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Degenerative Retinal Diseases pp 385–397Cite as

Further Studies on the Phagocytosis of Photoreceptor Outer Segments by Rat Retinal Pigment Epithelial Cells

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Abstract

The shedding of photoreceptor outer segments (OS) and their phagocytosis by the adjacent retinal pigment epithelium (RPE) is a fundamental process which occurs in all vertebrate species studied to date. Numerous studies have showed that OS shedding and phagocytosis is light entrained and follows a circadian rhythm (1, 2). When this process goes awry, such as in the RCS rat (3–5) and possibly in the vitiligo mouse (6, 7) degeneration of the OS soon follows. There is an accumulating body of evidence (8) that the phagocytosis of OS is a receptor mediated process, whereby a specific receptor on the RPE (the phagocytosis receptor) recognizes a ligand on the surface of the shed OS. After binding to the receptor, the shed OS is internalized by the RPE cell, where it undergoes digestion by lysosomal enzymes.

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Author information

Authors and Affiliations

  1. UCLA Medical Center, Jules Stein Eye Institute, 100 Stein Plaza, Los Angeles, California, 90095-7008, USA

    Michael O. Hall, Toshka A. Abrams, Barry L. Burgess & Alexey V. Ershov

Authors
  1. Michael O. Hall
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  2. Toshka A. Abrams
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  3. Barry L. Burgess
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  4. Alexey V. Ershov
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Editor information

Editors and Affiliations

  1. University of California, San Francisco, San Francisco, California, USA

    Matthew M. LaVail

  2. Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Joe G. Hollyfield

  3. University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

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© 1997 Springer Science+Business Media New York

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Hall, M.O., Abrams, T.A., Burgess, B.L., Ershov, A.V. (1997). Further Studies on the Phagocytosis of Photoreceptor Outer Segments by Rat Retinal Pigment Epithelial Cells. In: LaVail, M.M., Hollyfield, J.G., Anderson, R.E. (eds) Degenerative Retinal Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5933-7_42

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  • DOI: https://doi.org/10.1007/978-1-4615-5933-7_42

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7718-4

  • Online ISBN: 978-1-4615-5933-7

  • eBook Packages: Springer Book Archive

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