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Advances in Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy pp 235–255Cite as

An Ammonia Hypothesis of Alzheimer Disease

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 420))

Abstract

There is little doubt that dementia of the Alzheimer type (DAT) is a multifactorial disease. The existence of a major gene for DAT is equivocal, however, a genetic predisposition is considered to be likely from the high concordance of DAT in monozygotic and dizygotic twins (1), and an increased frequency of the disease in relatives of affected patients (2). The long arm of chromosome 21 is the locus of predisposition (3). The expression of a number of genes encoding for various neuronal and non-neuronal proteins is also changed in DAT brains (4).

“All this has been said before, but since nobody listened, it must be said again.”

André Gide

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  1. Groupe de Recherche en Thérapeutique Anticancéreuse, URA, CNRS 1529, Institut de Recherche Contre le Cancer, Faculté de Médecine, Université de Rennes 1, 2 av. du Pr. Léon Bernard, F-35043, Rennes, Cedex, France

    Nikolaus Seiler

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  1. Instituto de Investigaciones Citologicas de la F. V. I. B., Valencia, Spain

    Vicente Felipo  & Santiago Grisolía  & 

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© 1997 Plenum Press, New York

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Seiler, N. (1997). An Ammonia Hypothesis of Alzheimer Disease. In: Felipo, V., Grisolía, S. (eds) Advances in Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy. Advances in Experimental Medicine and Biology, vol 420. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5945-0_16

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  • DOI: https://doi.org/10.1007/978-1-4615-5945-0_16

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