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Has Nature Designed the Cholesterol Side Chain for Optimal Interaction with Phospholipids?

  • Chapter
Cholesterol

Part of the book series: Subcellular Biochemistry ((SCBI,volume 28))

Abstract

In view of the many roles played by cholesterol in membranes, it is not surprising that the interactions of cholesterol with phospholipids, and their consequences with respect to membrane structure and function, have been studied intensively for more than three decades. This chapter reviews recent studies on the importance of the isooctyl side chain of cholesterol on ordering of the acyl chains, as well as how variations in the alkyl side chain length affect the conformational order of fatty acyl chains of phospholipids in bilayer membranes and the molecular packing of phospholipids in monolayers. The discussion focuses on recent biophysical studies of liposomes and monolayers in which the alkyl chain length of the sterol and/or the acyl chain length of the phospholipid were varied. The results are interpreted according to the hydrophobic mismatch effect. Also reviewed in this chapter are some recent kinetic studies of intermembrane movement and intracellular transport of sterols having a side-chain structure different from that of cholesterol. For a recent review of other aspects of sterol-phospholipid interactions, including a more detailed discussion of the use of NMR spectroscopy to establish phase diagrams than are presented here, and an overview of differential interaction of cholesterol with subclasses of phospholipids, the reader is referred to Keough et al. (1996) and reference cited therein.

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  1. Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, New York, 11367-1597, USA

    Robert Bittman

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  1. Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, New York, 11367-1597, USA

    Robert Bittman

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Bittman, R. (1997). Has Nature Designed the Cholesterol Side Chain for Optimal Interaction with Phospholipids?. In: Bittman, R. (eds) Cholesterol. Subcellular Biochemistry, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5901-6_6

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  • DOI: https://doi.org/10.1007/978-1-4615-5901-6_6

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