Abstract
In this symposium, we will review our rationale and experience with pharmacologic strategies for the promotion of myelin repair in inflammatory demyelinating disease. The most common clinical form of these illnesses in humans is multiple sclerosis (MS). MS and most other forms of inflammatory demyelination consist of an idiopathic. inflammatory syndrome which affects predominantly the densely myelinated white matter of the central nervous system (CNS). The inflammatory response is associated with damage of oligodendrocytes (ODC) and myelin, resulting in loss of these tissue elements (reviewed in Hunter & Rodriguez, 1995). Similar diseases exist in animals of both idiopathic and viral origin. Theiler’s murine encephalomyelitis virus (TMEV), a naturally occurring, murine, picornaviral pathogen, produces inflammatory demyelinating lesions in spinal cord and brainstem with progressive neurologic disability in susceptible mouse strains.
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Hunter, S.F., Asakura, K., Miller, D.J., Rodriguez, M. (1997). The Repair of Central Nervous System Myelin. In: Juurlink, B.H.J., Devon, R.M., Doucette, J.R., Nazarali, A.J., Schreyer, D.J., Verge, V.M.K. (eds) Cell Biology and Pathology of Myelin. Altschul Symposia Series, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5949-8_25
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DOI: https://doi.org/10.1007/978-1-4615-5949-8_25
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