Abstract
Age-related macular degeneration (AMD), the leading cause of irreversible blindness in the industrialized world, is characterized, in part, by the presence of drusen and basal laminar deposits (BLD) in the macula. Drusen are extracellular deposits which form between the retinal pigment epithelial (RPE) basal lamina and the inner collagenous zone of Bruch’s membrane. Although the relationship between macular drusen and the development of AMD has been established in a number of studies (1–4), relatively little is known about their composition or origin. Thorough characterization of these age-related deposits has been hampered by a paucity of suitable human donor tissues and the lack of an appropriate animal model of the disease.
Supported in part by NIH grants EY06463 and EY11515 (GSH) and an unrestricted grant to the Anheuser-Busch Eye Institute from Research to Prevent Blindness, Inc.
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Mullins, R.F., Hageman, G.S. (1997). Histochemical Comparison of Ocular “Drusen” in Monkey and Human. In: LaVail, M.M., Hollyfield, J.G., Anderson, R.E. (eds) Degenerative Retinal Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5933-7_1
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