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CREM

Transcriptional Pacemaker of the cAMP Response

  • Chapter
Cancer Genes

Part of the book series: Pezcoller Foundation Symposia ((PFSO,volume 7))

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Abstract

Transcription factors are elements able to integrate information from promoter sequences and signal transduction pathways to control the rate of gene expression. Several transcription factors have been characterised at both the structural and functional level. Their organization is intrinsically modular, in most cases including a DNA binding domain and an activation domain. It has been shown that these domains can be interchanged between different factors and still retain their functional properties. This modularity suggests that, during evolution, increasing complexity of gene expression may have resulted not only by duplication and divergence of existing genes, but also by a domain shuffling process to generate factors with novel properties1.

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Author information

Authors and Affiliations

  1. Institut de Génétique et de Biologie Moléculaire et Cellulaire, B. P. 163, 67404, Illkirch-Cédex C. U. de Strasbourg, France

    Janet S. Lee, Monica Lamas, Katherine Tamai, Emmanuel Zazopoulos, Lucia Penna, Nicholas S. Foulkes, François Nantel, Enzo Lalli & Paolo Sassone-Corsi

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  1. Janet S. Lee
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  2. Monica Lamas
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  3. Katherine Tamai
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  4. Emmanuel Zazopoulos
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  5. Lucia Penna
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  6. Nicholas S. Foulkes
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  7. François Nantel
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  8. Enzo Lalli
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  9. Paolo Sassone-Corsi
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Editor information

Editors and Affiliations

  1. Roswell Park Cancer Institute, Buffalo, New York, USA

    Enrico Mihich

  2. MIT Center for Cancer Research, Cambridge, Massachusetts, USA

    David Housman

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© 1996 Springer Science+Business Media New York

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Lee, J.S. et al. (1996). CREM. In: Mihich, E., Housman, D. (eds) Cancer Genes. Pezcoller Foundation Symposia, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5895-8_8

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  • DOI: https://doi.org/10.1007/978-1-4615-5895-8_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7704-7

  • Online ISBN: 978-1-4615-5895-8

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