Abstract
The W/Wv mouse is an important model with which to investigate azoospermia and its consequences in a mammalian system. The W locus encodes the transmembrane tyrosine kinase receptor c-kit (Chabot et al., 1988). Mutations in the c-kit gene affect the differentiation of hematopoetic stem cells, melanocyte progenitors and primordial germ cells. The latter results in infertility due to azoospermia.
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© 1997 Springer Science+Business Media New York
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Hansis, C., Jähner, D., Spiess, AN., Ivell, R. (1997). Differential Display PCR Cloning of W/Wv-Mutant Testis Specific Genes. In: Ivell, R., Holstein, AF. (eds) The Fate of the Male Germ Cell. Advances in Experimental Medicine and Biology, vol 424. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5913-9_25
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DOI: https://doi.org/10.1007/978-1-4615-5913-9_25
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