Skip to main content
SpringerLink
Log in

Role of Ecto-ATPase in Lymphocyte Function

  • Chapter
Ecto-ATPases

Abstract

Extracellular nucleotides are now recognized as mediators of immune and non-immune cell function. The effects of extracellular nucleotides also vary with tissue. For example, extracellular ATP in micromolar concentrations can form pores in cell membranes, resulting in osmotic changes that are detrimental to the cell1. In bone marrow and thymocytes, extracellular ATP stimulates DNA synthesis, but it inhibits DNA synthesis in spleen, lymph nodes and peripheral blood lymphocytes2. The nucleotide also has cytostatic and cytotoxic effects on some tumor cells3, but the mechanism is unknown. In addition, ATP triggers histamine secretion from mast cells4–6 and the secretion of granules from neutrophils and monocytes7, 8, but inhibits macrophage-9, 10, NK cell-11–13 mediated cytotoxicities. Furthermore, extracellular ATP may serve as a substrate for ectoprotein kinases14 which have been identified on neutrophils13, erythrocytes16, neuronal cells17 and fibroblasts18.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. J.L. Gordon, 1990, The effects of ATP on endothelium, Ann. N.Y. Acad. Sei. 603: 46–52.

    Article  CAS  Google Scholar 

  2. S. Ikehara, R.N. Pahwa, D.C. Lunzer, R.A. Good, and M.J. Modak, 1981, Adenosine-5′-triphosphate-(ATP) mediated stimulation and suppression of DNA synthesis in lymphoid cells. I. Characterization of ATP responsive cells in mouse lymphoid organs, J. Immunol. 127: 1834–1838.

    PubMed  CAS  Google Scholar 

  3. E. Rapaport, 1990, Mechanisms of anticancer activities of adenine nucleotides in tumor-bearing hosts, Ann. N Y. Acad. Sci. 603: 142–150.

    Article  PubMed  CAS  Google Scholar 

  4. B. Diamant and P.C. Kruger, 1967, Histamine release form isolated rat peritoneal mast cells induced by adenosine-5′-tri phosphate, Acta Physiol. Scand. 21: 291–295.

    Article  Google Scholar 

  5. S. Cockcroft and B.D. Gomperts, 1979, Activation and inhibition of calcium-dependent histamine secretion by ATP ions applied to rat mast cells, J. Physiol. 296: 229–243.

    PubMed  CAS  Google Scholar 

  6. S. Cockcroft and B.D. Gomperts, 1979, ATP induces nucleotide permeability in rat mast cells. Nature, 279: 541–542.

    Article  PubMed  CAS  Google Scholar 

  7. G.R. Dubyak, D.S. Cowan, and L.M. Meuller, 1988, Activation of inositol phospholipid breakdown in HL60 cells by P2-purinergic receptors for extracellular ATP. Evidence for mediation by both pertussis toxin-sensitive and pertussis-insensitive mechanisms, J. Biol. Chem. 263: 18108–18117.

    PubMed  CAS  Google Scholar 

  8. S. Cockcroft and J. Stutchfield, 1980, ATP stimulates secretion in human neutrophils and HL60 cells via a pertussis toxin-sensitive guanine-nucleotide-binding protein coupled to phospholipase C, FEBS Lett. 245: 25–29.

    Article  Google Scholar 

  9. D.J. Cameron, 1984, Inhibition of macrophage mediated cytotoxicity by exogenous adenosine 5′-triphos-phatase, J. Clin. Lab. Immunol. 15: 215–218.

    PubMed  CAS  Google Scholar 

  10. D.K. Blanchard, S. McMillen and J.Y. Djeu, 1991, IFN-γ enhances sensitivity of human macrophages to extracellular ATP-mediated lysis, J. Immunol. 147: 579–2585.

    Google Scholar 

  11. K.E. Dombrowski, J.C. Cone, J.M. Bjorndahl and C.A. Phillips, 1995, Irreversible inhibition of human natural killer cell natural cytotoxicity by modification of the extracellular membrane by the adenine nucleotide analogue 5′-p-(fluorosulfonyl)benzoyl adenosine, Cell. Immunol. 160: 199–204.

    Article  PubMed  CAS  Google Scholar 

  12. T. Henriksson, 1983, Inhibition of natural killing by adenosine ribonucleotides, Immunol. Lett. 7: 171–176.

    Article  PubMed  CAS  Google Scholar 

  13. A. Schmidt, J.R. Ortaldo and R.B. Herberman, 1984, Inhibition of human natural killer cell reactivity by exogenous adenosine 5′-triphosphate, J. Immunol. 132: 146–150.

    PubMed  CAS  Google Scholar 

  14. V. Kinzel, D. Kubier, E. Burow, E. Pyerin and W. Pyerin, 1986, Detection and biochemistry of cell surface protein kinase in: Cellular Biology of EctoEnzymes (G. W. Kreutzberg, M. Reddington and H. Zimmerman, eds.) pp. 179–190, Springer, Berlin.

    Chapter  Google Scholar 

  15. K.E. Dusenbery, J.R. Mendiola and K.M. Skubitz, 1988, Evidence for ecto-protein kinase activity on the surface of human neutrophils, Biochem. Biophys. Res. Commun. 153: 7–13.

    Article  PubMed  CAS  Google Scholar 

  16. D. Kubler, W. Pyerin, M. Fehst and V. Kinzel, 1986, Physiological aspects of surface protein kinase activity in: Cellular Biology of EctoEnzymes (G. W. Kreutzberg, M. Reddington and H. Zimmerman, eds.) pp. 191–204, Springer, Berlin.

    Chapter  Google Scholar 

  17. Y.H. Ehrlich, M.V. Hogan, Z. Pawlowska, U. Naik and E. Kornecki, 1990, Ectoprotein Kinase in the Regulation of Cellular Responsiveness to Extracellular ATP, Ann. N. Y. Acad. Sci. 603: 401–416.

    Article  PubMed  CAS  Google Scholar 

  18. I. Friedberg, I. Beizer, O. Oged-Plesz and D. Kuebler, 1995, Activation of cell growth inhibitor by ectoprotein kinase-mediated phosphorylation in transformed mouse fibroblasts, J. Biol. Chem. 270: 20560–20567.

    Article  PubMed  CAS  Google Scholar 

  19. J. Lüthje, 1989, Origin, metabolism and function of extracellular adenine nucleotides in the blood, Klin. Wochenschr. 67: 317–327.

    Article  PubMed  Google Scholar 

  20. G. Burnstock, 1990, Overview: Purinergic mechanisms, Ann. N. Y Acad. Sci. 603: 1–18.

    Article  PubMed  CAS  Google Scholar 

  21. B.B. Fredholm, M.P. Abbracchio, G. Bumstock, J.W. Daly, T.K. Harden, K.A. Jacobson, P. Leff and M. Williams, 1994, Nomenclature and classification of purinoceptors, Pharm. Reviews 46: 143–156.

    CAS  Google Scholar 

  22. F.D.L. Moodie, H. Baum, P.J. Buttersworth and T.J. Peters, 1991, Purification and characterization of bovine spleen ADPase, Eur. J. Biochem. 202: 1209–1215.

    Article  PubMed  CAS  Google Scholar 

  23. L. Plesner, 1995, Ecto-ATPases: Identities and functions, Internat. Rev. Cytol. 158: 141–214.

    Article  CAS  Google Scholar 

  24. K.E. Dombrowski, Y. Ke, L.F. Thompson and J.A. Kapp, 1995, Antigen recognition by CTL is dependent upon ectoATPase activity, J. Immunol. 154: 6227–6237.

    PubMed  CAS  Google Scholar 

  25. A. Bajpai and Z. Brahmi, 1993, Regulation of resting and IL-2-activated human cytotoxic lymphocytes by exogenous nucleotides: Role of IL-2 and ecto-ATPases, Cell. Immunol. 148: 130–143.

    Article  PubMed  CAS  Google Scholar 

  26. A. Fillipini, R.E. Tafts, T. Agui and M.V. Sitkovsky, 1990, Ecto-ATPase activity in cytolytic T-lymphocytes: Protection from the cytolytic effects of extracellular ATP, J. Biol. Chem. 265: 334–340.

    Google Scholar 

  27. Y. Ke, K.E. Dombrowski and J.A. Kapp, manuscript in preparation.

    Google Scholar 

  28. J. Barankiewicz, M. Hui, A. Cohen and H.-M. Dosch, 1989, Differential expression of ecto-nucleotide metabolic enzymes during immunoglobulin gene rearrangements in human pre-B-cells, Adv. Exp. Med. Biol. 253B:455–461.

    Article  PubMed  CAS  Google Scholar 

  29. J. Barankiewicz, H.-M. Dosch, R. Cheung and A. Cohen, 1989, Relationship between extracellular and intracellular nucleotide metabolism in human lymphocytes, Adv. Exp. Med. Biol. 253B: 475–479.

    Article  PubMed  CAS  Google Scholar 

  30. K.E. Dombrowski, K.A. Brewer, J.R. Maleckar, T.L. Kirley, J.W. Thomas and and J.A. Kapp, manuscript in preparation.

    Google Scholar 

  31. K.E. Dombrowski, J.M. Trevillyan, J.C. Cone, Y. Lu and C.A. Phillips, 1993, Identification and partial characterization of an ectoATPase expressed by human natural killer cells, Biochemistry, 32: 6515–6522.

    Article  PubMed  CAS  Google Scholar 

  32. K. Kragballe and J. Ellegaard, 1978, ATPase activity of purified human normal T-and B-lymphocytes, Scand. J. Haematol. 20: 271–279.

    Article  PubMed  CAS  Google Scholar 

  33. J. Barankiewicz and A. Cohen, 1990, Extracellular ATP metabolism in B and T lymphocytes, Ann. N. Y. Acad. Sci. 603: 380–393.

    Article  PubMed  CAS  Google Scholar 

  34. J.W. DePierre and M.L. Karnovsky, 1974, Ecto-enzymes of the guinea pig polymorphonuclear leukocyte. I. Evidence for an ecto-adenosine monophosphatase,-adenosine triphosphatase, and-p-nitrophenyl phosphatase, J. Biol. Chem. 249: 7111–7120.

    PubMed  CAS  Google Scholar 

  35. J.W. DePierre and M.L. Karnovsky, 1974, Ecto-enzymes of the guinea pig polymorphonuclear leukocyte. II. Properties and suitability as markers for the plasma membrane, J. Biol. Chem. 249: 7121–7129.

    PubMed  CAS  Google Scholar 

  36. L.D. Christensen and V. Andersen, 1992, Natural killer cells lack ecto-5′-nucleotidase, Nat. Immun. 11:1–6.

    PubMed  CAS  Google Scholar 

  37. T.H. Steinberg, H.P. Buisman, S. Greenberg, F. DiVirgilio and S.C. Silverstein, 1990, Effects of extracellular ATP on mononuclear phagocytes, Ann. N. Y. Acad. Sci. 603: 120–129.

    Article  PubMed  CAS  Google Scholar 

  38. S.-H. Lin, 1985, The rat liver plasma membrane high affinity (Ca2+-Mg2+)-ATPase is not a calcium pump: Comparison with ATP-dependent calcium transporter, J. Biol. Chem. 260: 10976–10980.

    PubMed  CAS  Google Scholar 

  39. S.-H. Lin and J.R. Fain, 1984, Purification of (Ca2+-Mg2+)-ATPase from rat liver plasma membranes, J. Biol. Chem. 259: 3016–3020.

    PubMed  CAS  Google Scholar 

  40. J.G. Stout, R.S. Strobel and and T.L. Kirley, 1995, Properties of and proteins associated with the extracellular ATPase of chicken gizzard smooth muscle, J. Biol. Chem. 270: 11845–11850.

    Article  PubMed  CAS  Google Scholar 

  41. J.G. Stout and T.L. Kirley, 1996, Control of cell membrane ecto-ATPase by oligomerization state: Intermolecular cross-linking modulates ATPase activity, Biochemistry 35: 8289–8298.

    Article  PubMed  CAS  Google Scholar 

  42. J.S. Bennett, R.F. Colman and R.W. Colman, 1978, Identification of adenine nucleotide binding proteins in human platelet membranes by affinity labeling with 5′-p-fluorosulfonylbenzoyl adenosine, J. Biol. Chem. 253: 7346–7354.

    PubMed  CAS  Google Scholar 

  43. J. Schrader, R.M. Berne and R. Rubio, 1972, Uptake and metabolism of adenosine by human erythrocytes ghosts, Am. J. Physiol. 223: 159–166.

    PubMed  CAS  Google Scholar 

  44. M. Che, T. Nishida, Z. Gatmaitan and I.M. Arias, 1992, A nucleoside transporter is functionally linked to ectonucleotidases in rat liver canalicular membrane, J. Biol. Chem. 267: 9684-9688.

    PubMed  CAS  Google Scholar 

  45. K.E. Dombrowski, J.C. Cone and C.A. Phillips, 1993, Nat. Immun. 11: 290–291.

    Google Scholar 

  46. J.S. Fedan and S.J. Lamport, 1990, P2-purinoeeptor antagonists, Ann. N. Y. Acad. Sci. 603: 182–197.

    Article  PubMed  CAS  Google Scholar 

  47. K.E. Dombrowski, J.M. Bjorndahl, J.C. Cone and C.A. Phillips, 1995, manuscript under revision.

    Google Scholar 

  48. J. Lin, R. Krishnarahj and R.G. Kemp, 1985, Exogenous ATP enhances calcium influx in intact thymocytes, J. Immunol. 135: 3403–3410.

    PubMed  CAS  Google Scholar 

  49. P. Gerwins and B.B. Fredholm, 1992, ATP and its metabolite adenosine act synergistically to mobilize intracellular calcium via the formation of inositol 1,4,5-triphosphate in a smooth muscle cell line, J. Biol. Chem. 267: 16081–16087.

    PubMed  CAS  Google Scholar 

  50. K.E. Dombrowski, K.A. Brewer, Y. Ke and J.A. Kapp, manuscript in preparation.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Veterans Affairs Medical Center and Department of Internal Medicine, Texas Tech University Health Sciences Center, Amarillo, Texas, 79106, USA

    Kenneth E. Dombrowski

  2. Winship Cancer Center and Department of Pathology, Emory University, Atlanta, Georgia, 30322, USA

    Yong Ke & Judith A. Kapp

Authors
  1. Kenneth E. Dombrowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yong Ke
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Judith A. Kapp
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Aarhus, Aarhus C, Denmark

    Liselotte Plesner

  2. University of Cincinnati, Cincinnati, Ohio, USA

    Terence L. Kirley

  3. University of California, Los Angeles, California, USA

    Aileen F. Knowles

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media New York

About this chapter

Cite this chapter

Dombrowski, K.E., Ke, Y., Kapp, J.A. (1997). Role of Ecto-ATPase in Lymphocyte Function. In: Plesner, L., Kirley, T.L., Knowles, A.F. (eds) Ecto-ATPases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5955-9_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-5955-9_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7729-0

  • Online ISBN: 978-1-4615-5955-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation