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Autoimmune Retinopathy

Cystoid Macular Edema in Retinitis Pigmentosa Patients

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Degenerative Retinal Diseases

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Abstract

Patients with panretinal degeneration who also had bilateral foveal cysts or cystoid edema were compared to normal controls and to patients with retinitis pigmentosa (RP) who did not have foveal cysts. Their serum was examined for the presence of antibodies that immunoreacted with retinal proteins. Twenty-seven of 30 patients with bilateral cystoid edema and retinal degeneration had serum anti-retinal protein antibody activity, compared to 3/50 healthy donors and only 4 of 30 patients with RP lacking foveal cysts. The high correlation observed suggests that there is an autoimmune component of the cystoid edema present in RP patients that is absent in controls and in patients with RP without cystoid edema. The significance of the antibodies to retinal proteins in the pathophysiology of the disease process is currently under study.

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Author information

Authors and Affiliations

  1. UCLA Medical Center, The Jules Stein Eye Institute, Los Angeles, California, 90024, USA

    John R. Heckenlively

  2. Department of Ophthalmology, University of Florida, Gainesville, Florida, 32610, USA

    Nata Aptsiauri & Paul A. Hargrave

Authors
  1. John R. Heckenlively
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  2. Nata Aptsiauri
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  3. Paul A. Hargrave
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Editor information

Editors and Affiliations

  1. University of California, San Francisco, San Francisco, California, USA

    Matthew M. LaVail

  2. Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Joe G. Hollyfield

  3. University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

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© 1997 Springer Science+Business Media New York

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Heckenlively, J.R., Aptsiauri, N., Hargrave, P.A. (1997). Autoimmune Retinopathy. In: LaVail, M.M., Hollyfield, J.G., Anderson, R.E. (eds) Degenerative Retinal Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5933-7_7

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  • DOI: https://doi.org/10.1007/978-1-4615-5933-7_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7718-4

  • Online ISBN: 978-1-4615-5933-7

  • eBook Packages: Springer Book Archive

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