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Chronic Fatigue Syndrome: Possible Integration of Hormonal and Immunological Observations

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Abstract

The editors of this book organized a meeting about an unusual syndrome—chronic fatigue syndrome (CFS). They also applied an unusual approach to the meeting by inviting us to give the “keynote conclusions”. Although we have experience in both basic and clinical research ranging from peptide hormones to cytokines, we have no experience with CFS.

JMM is a Visiting Endocrinologist from Curry Cabrai Hospital, Lisbon, Portugal.

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References

  • Abbey, S.E. & Garfinkel, P.E. (1991). Neurasthenia and chronic fatigue syndrome: the role of culture in the making of a diagnosis. American Journal of Psychiatry, 148, 1638–1646.

    PubMed  CAS  Google Scholar 

  • Adell, A., Garcia-Marquez, C., Armario, A., & Gelpi, E. (1988). Chronic stress increases serotonin and noradrenaline in rat brain and sensitizes their responses to a further acute stress. Journal of Neuro-chemistry, 50, 1678–1681.

    CAS  Google Scholar 

  • Altay, H.T., Toner, B.B., Brooker, H., Abbey, S.E., Salit, I.E., & Garfinkel, P.E. (1990). The neuropsychological dimensions of postinfectious neuromy asthenia (chronic fatigue syndrome): a preliminary report. International Journal of Psychiatry in Medicine, 20, 141–149.

    Article  PubMed  CAS  Google Scholar 

  • Aubry, J.-M., Bartanusz, V., Driscoll, P., Schulz, P., Steimer, T., & Kiss, J.Z. (1995). Corticotropin-releasing factor and vasorpessin mRNA levels in roman high-and low-avoidance rats: response to openfield exposure. Neuroendocrinology, 61, 89–97.

    Article  PubMed  CAS  Google Scholar 

  • Bagdy, G. & Makara, G.B. (1994). Hypothalamic paraventricular nucleus lesions differentially affect serotonin-1A (5-HT1A) and 5-HT2 receptor agonist-induced oxytocin, prolactin, and corticosterone responses. Endocrinology, 134, 1127–1131.

    Article  PubMed  CAS  Google Scholar 

  • Bakheit, A.M.O., Behan, P.O., Dinan, T.G., Gray, C.E., & O’Keane, V. (1992). Possible upregulation of hypothalamic 5-hydroxytryptamine receptors in patients with postviral fatigue syndrome. British Medical Journal, 304, 1010–1012.

    Article  PubMed  CAS  Google Scholar 

  • Bakheit, A.M.O., Behan, P.O., Watson, W.S., & Morton, J.J. (1993). Abnormal arginine-vasopressin secretion and water metabolism in patients with postviral fatigue syndrome. ACTA Neurologica Scandinavica, 87(3), 234–238.

    Article  PubMed  CAS  Google Scholar 

  • Banks, W.A. & Kastin, A.J. (1992). The interleukins-lα,-Iβ, and-2 do not acutely disrupt the murine blood-brain barrier. International Journal of Immunopharmacology, 14, 629–636.

    Article  PubMed  CAS  Google Scholar 

  • Banks, W.A. & Kastin, A.J. (1996). Reversible association of the cytokines MlP-lα and MIP-lβ with the endothelia of the blood-brain barrier. Neuroscience Letters, 205, 202–206.

    Article  PubMed  CAS  Google Scholar 

  • Banks, W.A., Kastin, A.J., & Gutierrez, E.G. (1994). Penetration of interleukin-6 across the murine blood-brain barrier. Neuroscience Letters, 179, 53–56.

    Article  PubMed  CAS  Google Scholar 

  • Banks, W.A., Ortiz, L., Plotkin, S.R., & Kastin, A.J. (1991). Human interleukin (IL) lα, murine IL-lα and murine IL-β are transported from blood to brain in the mouse by a saturable mechanism. Journal of Pharmacology and Experimental Therapeutics, 259, 988–996.

    PubMed  CAS  Google Scholar 

  • Banks, W.A., Plotkin, S.R., & Kastin, A.J. (1995). Permeability of the blood-brain barrier to soluble cytokine receptors. Neuroimmuno-modulation, 2, 161–165.

    Article  CAS  Google Scholar 

  • Banks, W.A., Kastin, A.J., & Ehrensing, C.A. (1994). Blood-borne inter-leukin-lα is transported across the endothelial blood-spinal cord barrier of mice. Journal of Physiology, 479.2, 257–264.

    Google Scholar 

  • Banks, W.A., Kastin, A.J., & Gutierrez, E.G. (1993). Interleukin-lα in blood has direct access to cortical brain cells. Neuroscience Letters, 163, 41–44.

    Article  PubMed  CAS  Google Scholar 

  • Barrera, C.M., Banks, W.A., Fasold, M.B., & Kastin, A.J. (1991). Effects of various reproductive hormones on the penetration of LHRH across the blood-brain barrier. Pharmacology, Biochemistry and Behavior, 41, 255–257.

    Article  Google Scholar 

  • Blomstrand, E., Perrett, D., Parry-Billings, M., & Newsholme, E.A. (1989). Effect of sustained exercise on plasma amino acid concentrations and on 5-hydroxytryptamine metabolism in six different brain regions in the rat. ACTA Physiologica Scandinavia, 136, 473–481.

    Article  CAS  Google Scholar 

  • Buchwald, D., Cheney, P.R., Peterson, D.L., Henry, B., Wormsley, S.B., Geiger, A., Ablashi, D.V., Salahuddin, S.Z., Saxinger, C., Biddle, R., Kikinis, R., Jolesz, F.A., Folks, T., Balachandran, N., Peter, J.B., Gallo, R.C., & Komaroff, A.L. (1992). A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection. Annals of Internal Medicine, 116, 103–113.

    PubMed  CAS  Google Scholar 

  • Buchwald, D. & Komaroff, A.L. (1991). Review of laboratory findings for patients with chronic fatigue syndrome. Reviews of Infectious Diseases, 13(Suppl 1), S12–8.

    Article  PubMed  Google Scholar 

  • Calogero, A.E., Bernardini, R., Margioris, A.N., Gallucci, W.T., Munson, P.J., Tamarkin, L., Tomai, T.P., Brady, L., Gold, P.W., & Chrousos, G.P. (1989). Effects of serotonergic agonists andantagonists on corticotropin-releasing hormone secretion by explanted rat hypothalami. Peptides, 10, 189–200.

    Article  PubMed  CAS  Google Scholar 

  • Calogero, A.E., Gallucci, W.T., Gold, P.W., & Chrousos, G.P. (1988). Multiple feedback regulatory loops upon rat hypothalamic corticotropin-releasing hormone secretion. Journal of Clinical Investigation, 82, 767–774.

    Article  PubMed  CAS  Google Scholar 

  • Chao, C.C., Janoff, E.N., Hu, S., Thomas, K., Gallagher, M., Tsang, M., & Peterson, P.K. (1991). Altered cytokine release in peripheral blood mononuclear cell cultures from patients with chronic fatigue syndrome. Cytokine, 3, 292–298.

    Article  PubMed  CAS  Google Scholar 

  • Chappell, P.B., Smith, M.A., Kilts, C.D., Bissette, G., Ritchie, J., Anderson, C., & Nemeroff, C.B. (1986). Alterations in corticotropin-re-leasing factor-like immunoreactivity in discrete rat brain regions after acute and chronic stress. Journal of Neuroscience, 6, 2908–2914.

    PubMed  CAS  Google Scholar 

  • Cleare, A.J., Beam, J., Allain, T., McGregor, A., Wesseley, S., Murray, R.M., & O’Keane, V. (1995). Contrasting neuroendocrine responses in depression and chronic fatigue syndrome. Journal of Affective Disorders, 34, 283–289.

    Article  PubMed  CAS  Google Scholar 

  • Cotton, P. (1991). Treatment proposed for chronic fatigue syndrome; research continues to compile data on disorder. Journal of the American Medical Association, 266, 2667–2668.

    Article  PubMed  CAS  Google Scholar 

  • Dallman, M.F. (1993). Stress update: adaptation of the hypothalmie-pi-tuitary-adrenal axis to chronic stress. Trends in Endocrinology and Metabolism, 4, 62–69.

    Article  PubMed  CAS  Google Scholar 

  • De Goeij, D.C.E., Binnekade, R., & Tilders, F.J.H. (1992). Chronic stress enhances vasopressin but not corticotropin-releasing factor secretion during hypoglycemia. American Journal of Physiology, 263, E394–E399.

    PubMed  Google Scholar 

  • DeFreitas, E., Hilliard, B., Cheney, P.R., Bell, D.S., Kiggundi, E., Sankey, D., Wroblewska, Z., Palladino, M., Woodward, J.P., & Koprowski, H. (1991). Retroviral sequences related to human t-lym-photropic virus type II in patients with chronic fatigue immune dysfunction syndrome. Proceedings of the National Academy of Sciences of the United States of America, 88, 2922–2926.

    CAS  Google Scholar 

  • Deluca, J., Johnson, S.K., & Natelson, B.H. (1994). Neuropsychiatric status of patients with chronic fatigue syndrome: an overview. Toxicology and Industrial Health, 10, 513–522.

    PubMed  CAS  Google Scholar 

  • Demitrack, M.A., Dale, J.K., Straus, S.E., Laue, L., Listwak, S.J., Kruesi, M.J.P., Chrousos, G.P., & Gold, P.W. (1991). Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome. Journal of Clinical Endocrinology and Metabolism, 73, 1224–1234.

    Article  PubMed  CAS  Google Scholar 

  • Demitrack, M.A., Gold, P.W., Dale, J.K., Krahn, D.D., Kling, M.A., & Straus, S.E. (1992). Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings. Biological Psychiatry, 32, 1065–1077.

    Article  PubMed  CAS  Google Scholar 

  • Demitrack, M.A. (1994). Chronic fatigue syndrome: a disease of the hypothalamic-pituitary-adrenal axis? Annals of Medicine, 26, 1–5.

    Article  PubMed  CAS  Google Scholar 

  • Feldman, S., Conforti, N., & Melamed, E. (1987). Paraventricular nucleus serotonin mediates neurally stimulated adrenocortical secretion. Brain Research Bulletin, 18, 165–168.

    Article  PubMed  CAS  Google Scholar 

  • Flier, J.S. & Underhill, L.H.(1995). The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. Seminars in Medicine of the Beth Israel Hospital, Boston, 332, 1351–1362.

    Google Scholar 

  • Folks, T.M., Heneine, W., Khan, A., Woods, T., Chapman, L., & Schonberger, L. (1993). Investigation of retroviral involvement in chronic fatigue syndrome. Ciba Foundation Symposium, 173, 160–175.

    CAS  Google Scholar 

  • Fukuda, K., Straus, S.E., Hickie, I., Sharpe, M.C., Dobbins, J.G., Komaroff, A., & International Chronic Fatigue Syndrome Study Group, (1994). The chronic fatigue syndrome: a comprehensive approach to its definition and study. Annals of Internal Medicine, 121, 953–957.

    PubMed  CAS  Google Scholar 

  • Fukuda, K. & Gantz, N.M. (1995). Management strategies for chronic fatigue syndrome. Federal Practitioner

    Google Scholar 

  • Gold, D., Bowden, R., Sixbey, J., Riggs, R., Katon, W.J., Ashley, R., Obrigewitch, R.M., & Corey, L. (1990). Chronic fatigue A prospective clinical and virologic study. Journal of the American Medical Association, 264, 48–53.

    Article  PubMed  CAS  Google Scholar 

  • Goodnick, P.J. & Sandoval, R. (1993). Treatment of chronic fatigue syndrome and related disorders: immunological approaches. In P.J. Goodnick & N.G. Klimas (Eds.). Chronic Fatigue and Related Immune Deficiency Syndromes (pp. 109–129). Washington: American Psychiatric Press, Inc.

    Google Scholar 

  • Gow, J.W., Simpson, K., Schliephake, A., Behan, W.M.H., Morrison, L.J.A., Cavanagh, H., Rethwilm, A., & Behan, P.O. (1992). Search for retrovirus in the chronic fatigue syndrome. Journal of Clinical Pathology, 45, 1058–1061.

    Article  PubMed  CAS  Google Scholar 

  • Gupta, S. & Vayuvegula, B. (1991). A comprehensive immunological analysis in chronic fatigue syndrome. Scandinavian Journal of Immunology, 33, 319–327.

    Article  PubMed  CAS  Google Scholar 

  • Harbuz, M.S., Rees, R.G., Eckland, D., Jessop, D.S., Brewerton, D., & Lightman, S.L. (1992). Paradoxical responses of hypothalamic CRF mRNA and CRF-41 peptide and adenohypophyseal POMC mRNA during chronic inflammatory stress. Endocrinology, 130, 1394–1400.

    Article  PubMed  CAS  Google Scholar 

  • Harbuz, M.S. & Lightman, S.L. (1992). Stress and the hypothalamo-pi-tuitary adrenal axis: acute chronic and immunological activation. Journal of Endocrinology, 134, 327–329.

    Article  PubMed  CAS  Google Scholar 

  • Heneine, W., Woods, T.C., Dinha, S.D., Khan, A.S., Chapman, L.E., Schonberger, L.B., & Folks, T.M. (1994). Lack of evidence for infection with known human and animal retroviruses in patients with chronic fatigue syndrome. Clinical Infectious Diseases, 18(Suppl 1), S121–5.

    Article  PubMed  Google Scholar 

  • Hickie, I., Lloyd, A., Wakefield, D., & Parker, G. (1990). The psychiatric status of patients with the chronic fatigue syndrome. British Journal of Psychiatry, 156, 534–540.

    Article  PubMed  CAS  Google Scholar 

  • Hillhouse, E.W. & Milton, N.G.N. (1989). Effect of acetylcholine and 5-hydroxytryptamine on the secretion of corticotrophin-releasing factor-41 and arginine vasopressin from the rat hypothalamas in vitro. Journal of Endocrinology, 122, 713–718.

    Article  PubMed  CAS  Google Scholar 

  • Holmes, G.P., Kaplan, J.E., Gantz, N.M., Komaroff, A.L., Schonberger, L.B., Straus, S.E., Jones, J.F., Dubois, R.E., Cunningham-Rundles, C., Pahwa, S., Tosato, G., Zegans, L.S., Purtilo, D.T., Brown, N., Schooley, R.T., & Brus, I. (1988). Chronic fatigue syndrome: a working case definition. Annals of Internal Medicine, 108, 387–389.

    PubMed  CAS  Google Scholar 

  • Hu, S.-B., Lightman, S.L., & Tannahill, L.A. (1992). 5-hdroxytryptamine stimulates corticosteroid-sensitive CRF release from cultured foetal hypothalamic cells. Role of protein kinases. Brain Research, 574, 266–270.

    Article  PubMed  CAS  Google Scholar 

  • Imura, H., Fukata, J.-L, & Mori, T. (1991). Cytokines and endocrine function: an interaction between the immune and neuroendocrine systems. Clinical Endocrinology, 35, 107–115.

    Article  PubMed  CAS  Google Scholar 

  • Jefferies, W.McK. (1994). Mild adrenocortical deficiency, chronic allergies, autoimmune disorders and the chronic fatigue syndrome: a continuation of the cortisone story. Medical Hypotheses, 42, 183–189.

    Article  PubMed  CAS  Google Scholar 

  • Kastin, A.J., Seligson, J., Strimas, J.H., & Chi, D.S. (1991). Failure of metenkephalin to enhance natural killer cell activity. Immunobiology, 183, 55–68.

    Article  PubMed  CAS  Google Scholar 

  • Katon, W.J., Buchwald, D.S., Simon, G.E., Russo, J.E., & Mease, P.J. (1991). Psychiatric illness in patients with chronic fatigue and those with rheumatoid arthritus. Journal of General Internal Medicine, 6, 277–285.

    Article  PubMed  CAS  Google Scholar 

  • Katon, W.J. & Russo, J. (1992). Chronic fatigue syndrome criteria. A critique of the requirement for multiple physical complaints. Archives of Internal Medicine, 152, 1604–1609.

    Article  PubMed  CAS  Google Scholar 

  • Khan, A.S., Heneine, W., Chapman, L.E., Gary, Jr., H.E., Woods, T.C., Folks, T.M., & Schonberger, L.B. (1993). Assessment of a retrovirus sequence and other possible risk factors for the chronic fatigue syndrome in adults. Annals of Internal Medicine, 118, 241–245.

    PubMed  CAS  Google Scholar 

  • Klimas, N.G., Salvato, F.R., Morgan, R., & Fletcher, M.A. (1990). Immunologic abnormalities in chronic fatigue syndrome. Journal of Clinical Microbiology, 28, 1403–1410.

    PubMed  CAS  Google Scholar 

  • Kruesi, M.J.P., Dale, J., & Straus, S.E. (1989). Psychiatric diagnoses in patients who have chronic fatigue syndrome. Journal of Clinical Psychiatry, 50, 53–56.

    PubMed  CAS  Google Scholar 

  • Landay, A.L., Jessop, C., Lennette, E.T., & Levy, J.A. (1991). Chronic fatigue syndrome: clinical condition associated with immune activation. The Lancet, 338, 707–712.

    Article  CAS  Google Scholar 

  • Levy, A.D., Quan, L., Rittenhouse, P.A., & Van de Kar, K.D. (1993). Investigation of the role of 5-HT3 receptors in the secretion of prolactin, ACTH and renin. Neuroendocrinology, 58, 65–70.

    Article  PubMed  CAS  Google Scholar 

  • Levy, J.A. (1994). Part III: Viral studies of chronic fatigue syndrome. Clinical Infectious Diseases, 18 (Suppl 1), S117–S120.

    Article  PubMed  Google Scholar 

  • Levy, J.A., Landay, A.L., Jessop, C. & Lennette, E. (1993). Chronic fatigue syndrome: Is it a state of chronic immune activation against on infectious virus? In P.J. Goodnick & N.G. Klimas (Eds.). Chronic Fatigue and Related Immune Deficiency Syndromes, (pp. 127–145). Washington: American Psychiatric Press, Inc.

    Google Scholar 

  • Linde, A., Andersson, B., Svenson, S.B., Ahrne, H., Carlsson, M., Forsberg, R, Hugo, H., Karstorp, A., Lenkei, R., Lindwall, A., Loftenius, A., Sall, C., & Andersson, J. (1992). Serum levels of lymphokines and soluble cellular receptors in primary epstein-barr virus infection and in patients with chronic fatigue syndrome. Journal of Infectious Diseases, 165, 994–1000.

    Article  PubMed  CAS  Google Scholar 

  • Lloyd, A., Gandevia, S., Brockman, A., Hales, J., & Wakefield, D. (1994). Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise. Clinical Infectious Diseases, 18(Suppl 1), S142–6.

    Article  PubMed  Google Scholar 

  • Lloyd, A., Hickie, I., Brockman, A., Dwyer, J., & Wakefield, D. (1991). Cytokine levels in serum and cerebrospinal fluid in patients with chronic fatigue syndrome and control subjects. Journal of Infectious Diseases, 164, 1023–1024.

    Article  PubMed  CAS  Google Scholar 

  • MacLeam, G. & Wessely, S. (1994). Professional and popular views of chronic fatigue syndrome. British Medical Journal, 308(6931), 776–777.

    Article  Google Scholar 

  • Maness, L.M., Banks, W.A., Zadina, J.E., & Kastin, A.J. (1995). Selective transport of blood-borne interleukin-lα into the posterior division of the septum of the mouse brain. Brain Research, 700, 83–88.

    Article  PubMed  CAS  Google Scholar 

  • Martins, J.M., Kastin, A.J., & Banks, W.A. (1996). Unidirectional specific and modulated brain to blood transport of corticotropin-releasing hormone. Neuroendocrinology, (in press).

    Google Scholar 

  • Mawle, A.C., Reyes, M., & Schmid, D.S. (1994). Is chronic fatigue syndrome an infectious disease? Infectious Agents and Disease, 2, 333–341.

    Google Scholar 

  • Meaney, M.J., Mitchell, J.B., Aitken, D.H., Bhatnagar, S., Bodnoff, S.R., Iny, L.J., & Sarrieau, A. (1991). The effects of neonatal handling on the development of the adrenocortical response to stress: implications for neuropathology and cognitive deficits in later life. Psychoneuroendocrinology, 16, 85–103.

    Article  PubMed  CAS  Google Scholar 

  • Mendelson, S.D. & McEwen, B.S. (1992). Autoradiographic analyses of the effects of adrenalectomy and corticosterone on 5-HT1A and 5-HT1B receptors in the dorsal hippocampus and cortex of the rat. Neuroendocrinology, 55, 444–450.

    Article  PubMed  CAS  Google Scholar 

  • Miller, N.A., Carmichael, H.A., Calder, B.D., Behan, P.O., Bell, E.J., McCartney, R.A., & Hall, F.C. (1991). Antibody to Coxsackie B virus in diagnosing postviral fatigue syndrome. British Medical Journal, 302, 140–143.

    Article  PubMed  CAS  Google Scholar 

  • Moldofsky, H. (1995). Sleep, neuroimmune and neuroendocrine functions in fibromyalgia and chronic fatigue syndrome. Advances in Newoimmunology, 5, 39–56.

    Article  CAS  Google Scholar 

  • Moldow, R.L., Kastin, A.J., Graf, M., & Fischman, A.J. (1987). Stress mediated changes in hypothalamic corticotropin releasing factor — like immunoreactivity. Life Sciences, 40, 413–418.

    Article  PubMed  CAS  Google Scholar 

  • Morris, R., Sharpe, M., Sharpley, A.L., Cowen, P.J., Hawton, K., & Morris, J. (1993). Abnormalities of sleep in patients with the chronic fatigue syndrome. British Medical Journal, 306, 1161–1164.

    Article  PubMed  Google Scholar 

  • Newsholme, E.A., Blomstrand, E., Hassmen, P., & Ekblom, B. (1991). Physical and mental fatigue: do changes in plasma amino acids play a role? Biochemical Society Transactions, 19, 358–362.

    PubMed  CAS  Google Scholar 

  • Patarca, R., Fletcher, M.A. & Klimas, N.G. (1993). Immunological correlates of chronic fatigue syndrome. In P.J. Goodnick & N.G. Klimas (Eds.). Chronic Fatigue and Related Immune Deficiency Syndromes (pp. 1–21). Washington: American Psychiatric Press, Inc.

    Google Scholar 

  • Patarca, R., Klimas, N.C., Lugtendorf, S., Antoni, M., & Fletcher, M.A. (1994). Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of oluble immune mediator expression. Clinical Infectious Diseases, 18 (Suppl 1), S147–S153.

    Article  PubMed  Google Scholar 

  • Poteliakhoff, A. (1981). Adrenocortical activity and some clinical findings in acute and chronic fatigue. Journal of Psychosomatic Research, 25, 91–95.

    Article  PubMed  CAS  Google Scholar 

  • Rasmussen, A.K., Nielsen, H., Andersen, V., Barington, T., Bendtzen, K., Hansen, M.B., Nielsen, L., Pedersen, B.K., & Wiik, A. (1994). Chronic fatigue syndrome—a controlled cross sectional study. Journal of Rheumatology, 21, 1527–1531.

    PubMed  CAS  Google Scholar 

  • Reul, J.M.H.M., Stec, I., Wiegars, J.W., Labeur, M.S., Linthorst, A.C.E., & Arzt, E. (1994). Prenatal immune challenge alters the hypotha-lamic-pituitary-adrenocortical axis in adult rats. Journal of Clinical Investigation, 93, 2600–2607.

    Article  PubMed  CAS  Google Scholar 

  • Sandman, C.A., Barron, J.L., Nackoul, K., Goldstein, J., & Fidler, F. (1993). Memory deficits associated with chronic fatigue immune dysfunction syndrome. Biological Psychiatry, 33, 618–623.

    Article  PubMed  CAS  Google Scholar 

  • Spinedi, E., Salas, M., Chisari, A., Perone, M., Carino, M., & Gaillard, R.C. (1994). Sex differences in the hypothalamo-pituitary-adrenal axis response to inflammatory and neuroendocrine stressors. Neuroendocrinology, 60, 609–617.

    Article  PubMed  CAS  Google Scholar 

  • Sternberg, E.M., Hill, J.M., Chrousos, G.P., Kamilaris, T., Listwak, S.J., Gold, P.W., & Wilder, R.L. (1989). Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritus-susceptible Lewis rats. Proceedings of the National Academy of Sciences of the United States of America, 86, 2374–2378.

    CAS  Google Scholar 

  • Straus, S.E., Dale, J.K., Peter, J.B., & Dinarello, C.A. (1989). Circulating lymphoklne levels in the chronic fatigue syndrome. Journal of Infectious Diseases, 160, 1085–1086.

    Article  PubMed  CAS  Google Scholar 

  • Straus, S.E., Fritz, S., Dale, J.K., Gould, B., & Strober, W. (1993). Lymphocyte phenotype and function in the chronic fatigue syndrome. Journal of Clinical Immunology, 13, 30–40.

    Article  PubMed  CAS  Google Scholar 

  • Suda, T., Tozawa, F., Ushiyama, T., Sumitoma, T., Yamada, M., & Demura, H. (1990). Interleukin-1 stimulates corticotropin-releasing factor gene expression in rat hypothalamus. Endocrinology, 126, 1223–1227.

    Article  PubMed  CAS  Google Scholar 

  • Swain, M.G., Patchev, V., Vergalla, J., Chrousos, G., & Jones, E.A. (1993). Suppression of hypothalamic-pituitary-adrenal axis responsiveness to stress in a rat model of acute cholestasis. Journal of Clinical Investigation, 91, 1903–1908.

    Article  PubMed  CAS  Google Scholar 

  • Waguespack, P.J., Banks, W.A., & Kastin, A.J. (1994). Interleukin-2 does not cross the blood-brain barrier by a saturable transport system. Brain Research Bulletin, 34, 103–109.

    Article  PubMed  CAS  Google Scholar 

  • Wessely, S., Chalder, T., Hirsch, S., Pawlikowska, T., Wallace, P., & Wright, D.J.M. (1995). Postinfectious fatigue: prospective cohort study in primary care. The Lancet, 345, 1333–1338.

    Article  CAS  Google Scholar 

  • Wick, G., Hu, S., Schwarz, S., & Kroemer, G. (1993). Immunoendocrine communications via the hypothalamo-pituitary-adrenal axis in autoimmune diseases. Endocrine Review, 14, 539–563.

    CAS  Google Scholar 

  • Wilson, A., Hickie, I., Lloyd, A., & Wakefield, D. (1994). The treatment of chronic fatigue syndrome: science and speculation. American Journal of Medicine, 95(6), 544–550.

    Article  Google Scholar 

  • Zhukov, D.A. (1993). The dexamethasone suppression test in genetically different rats exposed to inescapable and escapable electric shocks. Psychoneuroendocrinology, 18, 467–474.

    Article  PubMed  CAS  Google Scholar 

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Kastin, A.J., Olson, R.D., Martins, J.M., Olson, G.A., Zadina, J.E., Banks, W.A. (1997). Chronic Fatigue Syndrome: Possible Integration of Hormonal and Immunological Observations. In: Yehuda, S., Mostofsky, D.I. (eds) Chronic Fatigue Syndrome. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5953-5_8

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