Abstract
Theoretical simulations were performed to study the interplay between membrane ionic currents and gap-junction coupling in determining cardiac conduction. Results demonstrate that a much slower conduction velocity can be achieved with reduced gapjunction coupling than with reduced membrane excitability. Also, uniform reduction in intercellular coupling increases spatial asymmetries of excitability and, consequently, the vulnerability to unidirectional block.
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© 1997 Springer Science+Business Media New York
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Rudy, Y., Shaw, R.M. (1997). Cardiac Excitation: An Interactive Process of Ion Channels and Gap Junctions. In: Sideman, S., Beyar, R. (eds) Analytical and Quantitative Cardiology. Advances in Experimental Medicine and Biology, vol 430. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5959-7_23
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DOI: https://doi.org/10.1007/978-1-4615-5959-7_23
Publisher Name: Springer, Boston, MA
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