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Human Tumor ECTO-ATPases

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Abstract

When normal cells are transformed into tumor cells, numerous alterations occur on the cell membrane. These include increased transport of nutrients, changes of protein and lipid composition, greater agglutinability by lectins, decreased intercellular cell adhesion, and altered activities of receptors and cell surface enzymes1, 2. Studies of a plasma membrane ATPase in normal and tumor tissues began nearly forty years ago, first by cytochemical staining3 and later by biochemical determination4. While the ATPase activity was compromised by the necessary use of glutaraldehyde and lead in the cytochemical staining procedure, the method was widely used in localizing and quantifying the cell-surface ATPase, i.e. ecto-ATPase.

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Author information

Authors and Affiliations

  1. Department of Biology, Northeastern University, Boston, Massachusetts, USA

    Aileen F. Knowles

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  1. Aileen F. Knowles
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Editors and Affiliations

  1. University of Aarhus, Aarhus C, Denmark

    Liselotte Plesner

  2. University of Cincinnati, Cincinnati, Ohio, USA

    Terence L. Kirley

  3. University of California, Los Angeles, California, USA

    Aileen F. Knowles

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© 1997 Springer Science+Business Media New York

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Knowles, A.F. (1997). Human Tumor ECTO-ATPases. In: Plesner, L., Kirley, T.L., Knowles, A.F. (eds) Ecto-ATPases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5955-9_14

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  • DOI: https://doi.org/10.1007/978-1-4615-5955-9_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7729-0

  • Online ISBN: 978-1-4615-5955-9

  • eBook Packages: Springer Book Archive

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