Abstract
Constant light damage in albino rats has become a useful model for testing the therapeutic potential of survival factors to protect photoreceptors from cell damage and death. Considerable variation occurs among animals in light damage experiments. An additional complication with the light damage model is that less damaged photoreceptors show greater protection by a given survival factor than those that are more severely damaged by light. A method is described that allows for comparison of relatively small numbers of animals and considers variability, relative degree of protection by survival factors and other qualitative measures of damage.
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LaVail, M.M., Matthes, M.T., Yasumura, D., Faktorovich, E.G., Steinberg, R.H. (1997). Histological Method to Assess Photoreceptor Light Damage and Protection by Survival Factors. In: LaVail, M.M., Hollyfield, J.G., Anderson, R.E. (eds) Degenerative Retinal Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5933-7_41
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DOI: https://doi.org/10.1007/978-1-4615-5933-7_41
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