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Cholesterol pp 89–116Cite as

Antifungal Sterol Biosynthesis Inhibitors

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 28))

Abstract

Herbal medicines and related drugs used to treat infective organisms were available in ancient cultures and detailed in the first pharmacopoeia reported in 1146 ad, titled “Antidotarium Niclai” (Grun, 1991). During the following millennium, there has been continued interest in drug discovery and application. However, only in the last fifty years have effective therapeutic agents for fungal disease been developed that exploit a fundamental difference between the biochemistry or physiology of the pathogens and their hosts. Sterol biosynthesis is one of the few areas of difference in primary metabolism between fungi and animals. Unlike animals that synthesize 24-desalkyl sterols, such as cholesterol (cholest-5-en-3β-ol), many pathogenic fungi synthesize 24-alkylsterols, such as ergosterol (24β-methyl cholesta-5,7,22-trien-3β-ol). The major difference in the two sterols stems structurally from the presence and nature of the 24-alkyl group.

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  1. Departments of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, 79409, USA

    De-an Guo, Anil T. Mangla, Wen Zhou, Monica Lopez, Zhonghua Jia, S. Derrek Nichols & W. David Nes

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  1. Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, New York, 11367-1597, USA

    Robert Bittman

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Guo, Da. et al. (1997). Antifungal Sterol Biosynthesis Inhibitors. In: Bittman, R. (eds) Cholesterol. Subcellular Biochemistry, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5901-6_4

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