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Role of cAMP during the Process of Demyelination and Remyelination in Peripheral Nerve

  • Chapter
Cell Biology and Pathology of Myelin

Part of the book series: Altschul Symposia Series ((ALSS,volume 4))

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Abstract

Myelin is a multilamellar structure that surrounds axons to increase axonal conduction velocity and provide trophic support. In the peripheral nervous system, it is formed by the spiral wrapping of the cell membrane of myelinating Schwann cells (SCs) around axons. The SC phenotype is dependent on its association with an axon. Axonal contact Induces the expression of myelin-specific proteins, including P0, myelin basic protein, peripheral myelin protein-22, and myelin associated glycoprotein (Wood and Engel, 1976; Uyemura et al., 1979; Carson et al., 1983; Poduslo, 1984; Gupta et al., 1988; Lemke and Chao, 1988; LeBlanc and Poduslo, 1990). With the onset of myelination, the amount of these myelin proteins and the steady state levels of their mRNAs increases dramatically.

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Author information

Authors and Affiliations

  1. Molecular Neurobiology Laboratory Departments of Neurology and Biochemistry/Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, 55905, USA

    Randall S. Walikonis & Joseph F. Poduslo

Authors
  1. Randall S. Walikonis
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  2. Joseph F. Poduslo
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Editor information

Editors and Affiliations

  1. University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Bernhard H. J. Juurlink , Richard M. Devon , J. Ronald Doucette , Adil J. Nazarali , David J. Schreyer  & Valerie M. K. Verge , , , ,  & 

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© 1997 Springer Science+Business Media New York

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Walikonis, R.S., Poduslo, J.F. (1997). Role of cAMP during the Process of Demyelination and Remyelination in Peripheral Nerve. In: Juurlink, B.H.J., Devon, R.M., Doucette, J.R., Nazarali, A.J., Schreyer, D.J., Verge, V.M.K. (eds) Cell Biology and Pathology of Myelin. Altschul Symposia Series, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5949-8_13

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  • DOI: https://doi.org/10.1007/978-1-4615-5949-8_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-45595-7

  • Online ISBN: 978-1-4615-5949-8

  • eBook Packages: Springer Book Archive

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