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Cell Biology and Pathology of Myelin pp 115–122Cite as

Posttranscriptional Regulation of Myelin Basic Protein Gene Expression

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Part of the book series: Altschul Symposia Series ((ALSS,volume 4))

Abstract

The myelin basic protein (mbp) gene has been the subject of intense study since its structure was first elucidated over a decade ago. Recently, the mbp transcription unit has been found to be embedded within a larger unit called the golli gene (Campagnoni et al., 1993; Pribyl et al., 1993). This unusual genetic locus, which we call the golli-mbp gene, gives rise to two families of alternatively spliced transcripts under the control of different promoters. The mRNAs of both the golli gene and mbp gene are under independent developmental, cellular and tissue regulation. Interestingly, expression of the mbp gene appears to be confined exclusively to the later stages of differentiation of myelin forming cells whereas expression of the golli gene is less restricted.

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Authors and Affiliations

  1. Mental Retardation Research Center and Brain Research Institute, UCLA Medical School, 760 Westwood Plaza, Los Angeles, California, 90095, USA

    Anthony T. Campagnoni

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  1. Anthony T. Campagnoni
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Editors and Affiliations

  1. University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Bernhard H. J. Juurlink , Richard M. Devon , J. Ronald Doucette , Adil J. Nazarali , David J. Schreyer  & Valerie M. K. Verge , , , ,  & 

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© 1997 Springer Science+Business Media New York

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Campagnoni, A.T. (1997). Posttranscriptional Regulation of Myelin Basic Protein Gene Expression. In: Juurlink, B.H.J., Devon, R.M., Doucette, J.R., Nazarali, A.J., Schreyer, D.J., Verge, V.M.K. (eds) Cell Biology and Pathology of Myelin. Altschul Symposia Series, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5949-8_11

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  • DOI: https://doi.org/10.1007/978-1-4615-5949-8_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-45595-7

  • Online ISBN: 978-1-4615-5949-8

  • eBook Packages: Springer Book Archive

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