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Cell Biology and Pathology of Myelin pp 213–221Cite as

Expansion of Oligodendrocyte Progenitors for Myelin Repair

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Part of the book series: Altschul Symposia Series ((ALSS,volume 4))

Abstract

The myelin sheath is a multilamellar extension of the cell membrane of the oligodendrocyte in the central nervous system (CNS) and of the Schwann cell in the peripheral nervous system (PNS). Processed mainly during postnatal development, it is considered a stable structure in the adult nervous system. Since its function is to promote and secure electrical conduction, alteration or destruction of the myelin sheath during adult life can cause severe impairement of neurologic function. Recurrent events of demyelination in the CNS occur in multiple sclerosis, leading to the destruction and depletion of the oligodendroglial population. Therefore, the development of strategies to promote myelin repair by replacement of the affected oligodendroglial population could become instrumental in the treatment of demyelinating diseases.

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References

  • Avellana-Adalid V, Nait-Oumesmar B, Bachelin C, Simao ML, Baron-Van Evercooren A (1996a): Expansion of rat oligodendrocyte progenitors into proliferative `oligospheres“ that retain differentiation potential. J Neurosci Res 45: 558–570.

    Article  CAS  Google Scholar 

  • Avellana-Adalid, V, Nait-Oumesmar B, Bachelin C, Simao ML, Baron-Van Evercooren A (1996b): Oligodendro-cyte progenitors. Isolation and expansion as oligospheres. In Griffiths JB, Doyle A. Newell DO (eds): “Cell & Tissue Culture: Laboratory Procedures.” England, John Wiley & Sons Limited. (submitted)

    Google Scholar 

  • Baron-Van Evercooren A (1994): Future prospects in transplantation. Ann Neurol 36:151–156.

    Article  Google Scholar 

  • Barnett SC, Franklin RJM, Blakemore WF (1993): In vitro and in vivo analysis of a rat bipotential O-2A progenitor cell line containing the temperature sensitive mutant gene of the SV40 large T antigen. Eur J Neurosci 5:1247–1260.

    Article  PubMed  CAS  Google Scholar 

  • Barres BA, Raff. MC (1994): Control of oligodendrocyte number in the developing rat optic nerve. Neuron 12: 935–942.

    Article  PubMed  CAS  Google Scholar 

  • Barres BA, Schmid R, Sendter M, Raff MC (1993): Multiple extracellular signals are required for long-term oligodendrocyte survival. Development 118: 283–295.

    PubMed  CAS  Google Scholar 

  • Blakemore WF, Crang A. Franklin R. (1995): Transplantation of glial cells. In Ransom BR. Kettenman H. (eds): “Neuroglial cells.” Cambridge, England, Oxford University Press.

    Google Scholar 

  • Bogler O. Wren D, Barnett SC, Land H, Noble M (1990): Cooperation between two growth factors promotes extended self-renewal and inhibts differentiation of O-2A progenitor cells. Proc Natl Acad Sci USA 87: 6368–6372.

    Article  PubMed  CAS  Google Scholar 

  • Canoll P, Musacchio J, Hardy R, Reynolds R, Marchionni M, Salzer J (1996): GGF/Neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors. Neuron 17: 229–243.

    Article  PubMed  CAS  Google Scholar 

  • Dubois-Dalcq M. Behar T. Hudson LD, Lazzarini R (1986): Energence of three myelin proteins in oligodendrocyte cultured without neurons. J Cell Biol 102: 384–392.

    Article  PubMed  CAS  Google Scholar 

  • Duncan I. Milward E (1995): Glial cell transplants: experimental therapies of myelin diseases. Brain Pathol 5: 301–310.

    Article  PubMed  CAS  Google Scholar 

  • Eisenberth G, Walsh F, Nirenberg M (1979): Monoclonal antibody to a plasma membrane antigen of neurons. Proc Natl Acad Sci USA 76: 4913–4917.

    Article  Google Scholar 

  • Farranaga M, Sommer I, Griffiths I (1995): 02A progenitors of the mouse optic nerve exhibit a developmental pattern of antigen expression different from the rat. Glia 15:95–104.

    Article  Google Scholar 

  • Franklin R, ffrench-Constant C (1996): Transplantation and repair in Multiple Sclerosis. In Russel WC (ed): “The Molecular Biology of Multiple Sclerosis.” John Wiley and Sons, pp 231–242.

    Google Scholar 

  • Franklin R, Bayley, S, Milner R, ffrench-Constant C, Blakemore WF (1995): Differentiation of the O-2A progenitor cell line CG-4 into oligodendrocytes and astrocytes following transplantation into glia-deficient areas of CNS white matter. Glia 13: 39–44.

    Article  PubMed  CAS  Google Scholar 

  • Gallo V, Armstrong RC (1995): Developmental and growth factor-induced regulation of nestin in oligodendrocyte lineage cells. J Neurosci 15 (1): 394–406.

    PubMed  CAS  Google Scholar 

  • Goldman JE (1992): Regulation of oligodendrocyte differentiation. TINS 10: 359–362.

    Google Scholar 

  • Grinspan J, Franceschini B (1995): Platelet-derived growth factor is a survival factor for PSA-NCAM+ oligodendrocyte pre-progenitor cells J Neurosci Res 41: 540–551.

    CAS  Google Scholar 

  • Groves A, Barnett S, Franklin R, Crang AA, Mayer M, Blakemore WF, Noble M (1993): Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells. Nature 362: 453–455.

    Article  PubMed  CAS  Google Scholar 

  • Guillian D, Johnson B, Krebs JF, Tapscott MJ, Honda S, (1991): A growth factor from neuronal cell lines simulates myelin protein synthesis in mammalian brain. J Neurosci 11: 327–336.

    Google Scholar 

  • Gumpel M, Baumann N, Raoul M, Jacque C (1983): Survival and differenciation of oligodendrocytes from neural tissue transplanted into new-born mouse brain. Neurosci Lett 37: 307–312.

    Article  PubMed  CAS  Google Scholar 

  • Gumpel M (1991): Shiverer and other marker models used in intracerebral transplantations of glial cells. Trans-plants, implants and grafts. In: Methods in Neurosci., Vol 7, Academic Press, New-York, 378–394.

    Google Scholar 

  • Hardy R, Reynolds R (1991): Proliferation and differentiation potential of rat forbrain oligodendroglia progenitors both in vitroand in vivo. Development 111: 1061–1070.

    PubMed  CAS  Google Scholar 

  • Hardy R, Reynolds R (1993a): Neuron-oligodendroglial interactions during central nervous system development. J Neurosci Res 36: 121–126.

    Article  CAS  Google Scholar 

  • Hardy R, Reynolds R (1993b): Rat cerebral cortical neurons in primary culture release a mitogen specific for early (GD3+:04-) oligodendroglial progenitors. J Neurosci Res 34: 589–600.

    Article  CAS  Google Scholar 

  • Hunter S.F, Bottenstein JE (1990): Growth factor responses of enriched bipotential glial progenitors. Dev Brain Res 54: 235–248.

    Article  CAS  Google Scholar 

  • Hunter SF, Bottenstein JE (1991): O-2A glial progenitors from mature brain respond to CNS neuronal cell-derived growth factors. J Neurosci Res 28: 574–582.

    Article  PubMed  CAS  Google Scholar 

  • Kreider B, Grinspan J, Waterstone M, Bramblett G, Ances B, Williams M, Stern J, Lee V, Pleasure D (1996): Partial purification of a novel mitogen for oligodendroglia. J Neurosci Res 40: 44–53.

    Article  Google Scholar 

  • Lachapelle F, Gumpel M, Baulac M, Jacque C, Duc P, Baumann N (1983): Transplantation of CNS fragments into the brain of shiverer mutant mice: extensive myelination by transplanted oligodendrocytes I: Immunohistochemical studies. Dev Neurosci 6: 325–334.

    Article  PubMed  Google Scholar 

  • Lachapelle F, Nait-Oumesmar B, Avellana-Adalid V, Bargey N, Seilhan D, Baron-Van Evercooren A (1996): FGF2, EGF and PDGF A differentially activate in vivothe potential of grafted cells derived from the adult sub-ventricular zone to generate myelin-forming oligodendrocytes. J Neurosci 390: 14.

    Google Scholar 

  • Louis JC, Magal E, Muir D, Manthorpe M, Varon S (1992): CG-4, A new bipotential glial cell line from rat brain, is capable of differentiating in vitrointo either mature oligodendrocytes or type-2 astrocytes. J Neurosci Res 31: 193–204.

    Article  PubMed  CAS  Google Scholar 

  • McKinnon RD, Matsui T, Dubois-Dalcq M, Aaronson SA (1990): FGF modulates the PDGF-driven pathway of oligodendrocyte development. Neuron 5: 603–614.

    Article  PubMed  CAS  Google Scholar 

  • McKinnon RD, Dubois-Dalcq M (1995): Cytokines and growth factors in the development and regeneration of oligodendrocytes. In Benveniste E, Ransohoff R (eds.): “Cytokines and the CNS; Development, Defense and Disease.” Boca-Raton, Florida: CRC.

    Google Scholar 

  • McMorris FA, Dubois-Dalcq M, (1988): Insulin-like growth factor I promotes cell proliferation and oligodendro-glial commitment in rat glial progenitor cells developing in vitro. J Neurosci Res 21:199–209.

    Article  CAS  Google Scholar 

  • Nait-Oumesmar B, Lachapelle F, Vignais L, Bachelin C, Rougon G, Baron-Van Evercooren A (1996): Potential of repair of the adult subventricular zone following chemically induced demyelination J Neurosci 390: 13.

    Google Scholar 

  • Noble M, Murray K, Stroobant P, Waterfield MD, Riddle P (1988): Platelet-derived growth factor promtes divi-sion and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell. Nature 333: 560–562.

    Article  PubMed  CAS  Google Scholar 

  • Pfeiffer S, Warrington A, Bansal R (1993): The oligodendrocyte and its many cellular processes. Trends Cell Biol 3: 191–197.

    Article  PubMed  CAS  Google Scholar 

  • Raff MC (1989): Glial cell diversification in the rat optic nerve. Science 243: 1450–1455.

    Article  PubMed  CAS  Google Scholar 

  • Raff MC, Lillien LE, Richardson WD, Burne JF Noble MD (1988): Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocytc development in culture. Nature 333: 562–565.

    Article  PubMed  CAS  Google Scholar 

  • Raff MC, Miller RH Noble M (1983): A glial progenitor cell that develops in vitrointo an astrocyte or an oligodendrocyte depending on the culture medium. Nature 303: 390–396.

    Article  PubMed  CAS  Google Scholar 

  • Richardson W, Pringle N, Mosley M, Westermark B, Dubois-Dalcq M (1988): A role for platelet-derived growth factor in normalgliogenesis in the central nervous system Cell 53: 309.

    CAS  Google Scholar 

  • Small RK, Riddle P, Noble M (1987): Evidence for migration of oligodendrocyte-type2 astrocyte precursor cells into the developing rat optic nerve. Nature 328: 155–157.

    Article  PubMed  CAS  Google Scholar 

  • Sommer I, Schachner M (1981): Monoclonal antibodies (01–04) to oligodendrocyte cell surfaces: an immunological study in the central nervous system. Dev Biol 83:311–327.

    Article  PubMed  CAS  Google Scholar 

  • Tontsch U, Archer D, Dubois-Dalcq M, Duncan I (1994): Transplantation of an oligodendrocyte cell line leading to extensive myelination. Proc Natl Acad Sci USA 91: 11616–11620.

    Article  PubMed  CAS  Google Scholar 

  • Trotter J, Bitter-Suermann D, Schachner M (1989): Differentiation-regulated loss of the polysialy)ated embryonic form and expression of the different polypeptides of the neural cell adhesion molecule by cultured oligodendrocytes and myelin. J Neurosci Res 22:369–383.

    Article  PubMed  CAS  Google Scholar 

  • Trotter J, Crang AJ, Schachner M, Blakemore WF (1993) Lines of glial precursor cells immortalised with a temperature-sensitive oncogene give rise to astrocytes and oligodendrocytes following transplantation into demyelinated lesions in the central nervous system. Glia, 9: 25–40.

    Article  PubMed  CAS  Google Scholar 

  • Vignais L, Nait-Oumesmar B, Mellouk F, Gout O, Labourdette G, Baron-Van Evercooren A, Gumpel M (1993): Migration and differentiation of transplanted oligodendrocyte precursors in the adult demyelinated spinal cord. lnt J Dev Neurosci 11 603–611.

    Article  CAS  Google Scholar 

  • Warrington AE, Barbarese E, Pfeiffer SE (1993): Differential myelinogenic capacity of specific developmental stages of the oligodendrocyte lineage upon transplantation into hypomyelinating hosts. J Neurosci Res 34: 1–13.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. U134 INSERM Laboratoire de Neurobiologie Cellulaire, Moleculaire et Clinique, Hopital de la Salpêtrière, 75651, Paris cedex 13, France

    A. Baron-Van Evercooren, V. Avellana-Adalid, S. Vitry, B. Nait-Oumesmar & F. Lachapelle

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  1. A. Baron-Van Evercooren
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  2. V. Avellana-Adalid
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  3. S. Vitry
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  4. B. Nait-Oumesmar
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  5. F. Lachapelle
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Editors and Affiliations

  1. University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Bernhard H. J. Juurlink , Richard M. Devon , J. Ronald Doucette , Adil J. Nazarali , David J. Schreyer  & Valerie M. K. Verge , , , ,  & 

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Baron-Van Evercooren, A., Avellana-Adalid, V., Vitry, S., Nait-Oumesmar, B., Lachapelle, F. (1997). Expansion of Oligodendrocyte Progenitors for Myelin Repair. In: Juurlink, B.H.J., Devon, R.M., Doucette, J.R., Nazarali, A.J., Schreyer, D.J., Verge, V.M.K. (eds) Cell Biology and Pathology of Myelin. Altschul Symposia Series, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5949-8_21

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  • DOI: https://doi.org/10.1007/978-1-4615-5949-8_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-45595-7

  • Online ISBN: 978-1-4615-5949-8

  • eBook Packages: Springer Book Archive

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