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How Cardiac Contraction Affects the Coronary Vasculature

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Analytical and Quantitative Cardiology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 430))

Abstract

We modeled the influence of cardiac contraction on maximally dilated coronary blood vessels, whether single or in juxtaposition, taking into account the nonlinear material properties of both the vascular wall and the myocardium. We calculated pressure-area relations of single, embedded coronary blood vessels, and used these relations to calculate diastolic and systolic coronary pressure-flow relations in a model of the coronary vasculature. The model shows that the change in myocardial material properties during contraction can explain the decrease in coronary vessel area and coronary flow generally observed in experiments. The model also shows that arterioles can be protected from the compressive action of the cardiac muscle by the presence of accompanying venules, which is favorable for coronary blood flow.

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Author information

Authors and Affiliations

  1. Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), Van der Boechorst straat 7, 1081 BT, Amsterdam, The Netherlands

    Martijn A. Vis

Authors
  1. Nicolaas Westerhof
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  2. Pieter Sipkema
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  3. Martijn A. Vis
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Editor information

Editors and Affiliations

  1. The Julius Silver Institute, Technion–Israel Institute of Technology, Haifa, Israel

    Samuel Sideman  & Rafael Beyar  & 

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© 1997 Springer Science+Business Media New York

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Westerhof, N., Sipkema, P., Vis, M.A. (1997). How Cardiac Contraction Affects the Coronary Vasculature. In: Sideman, S., Beyar, R. (eds) Analytical and Quantitative Cardiology. Advances in Experimental Medicine and Biology, vol 430. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5959-7_10

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  • DOI: https://doi.org/10.1007/978-1-4615-5959-7_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7731-3

  • Online ISBN: 978-1-4615-5959-7

  • eBook Packages: Springer Book Archive

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