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Regulation of Mitochondrial Cholesterol Metabolism

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Book cover Cholesterol

Part of the book series: Subcellular Biochemistry ((SCBI,volume 28))

Abstract

Cholesterol is required for the growth and replication of mammalian cells. As an integral component of membranes, particularly the plasmalemma, cholesterol facilitates membrane curvature and increases resistance to physical damage. The insertion of cholesterol into membranes increases fluidity (Chapman, 1975), a property closely correlated with the cholesterol/phospholipid (C/PL) ratio. Cholesterol is also the substrate for the production of bile acids and steroid hormones. Because of cholesterol’s importance to cellular function, intracellular cholesterol concentrations are highly regulated (Yeagle, 1985; Lange and Ramos, 1983). Indeed, increases or decreases in this sterol can produce major alterations in cell physiology.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Medicine, UNAM, Mexico

    Federico Martínez

  2. Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA

    Jerome F. Strauss III

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  1. Federico Martínez
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  2. Jerome F. Strauss III
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  1. Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, New York, 11367-1597, USA

    Robert Bittman

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Martínez, F., Strauss, J.F. (1997). Regulation of Mitochondrial Cholesterol Metabolism. In: Bittman, R. (eds) Cholesterol. Subcellular Biochemistry, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5901-6_8

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  • DOI: https://doi.org/10.1007/978-1-4615-5901-6_8

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