztliche Wochenschrift 1995;102:163–170.

    CAS  Google Scholar 

  24. Scheppach W, Bartram P, Richter A, et al. Effect of short-chain fatty acids on the human colonic mucosa in vitro. JPEN 1992;16:43–8.

    Article  CAS  Google Scholar 

  25. Sakata T, Engelhardt W. Stimulatory effect of short-chain fatty acids on the epithelial cell proliferation in rat large intestine. Comp Biochem Physiol 1983;A47:459–62.

    Article  Google Scholar 

  26. Sakata T. Effects of short-chain fatty acids on the proliferation of gut epithelial cells in vivo. In: Cummings J, Rombeau J, Sakata T, eds. Physiological and clinical aspects of short-chain fatty acids. Cambridge: Cambridge University Press, 1995:289–305.

    Google Scholar 

  27. Reilly K, Frankel W, Klurfeld D, D DC, Rombeau J. The parasympathetic (PSNS) and sympathetic (SNS) nervous system mediate the systemic effects of short chain fatty acids (SCFA) on jejunal structure and function. Surgical Forum 1993;XLIV:20–2.

    Google Scholar 

  28. Frankel W, W WZ, Singh A, et al. Mediation of the trophic effects of short-chain fatty acids on the rat jejunum and colon. Gastroenterology 1994;106:375–80.

    CAS  Google Scholar 

  29. Sakata T. Stimulatory effect of short-chain fatty acids on epithelial cell proliferation of isolated and denervated jejunal segment of the rat. Scand J Gastroenterol 1989;24:886–90.

    Article  CAS  Google Scholar 

  30. Reilly K, Frankel W, Bain A, Rombeau J. Colonic short chain fatty acids mediates jejunal growth by increasing gastrin. Gut 1995;37:81–86.

    Article  CAS  Google Scholar 

  31. Zhang J, Lupton J. Dietary fibers stimulate colonic cell proliferation by different mechanisms at different sites. Nutr Cancer 1994;22:267–276.

    Article  CAS  Google Scholar 

  32. Yajima T, Sakata T. Core and periphery concentration of short-chain fatty acids in luminal contents of the rat colon. Comparative Biochemistry and Physiology 1989; 103A:353–355.

    Google Scholar 

  33. Hague A, Manning A, Hanlon K, Hutschtscha L, Hart D, Paraskeva C. Sodium butyrate induces apotosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fiber in the prevention of large-bowel cancer. Int J Cancer 1993;55:498–505.

    Article  CAS  Google Scholar 

  34. Hague A, Paraskeva C. The short-chain fatty acid butyrate induces apoptosis in colorectal tumour cell lines. Eur J Cancer Prey 1995;4:359–364.

    Article  CAS  Google Scholar 

  35. Kvietys P, Granger D. Effect of volatile fatty acids on blood flow and oxygen uptake by the dog colon. Gastroenterology 1980;80:962–969.

    CAS  Google Scholar 

  36. Mortensen F, Nielsen H. In vivo and in vitro effects of short-chain fatty acids on intestinal blood circulation. In: Cummings J, Rombeau J, Sakata T, eds. Physiological and clinical aspects of short-chain fatty acids. Cambridge: Cambridge University Press, 1995:391–400.

    Google Scholar 

  37. Kelberman I, Cheetham B. Rosenthal J, Levine G. Effect of fiber and its fermentation on colonic adaptation after cecal resection in the rat. Journal of Parenteral and Enteral Nutrition 1995;19:100–106.

    Article  CAS  Google Scholar 

  38. Umesaki Y, Yajima T, Yokokura T, Mutai M. Effect of organic acid absorption on bicarbonate transport in rat colon. Pflügers Arch 1978;379:43–47.

    Article  Google Scholar 

  39. Bödeker D. Einfluß von kurzkettigen Fettsäuren auf den Ammoniaktransport durch die Colonschleimhaut von Pferden. l. Europäische Konferenz über die Ernährung des Pferdes, 1993:147–149.

    Google Scholar 

  40. Ohta A, Ohtsuki M, Baba S, Adachi S, Sakata T, Sakaguchi E. Increase in calcium and magnesium absorption from the colon and rectum of rats fed fructooligosaccharides. Journal of Nutrition 1995;125:2417–2424.

    CAS  Google Scholar 

  41. Trinidad TP, Wolever TMS, Thompson LU. Effect of acetate and propionate on calcium absorption from the rectum and distal colon of humans. Am J Clin Nutr 1996;63:574–578.

    CAS  Google Scholar 

  42. Sakata T, Engelhardt W. Luminal mucin in the large intestine of mice, rats and guinea pigs. Cell Tissue Res 1981;219:629–635.

    CAS  Google Scholar 

  43. Firmie I, Dwarakanath A, Taylor B, Rhodes J. Colonic mucin synthesis is increased by sodium butyrate. Gut 1995;336:93–99.

    Google Scholar 

  44. Sakata T, Setoyarna H. Local effect of short-chain fatty accids on the mucus release from the hindgut mucosa of rats (Ratios norvegicus). Comp Biochem Physiol 1995; 111A:429–432.

    Article  CAS  Google Scholar 

  45. Yajima T. Sensory mechanism for short-chain fatty acids in the colon. In: Cummings J, Rombeau J. Sakata T,eds. Physiological and clinical aspects of short-chain fatty acids. Cambridge: Cambridge University Press, 1995:209–221.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Basic Sciences, Ishinomaki Senshu University, 986-80, Ishinomaki, Japan

    Takashi Sakata

Authors
  1. Takashi Sakata
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Wistar Institute, Philadelphia, Pennsylvania, USA

    David Kritchevsky

  2. Clinical Review Associates, McLean, Virginia, USA

    Charles Bonfield

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media New York

About this chapter

Cite this chapter

Sakata, T. (1997). Influence of Short Chain Fatty Acids on Intestinal Growth and Functions. In: Kritchevsky, D., Bonfield, C. (eds) Dietary Fiber in Health and Disease. Advances in Experimental Medicine and Biology, vol 427. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5967-2_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-5967-2_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7735-1

  • Online ISBN: 978-1-4615-5967-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation